DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11360 and MEX3A

DIOPT Version :9

Sequence 1:	NP_001259068.1	Gene:	CG11360 / 43810	FlyBaseID:	FBgn0039920	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	NP_001087194.1	Gene:	MEX3A / 92312	HGNCID:	33482	Length:	520	Species:	Homo sapiens

Alignment Length:	633	Identity:	239/633 - (37%)
Similarity:	292/633 - (46%)	Gaps:	194/633 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 LSDDPRTLQLAL-ELSLVGFND-------------NQNCYAQPA---QPLPMPLSARSDF--EIG 88
            |.:|.|.||||| :|.|:|..:             .....||||   ||.|.|..|....  ...
Human    31 LLEDERALQLALDQLCLLGLGEPPAPTAGEDGGGGGGGAPAQPAAPPQPAPPPPPAAPPAAPTAA 95

  Fly    89 TINSTLPIPSAPN-------CLLLPNAGAVSSEDRSKKSQNMTECVPVPSSEHVAEIVGRQGCKI 146
            ....|...|:||.       |.|...|     |.|.|.|.|.|||||||:|||||||||||||||
Human    96 PAAQTPQPPTAPKGASDAKLCALYKEA-----ELRLKGSSNTTECVPVPTSEHVAEIVGRQGCKI 155

  Fly   147 KALRAKTNTYIKTPVRGEEPVFVVTGRKEDVNKAKREILSAADHFSLIRASRKPVSDSQNNGMVG 211
            ||||||||||||||||||||||:||||:|||..|:|||:|||:|||:|||||
Human   156 KALRAKTNTYIKTPVRGEEPVFMVTGRREDVATARREIISAAEHFSMIRASR------------- 207

  Fly   212 STTSSGGGAVPRMSGPPCMPGQVTIQVRVPYRVVGLVVGPKGATIKHIQQETQTYIVTPSREKEP 276
               :..|.|   ....|.:||||||:||||||||||||||||||||.|||:|.|||:||||:::|
Human   208 ---NKSGAA---FGVAPALPGQVTIRVRVPYRVVGLVVGPKGATIKRIQQQTNTYIITPSRDRDP 266

  Fly   277 IFEVTGLPDNVDTARKQIEAHIALRTGS----------GSGSGD-AITMQSSDSVDTKEYASLPS 330
            :||:||.|.||:.||::||.|||:|||.          .:||.| ||..:.||:....:....|
Human   267 VFEITGAPGNVERAREEIETHIAVRTGKILEYNNENDFLAGSPDAAIDSRYSDAWRVHQPGCKP- 330

  Fly   331 LTQILNDDLNSEILSSIYKNSVPSTQEYANNSMKTVVNVSNSVKLVQGHHTGNCFQKSEFAEMEM 395
                         ||:..:||:....|         ..|.:..:..:....|..|....:.
Human   331 -------------LSTFRQNSLGCIGE---------CGVDSGFEAPRLGEQGGDFGYGGYL---- 369

  Fly   396 TANITAADILDKRLPGNEVSVPLAKANVANIVFRTTSSKTLSFCPP--------TSTSASFHSNC 452
                         .||..|    .|.:|...|..|:        ||        |.||..|
Human   370 -------------FPGYGV----GKQDVYYGVAETS--------PPLWAGQENATPTSVLF---- 405

  Fly   453 NANILTRSCSSASSTTSTKSTNNSANTPPEILNIWKSISDSIDVDEGIGDSPSIWNQPANIIPTA 517
                     |||||::|:.:   .|...|                                 |.|
Human   406 ---------SSASSSSSSSA---KARAGP---------------------------------PGA 425

  Fly   518 HCSPTISISPTDSLLGMGEHSANQQNLNHAKEPIMPNLP----QKIKGIQVQSNADNFLTHRECF 578
            |.||..|..|  .|.|:            .:.|  |..|    .|:.|..::|....    |:|.
Human   426 HRSPATSAGP--ELAGL------------PRRP--PGEPLQGFSKLGGGGLRSPGGG----RDCM 470

  Fly   579 VCNENTVTTALVPCGHNMFCMECANHICLSMDAVCPVCNSIVYHAMRI 626
            ||.|:.||.||||||||:||||||..||...|..||||:.....|:||
Human   471 VCFESEVTAALVPCGHNLFCMECAVRICERTDPECPVCHITATQAIRI 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11360	NP_001259068.1	KH-I	124..185	CDD:238053	54/60 (90%)
		KH	233..298	CDD:197652	47/64 (73%)
		zf-C3HC4_3	575..620	CDD:290631	28/44 (64%)
MEX3A	NP_001087194.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	49..111		14/61 (23%)
		KH-I_MEX3_rpt1	132..204	CDD:411851	61/71 (86%)
		KH-I_MEX3_rpt2	221..292	CDD:411852	52/70 (74%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	412..461		17/100 (17%)
		RING-HC_MEX3	469..509	CDD:319432	26/39 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146513
Domainoid	1	1.000	109	1.000	Domainoid score	I6336
eggNOG	1	0.900	-	-		E1_KOG2113
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D351875at33208
OrthoFinder	1	1.000	-	-		FOG0001319
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23285
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5311
SonicParanoid	1	1.000	-	-		X819
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.840