DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11360 and Mex3c

DIOPT Version :9

Sequence 1:	NP_001259068.1	Gene:	CG11360 / 43810	FlyBaseID:	FBgn0039920	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	NP_001100847.1	Gene:	Mex3c / 307271	RGDID:	1309023	Length:	464	Species:	Rattus norvegicus

Alignment Length:	569	Identity:	219/569 - (38%)
Similarity:	277/569 - (48%)	Gaps:	175/569 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 AGAVSSEDRS---KKSQNMTECVPVPSSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPVFV 169
            |.|::.|..:   :||.|.|||||||||||||||||||||||||||||||||||||||||||:||
  Rat    19 AAALNGEQAALLRRKSVNTTECVPVPSSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPIFV 83

  Fly   170 VTGRKEDVNKAKREILSAADHFSLIRASRKPVSDSQNNGMVGSTTSSGGGAVPRMSGPPCMPGQV 234
            ||||||||..|||||||||:|||:|||||                :..|.|:..:|..|.:|||.
  Rat    84 VTGRKEDVAMAKREILSAAEHFSMIRASR----------------NKNGPALGGLSCSPNLPGQT 132

  Fly   235 TIQVRVPYRVVGLVVGPKGATIKHIQQETQTYIVTPSREKEPIFEVTGLPDNVDTARKQIEAHIA 299
            |:|||||||||||||||||||||.|||:|.||||||||:|||:|||||:|:|||.||::||.|||
  Rat   133 TVQVRVPYRVVGLVVGPKGATIKRIQQQTHTYIVTPSRDKEPVFEVTGMPENVDRAREEIEMHIA 197

  Fly   300 LRTGSGSGSGDAITMQSSDSVDTKEYASLPSLTQILNDDLNSEILSSIYKNSVPSTQEYANNSMK 364
            :|||:                    |.           :||.|                  |..
  Rat   198 MRTGN--------------------YI-----------ELNEE------------------NDF- 212

  Fly   365 TVVNVSNSVKLVQGHHTGN--CFQKSEFAEMEMTANITAADILDKRLPGNEVSVPLAKANVANIV 427
                          |:.|.  .|:........:::|                .||.::|.:.: .
  Rat   213 --------------HYNGTDVSFEGGTLGSAWLSSN----------------PVPPSRARMMS-N 246

  Fly   428 FRTTSSKTLSFCPPTSTSASFHSNCNANILTRSCSSASSTTSTKSTNN--SANTPPEILNIWKSI 490
            :|..||.:|.   ..||.:.|.||..|:.         |.||..||.|  ..:|.|.:      .
  Rat   247 YRNDSSSSLG---SGSTDSYFGSNRLADF---------SPTSPFSTGNFWFGDTLPSV------G 293

  Fly   491 SDSIDVDEGIGDSPSIWNQPANIIPTAHCSPTISISPTDSLLGMG-EHSANQQNLNHAKEP---- 550
            |:.:.||....||          :||:..:......|.:.|.|.| :.|.|.:......:|
  Rat   294 SEDLAVDSPAFDS----------LPTSAQTIWTPFEPVNPLSGFGSDPSGNMKTQRRGSQPSTPR 348

  Fly   551 IMPNLPQKIK------------------GIQVQ----SNADNFLT----------------HREC 577
            :.|..|:.|:                  |:.:.    ||..|..:                ..:|
  Rat   349 LSPTFPESIEHPLARRVRSDPPSTGNHVGLPIYIPAFSNGTNSYSSSNGGSTSSSPPESRRKHDC 413

  Fly   578 FVCNENTVTTALVPCGHNMFCMECANHICLSMDAVCPVCNSIVYHAMRI 626
            .:|.||.|..||||||||:|||||||.||......||||.:.|..|::|
  Rat   414 VICFENEVIAALVPCGHNLFCMECANKICEKRTPSCPVCQTAVTQAIQI 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11360	NP_001259068.1	KH-I	124..185	CDD:238053	57/60 (95%)
		KH	233..298	CDD:197652	51/64 (80%)
		zf-C3HC4_3	575..620	CDD:290631	26/44 (59%)
Mex3c	NP_001100847.1	KH-I	38..99	CDD:238053	57/60 (95%)
		KH	131..196	CDD:197652	51/64 (80%)
		zf-C3HC4_3	413..458	CDD:290631	27/44 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340316
Domainoid	1	1.000	120	1.000	Domainoid score	I5616
eggNOG	1	0.900	-	-		E1_KOG2113
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	347	1.000	Inparanoid score	I2236
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D351875at33208
OrthoFinder	1	1.000	-	-		FOG0001319
OrthoInspector	1	1.000	-	-		otm45636
orthoMCL	1	0.900	-	-		OOG6_106586
Panther	1	1.100	-	-	O	PTHR23285
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X819
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.800