DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment myo and Lefty1

DIOPT Version :9

Sequence 1:NP_726604.1 Gene:myo / 43811 FlyBaseID:FBgn0026199 Length:598 Species:Drosophila melanogaster
Sequence 2:NP_034224.1 Gene:Lefty1 / 13590 MGIID:107405 Length:368 Species:Mus musculus


Alignment Length:307 Identity:56/307 - (18%)
Similarity:93/307 - (30%) Gaps:128/307 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   336 EEIQPH-VRHNRKVDVFRFQIDSS----YSDLSYATLHLYLRGWDWISAHQPGLLEEIKKQPRKD 395
            :.:.|| .|....::..||:.|.|    ..|....::|  ..||......:.....:...:||:.
Mouse   134 KRLSPHSARARVTIEWLRFRDDGSNRTALIDSRLVSIH--ESGWKAFDVTEAVNFWQQLSRPRQP 196

  Fly   396 IVVTI--------------HRAIRVANTTSFNPKVKMFEFRHSIPSGLGQWV------AVDLKSL 440
            :::.:              |:.:|.|              ....|.|.||..      .:|||..
Mouse   197 LLLQVSVQREHLGPGTWSSHKLVRFA--------------AQGTPDGKGQGEPQLELHTLDLKDY 247

  Fly   441 LGNLGSNMTQEILIKGAETWMKSLVVTTDNTSKNPLTVHIEIGSQKKHRRKRSVYMDCTENDHDM 505
                           ||:.........|:.|                                  
Mouse   248 ---------------GAQGNCDPEAPVTEGT---------------------------------- 263

  Fly   506 RCCRYPLKVNFTSFGW--HFVVAPTSFDAYFCSGDCKVGYLEQYPHTHLAALTTSATPC-----C 563
            ||||..:.::.....|  ::::.|..|..|.|.|.|.     |.|.:     .||..|.     |
Mouse   264 RCCRQEMYLDLQGMKWAENWILEPPGFLTYECVGSCL-----QLPES-----LTSRWPFLGPRQC 318

  Fly   564 SPTKMSSLSLLYFDDNHNLVLSV------------IPNMSVEGCSCS 598
            ..::|:||.         :::||            :|||.|:.|||:
Mouse   319 VASEMTSLP---------MIVSVKEGGRTRPQVVSLPNMRVQTCSCA 356

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
myoNP_726604.1 TGF_beta 506..597 CDD:278448 27/109 (25%)
Lefty1NP_034224.1 TGFb_propeptide <106..211 CDD:279078 13/78 (17%)
TGF_beta 263..355 CDD:278448 28/144 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11848
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.100

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