DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11360 and mex-3

DIOPT Version :9

Sequence 1:	NP_001259068.1	Gene:	CG11360 / 43810	FlyBaseID:	FBgn0039920	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	NP_490681.2	Gene:	mex-3 / 171607	WormBaseID:	WBGene00003229	Length:	443	Species:	Caenorhabditis elegans

Alignment Length:	445	Identity:	170/445 - (38%)
Similarity:	217/445 - (48%)	Gaps:	110/445 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 QNMTECVPVPSSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPVFVVTGRKEDVNKAKREIL 185
            ||:||.|.||:|||||||||||||||||||||||||||||||||:|:||||||.||||:|||||.
Worm    76 QNVTESVEVPTSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEDPIFVVTGRLEDVNEAKREID 140

  Fly   186 SAADHFSLIRASRKPVSDSQNNGMVGSTTSSGGGAVPRMSGPPCMPGQVTIQVRVPYRVVGLVVG 250
            .||:||:.|||||:              .:.|..|          |||:|..||||.||||||||
Worm   141 CAAEHFTQIRASRR--------------HTQGAHA----------PGQITSYVRVPLRVVGLVVG 181

  Fly   251 PKGATIKHIQQETQTYIVTPSREKEPIFEVTGLPDNVDTARKQIEAHIALRTGSGSGSGDAITMQ 315
            |||||||.|||:|.|||:|||||:||:|||||||.||:.|||:||.||..|||:         :.
Worm   182 PKGATIKRIQQDTHTYIITPSREREPVFEVTGLPHNVEAARKEIETHIFQRTGN---------LP 237

  Fly   316 SSDSVDTKEYASLPSLTQILNDDLNSEILSSIYKNSVPSTQEYANNSMKTVVNVSNSVKLVQGHH 380
            .:|:....:.|.:..:.|                     .|:.|...|:.....|...:...|:
Worm   238 ETDNDFAGQLAGVSLMVQ---------------------KQQQAQQQMQEAQQQSMFYRRAFGN- 280

  Fly   381 TGNCFQKSEFAEMEMTANITAADILDKRLP-GNEVSVPLAKANVANIVFRTTSSKTLSFCPP--T 442
                  .:.|.:.||:::           | |.|.|:.|      :.:.|:..|...|..|.  :
Worm   281 ------SNPFNQKEMSSS-----------PFGMESSLGL------DALLRSFPSMRSSLTPESLS 322

  Fly   443 STSASFHSNCNANILTRSCSSASSTTSTKSTNNSANTPPE---------ILNIWKS--------- 489
            .|..|...:....   :|......|.....||||.|...|         .|:.|.|
Worm   323 GTGLSSRPSLGGG---QSAKQDLPTYDYWGTNNSLNDIMENEILSRKYDALSAWSSMGLEKREES 384

  Fly   490 -----ISDSIDVDEGIGDSPSIWN-QPANIIPTAHCSPTISISPTDSLLGMGEHS 538
                 :|.......|.|...:||: ...|:.|.:..|  .|.|||.|.....:|:
Worm   385 PTNGLMSSLKGTSAGFGLLSTIWSGGNMNLSPGSLAS--ASASPTSSTCDHNDHT 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11360	NP_001259068.1	KH-I	124..185	CDD:238053	53/60 (88%)
		KH	233..298	CDD:197652	49/64 (77%)
		zf-C3HC4_3	575..620	CDD:290631
mex-3	NP_490681.2	KH-I	79..139	CDD:238053	52/59 (88%)
mex-3	NP_490681.2	KH	164..229	CDD:197652	49/64 (77%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166551
Domainoid	1	1.000	110	1.000	Domainoid score	I3972
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4937
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001319
OrthoInspector	1	1.000	-	-		oto19844
orthoMCL	1	0.900	-	-		OOG6_106586
Panther	1	1.100	-	-	LDO	PTHR23285
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5311
SonicParanoid	1	1.000	-	-		X819
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.820