DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment myo and tgfb2

DIOPT Version :9

Sequence 1:	NP_726604.1	Gene:	myo / 43811	FlyBaseID:	FBgn0026199	Length:	598	Species:	Drosophila melanogaster
Sequence 2:	XP_002936067.1	Gene:	tgfb2 / 100489680	XenbaseID:	XB-GENE-480560	Length:	411	Species:	Xenopus tropicalis

Alignment Length:	484	Identity:	101/484 - (20%)
Similarity:	180/484 - (37%)	Gaps:	154/484 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 SVSLYRNTLINIESMLQRQLREKAKVDSIESIKMHILMRLNLKKLP-NITKPISVPQNIID--NF 240
            ::||...:.::::..::::         ||:|:..||.:|.|...| :..:|..|.|::|.  |.
Frog    18 ALSLSTCSTLDMDQFMRKR---------IEAIRGQILSKLKLNSPPEDYPEPGEVSQDVIAIYNS 73

  Fly   241 YRDY---NASSKTTVWNRMESIDESHLSINDTYGDHIMTDFFDESSSSQMQGDDANTVNEFLIDL 302
            .||.   .|:.:.....|..|.||.:                            |..|  :.||:
Frog    74 TRDLLQEKANERAASCERERSEDEYY----------------------------AKEV--YKIDM 108

  Fly   303 NKNQAKKSDIPINTNDEEYESILSHISSIYIFPEEIQPHVRHNRKVDVFRFQIDS---SYSDLSY 364
                     :|..|::.            .|.|....|:.|      :.||.:.|   :.|:|..
Frog   109 ---------LPYYTSEN------------VIPPSYTTPYFR------IVRFDVSSMEKNASNLVK 146

  Fly   365 ATLHLY--LRGWDWISAHQPGLLEEIKKQPRKDIVVTIHRAI--RVANTTSFNPKVKMFEFRHSI 425
            |...::  :.....:|..:..|.:.:|.   ||:.....|.|  :|..|.:
Frog   147 AEFRVFRLMNPKARVSEQRIELYQILKS---KDLASPTQRYIDSKVVKTRA-------------- 194

  Fly   426 PSGLGQWVAVDLKSLLG--------NLG--------------------SNMTQEILIKGA---ET 459
               .|:|::.|:...:.        |||                    .|.::|:..:.|   :.
Frog   195 ---EGEWLSFDVTEAINEWLHHKDRNLGFKISLHCPCCTFIPSNNYIIPNKSEELETRFAGIDDA 256

  Fly   460 WMKSLVVTTDNTSKNP-LTVHI--------EIGSQKKHRRKR----SVYMDCTENDHDMRCCRYP 511
            :|.:....|.:..|:. .|.|:        .:.||:..|||:    :.|  |..|..| .||..|
Frog   257 YMYAGDPKTKSRKKHTGRTPHLLLMLLPSYRLESQQSSRRKKRALDAAY--CFRNVQD-NCCLRP 318

  Fly   512 LKVNF-TSFGWHFVVAPTSFDAYFCSGDCKVGYLEQYPHTHLAAL------TTSATPCCSPTKMS 569
            |.::| ...||.::..|..::|.||:|.|...:.....|:.:.:|      ..||:|||....:.
Frog   319 LYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLD 383

  Fly   570 SLSLLYFDDNHNLVLSVIPNMSVEGCSCS 598
            ||::||:..|...: ..:.||.|:.|.||
Frog   384 SLTILYYIGNKPKI-EQLSNMIVKSCKCS 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
myo	NP_726604.1	TGF_beta	506..597	CDD:278448	29/97 (30%)
tgfb2	XP_002936067.1	TGFb_propeptide	21..228	CDD:366248	52/292 (18%)
tgfb2	XP_002936067.1	TGF_beta_TGFB2	314..410	CDD:381655	29/96 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11848
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010