Protein Alignment myo and Gdf2

DIOPT Version :10

• Sequence 1: NP_726604.1
• Gene: myo / 43811
• FlyBaseID: FBgn0026199
• Length: 598
• Species: Drosophila melanogaster
• Sequence 2: NP_062379.3
• Gene: Gdf2 / 12165
• MGIID: 1321394
• Length: 428
• Species: Mus musculus
• Alignment Length: 455
• Identity: 102/455 - (22%)
• Similarity: 163/455 - (35%)
• Gaps: 149/455 - (32%)

  Fly   207 IESIKMHILMRLNLKKLPNITKPISVPQNIIDNFYRDYNASSKTTVWNRMESIDESHLSINDTYG 271
            :|::|:..|..|||..:|:..|..:.|...:.:.|..|     ||
Mouse    58 LENMKVDFLRSLNLSGIPSQDKTRAEPPQYMIDLYNRY-----TT-------------------- 97

  Fly   272 DHIMTDFFDESSSSQMQGDDANTVNEFLIDLNKNQAKKSDIPINTNDEEYESILSHISSIYIFPE 336
                    |:||:..     :|.|..|.::...:.|...|.|...:             |.||..
Mouse    98 --------DKSSTPA-----SNIVRSFSVEDAISTAATEDFPFQKH-------------ILIFNI 136

  Fly   337 EIQPHVRHNRKVDVFRFQIDSSYSDLSYATLHLY------------LRG-------------WDW 376
            .|..|                  ..::.|.|.||            |.|             ||.
Mouse   137 SIPRH------------------EQITRAELRLYVSCQNDVDSTHGLEGSMVVYDVLEDSETWDQ 183

  Fly   377 ISAHQPGLL-EEIKKQPRKDIVVT--IHRAIRVANTTSFNPKVKMFEFRH---------SIPSG- 428
            .:..:..|: ::|:.:..:.:.|:  :.|.:|..:||:.| |:::....|         |:|.|
Mouse   184 ATGTKTFLVSQDIRDEGWETLEVSSAVKRWVRADSTTNKN-KLEVTVQSHRESCDTLDISVPPGS 247

  Fly   429 --LGQWVA-------------VDLKSLLGNLGSNMTQEILIKGAETWMKSLVVTTDNTSKNPLTV 478
              |..:|.             ::||.::|:....|    |:|.|:   .:..|..::..:..|..
Mouse   248 KNLPFFVVFSNDRSNGTKETRLELKEMIGHEQETM----LVKTAK---NAYQVAGESQEEEGLDG 305

  Fly   479 HIEIGSQKKHRRKRSVYMDCTENDHDMRCCRYPLKVNFTSFGW-HFVVAPTSFDAYFCSGDCKVG 542
            :..:|.... |||||.    ..:.|   |.:..|:|||...|| .:::||..:|||.|.|.|...
Mouse   306 YTAVGPLLA-RRKRST----GASSH---CQKTSLRVNFEDIGWDSWIIAPKEYDAYECKGGCFFP 362

  Fly   543 YLEQYPHT---------HLAALTTSATPCCSPTKMSSLSLLYFDDNHNLVLSV-IPNMSVEGCSC 597
            ..:....|         ||...|.....||.|||:|.:|:||.||.....|.. ...|||..|.|
Mouse   363 LADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISILYKDDMGVPTLKYHYEGMSVAECGC 427

  Fly   598  597
            Mouse   428  427

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
myo	NP_726604.1	TGF_beta_GDF8_like	506..597	CDD:381629	35/101 (35%)
Gdf2	NP_062379.3	TGFb_propeptide	69..215	CDD:480997	36/214 (17%)
		TGF_beta_BMP9	324..428	CDD:381670	37/107 (35%)
		Interaction with ENG. /evidence=ECO:0000250|UniProtKB:Q9UK05	401..415		6/13 (46%)