Protein Alignment Slip1 and PDZRN4

DIOPT Version :10

• Sequence 1: NP_651933.1
• Gene: Slip1 / 43809
• FlyBaseID: FBgn0024728
• Length: 767
• Species: Drosophila melanogaster
• Sequence 2: NP_001158067.1
• Gene: PDZRN4 / 29951
• HGNCID: 30552
• Length: 1036
• Species: Homo sapiens
• Alignment Length: 819
• Identity: 194/819 - (23%)
• Similarity: 339/819 - (41%)
• Gaps: 206/819 - (25%)

  Fly    12 VLKINGYDISHLSRYEAVQKFLQSKETLVVEIRRQKHNALDLELKHGSNAKISKVDNPGELSVLT 76
            ::::||.|:|..:..|||:.|..:||.:||::.|:                 :.:..|.     .
Human   279 IMEVNGKDLSKATHEEAVEAFRNAKEPIVVQVLRR-----------------TPLSRPA-----Y 321

  Fly    77 DKSAEGTITAASASQQINCPSSTSLKEIETKTPVVLTLRARSHEDRLGSLQAASKETQTQSVVGT 141
            ..::|..:..||....|......:|.::...||.|..:......|...||.....|
Human   322 GMASEVQLMNASTQTDITFEHIMALAKLRPPTPPVPDICPFLLSDSCHSLHPMEHE--------- 377

  Fly   142 DVLKDNDLVNTI------TDNFIEHEHHLFEQCLEPEIDIEEVTLVKGVEQSSSNQIGLIVTSSG 200
             ..:||:.::::      |::|                :.|||.|.:   .||..::||.|.
Human   378 -FYEDNEYISSLPADADRTEDF----------------EYEEVELCR---VSSQEKLGLTVC--- 419

  Fly   201 IQQSSTDTNKGDILGNVLEHSEDVFISGVQPESIAYRDGRLRQGDQILRINGLDVKNQEELETQI 265
               ..||.          |....:::|.|.|.|||.:|||:|:||:||:|||.||:|:||....:
Human   420 ---YRTDD----------EEDTGIYVSEVDPNSIAAKDGRIREGDRILQINGEDVQNREEAVALL 471

  Fly   266 ARSSTS-VTLLVSRILYPEDDDDEDIHFEYANTFLPDDYTNVVDKLDKVLLTHVKSLEELSNKSA 329
            :..... :.|||:|   ||...||.        :|.|:....:::|      :::.|||..|::.
Human   472 SNDECKRIVLLVAR---PEIQLDEG--------WLEDERNEFLEEL------NLEMLEEEHNEAM 519

  Fly   330 MQSDECYHIPEK------------NSSDSNVKISSLAKNIIEQSTKSCSKIKLR-----PNANLD 377
            ..:......|:|            :||:::.|.|.:.:.  ::|.::....:..     ||:. .
Human   520 QPTANEVEQPKKQEEEEGTTDTATSSSNNHEKDSGVGRT--DESLRNDESSEQENAAEDPNST-S 581

  Fly   378 YKKKFNLPLSQEEV-HLQYEYDESEHIYETIPEDSESEP------------VYC-----SPYQRS 424
            .|.|.:|..||:.: .::.:|:||....|.|..|....|            :.|     ..|...
Human   582 LKSKRDLGQSQDTLGSVELQYNESLVSGEYIDSDCIGNPDEDCERFRQLLELKCKIRNHGEYDLY 646

  Fly   425 NDKTSIGCSSPIASRPAESLE------RTMQQQTQRVAQWLGLKPQYQKTRQTLVGRPPPLKLVQ 483
            ...::|.|:..........|:      |.::.:.|.:.|...|:                 |:..
Human   647 YSSSTIECNQGEQEGVEHELQLLNEELRNIELECQNIMQAHRLQ-----------------KVTD 694

  Fly   484 QPTCSRVFTLRS---TLTNTSASSSSGVAYSSYGQNNVVTGNAAAPGEEVDNSSSAYNTGDSNNS 545
            |  ...::||..   ...|||.....|..      ::::    ..|.:...:|||||||.:|..|
Human   695 Q--YGDIWTLHDGGFRNYNTSIDMQRGKL------DDIM----EHPEKSDKDSSSAYNTAESCRS 747

  Fly   546 ASPHQNTTNPDEAIATGRKLDSTVIDSPNDHLDATGVSTMLLLPFGKSGRIGLCSSNLPTAYVSE 610
             :|.....:||.::.  |.::.|...:....:.||..|:      |:|.:    .|....|..:|
Human   748 -TPLTVDRSPDSSLP--RVINLTNKKNLRSTMAATQSSS------GQSSK----ESTSTKAKTTE 799

  Fly   611 RYTNVGSENEIHPLKSDIEILRVKPTDDSYS-HCPQFNAPNLSSY----------HFVSSQEVAN 664
            :..:..|:.::      :|..::...:.:.| |.|..:..:.|||          |:.|..::..
Human   800 QGCSAESKEKV------LEGSKLPDQEKAVSEHIPYLSPYHSSSYRYANIPAHARHYQSYMQLIQ 858

  Fly   665 RCHISTSLQKNATLLN----GESAEEIPMVWKVKRRPDGTRYIVKRPVRNRPQVALRKNMRYNEV 725
            :.......|...:|::    .:...|..|.||||.|.||||||.|||||:|  :...:.::..|.
Human   859 QKSAVEYAQSQLSLVSMCKESQKCSEPKMEWKVKIRSDGTRYITKRPVRDR--ILKERALKIKEE 921

  Fly   726 ---TTTEDDTISEVKIGRYWTKEERKRHIERAREKRHHQ 761
               .||:|||:||:|:||||:|||||:|:.||:|:|..:
Human   922 RSGMTTDDDTMSEMKMGRYWSKEERKQHLVRAKEQRRRR 960

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Slip1	NP_651933.1	PDZ_canonical	<11..45	CDD:483948	12/32 (38%)
		PDZ_canonical	173..279	CDD:483948	37/106 (35%)
PDZRN4	NP_001158067.1	RING-HC_LNX4	12..64	CDD:438379
		PDZ1-PDZRN4-like	221..312	CDD:467199	12/32 (38%)
		PDZ2-PDZRN4-like	398..486	CDD:467200	39/125 (31%)