DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gw and tnrc6bb.1

DIOPT Version :9

Sequence 1:	NP_726596.1	Gene:	gw / 43808	FlyBaseID:	FBgn0051992	Length:	1384	Species:	Drosophila melanogaster
Sequence 2:	XP_005165521.1	Gene:	tnrc6bb.1 / 793145	ZFINID:	ZDB-GENE-070705-475	Length:	1472	Species:	Danio rerio

Alignment Length:	1376	Identity:	314/1376 - (22%)
Similarity:	454/1376 - (32%)	Gaps:	450/1376 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GWGCQHVNQDTNWEVPSSPEPANKDAPGPPMWKPSIN--NGTDLWE-----SNLRNGGQPAAQQV 67
            |||...:.|:..|:..:.        .|...|...:|  ...:.|:     ||.:...|......
Zfish   431 GWGKTQIKQNVAWDFEAD--------VGNVGWDAEVNTERSKEGWQEAGDLSNSKMQKQEVGHMG 487

  Fly    68 PKPSWGHTPSSNLG-----GTWGEDDDGADSSSVWTGGAVSNAGSGAAVGVNQAGVNVGPGGVVS 127
            ....|......::|     |.||||.:||.          ...|:|
Zfish   488 RAQGWTERGEMSIGTGHKAGGWGEDQEGAS----------RREGTG------------------- 523

  Fly   128 SGGPQWGQGVVGVGLGSTGGNGSSNITGSSGVATGSSGNSSNAGNGWGDPREIRPLGVGGSMDIR 192
                 |.||         ||...:.:..:.|... ..|.:.|.|. ||.|.:..|.  .|..|.:
Zfish   524 -----WSQG---------GGKEWTPVPEAGGWKE-EKGTNQNEGL-WGSPEDSGPR--SGGWDCK 570

  Fly   193 NVEHRGGNGSGATSSDPRDIRMIDPRDPIRGDPRGISGRLNGTSEMWGHHPQ---MSHNQLQGIN 254
            .  |:|.......|..|.....:..::                     ..||   .:..|:.|..
Zfish   571 T--HQGWGEKLLPSQIPNKQAALKTQN---------------------QQPQQQSQTQQQMPGYP 612

  Fly   255 KMVGQSVATASTSVGTSGSGIGPGGPGPSTVSGNIPTQWGPAQPVSVGVSGPKDMSKQISGWEEP 319
            |:|.....|......:.||| ...||.|...|...|                       |||:||
Zfish   613 KVVQDRGRTGENDEQSKGSG-WSCGPIPQIASAGEP-----------------------SGWDEP 653

  Fly   320 SPPPQRRSIPNYDDGTSLWGQQTRVPAASGHWKDMTDSIGRSSHLMRGQSQTGGIGIAGV--GNS 382
            ||....|.: :.|||||.||..:|..:.:.:..|...|        :.|.|:.| ..||.  .||
Zfish   654 SPQSISRKM-DIDDGTSAWGDPSRYSSKNVNLWDKNSS--------QPQQQSSG-RPAGTPSKNS 708

  Fly   383 NVPVGANPSNPISSVV--GPQARIPSVGGVQHKP-DGGAMWVHSGNVGGRNNVAAVTTWGDD-TH 443
            ...:....|.|..|.:  ||...:        || ||.:.|..|...|...       ||:. :|
Zfish   709 GPAIWTRSSGPSDSSMESGPAPWV--------KPFDGSSGWGESSEPGKGG-------WGNSHSH 758

  Fly   444 SVNVGAPSSGSVSSNNWVDDKSNSTLAQNSWSDPAPVGVSWGNK--QSKPPSNSASSGWSTAAGV 506
            ....|:.|    ....|.|:.|||: ..:||.:..  |..||.:  ||...|:.:|.||
Zfish   759 PNKTGSKS----MQEGWGDEGSNSS-RHSSWEEED--GGVWGGRGSQSNMSSSYSSGGW------ 810

  Fly   507 VDGVDLGSEWNTHGGIIGKSQQQQKLAGLNVGMVNVINAEIIKQSKQYRILVENGFKKEDVERAL 571
                             |:||..::|:..:....|..::.:...|:|:
Zfish   811 -----------------GQSQGSRRLSSKSPLKGNSGDSWVSPVSRQF----------------- 841

  Fly   572 VIANMNIEEAADMLRANSSLSMDGWRRHD-------------ESLGSYADHNSSTSSGGFAGRYP 623
              :||.:.:      .:||:..|  .|||             .:.|::....:..:..|.:|.|
Zfish   842 --SNMGVTD------DDSSMGHD--NRHDRRGMSDGEMRRGGRTGGAFRSQTAKETGCGESGPY- 895

  Fly   624 VNSGQPSMSFPHNNLMNNMGGTAVTGGNNNTNMTALQVQKYLNQGQHGVAVGPQAVGNSSAVSVG 688
                           ::.:||..:.||....           .:|.|...|.|
Zfish   896 ---------------LDKVGGHGMFGGGIPP-----------MRGMHQAGVHP------------ 922

  Fly   689 FGQNTSNAAVAGAASVNIAANTNNQPSGQQIRMLGQQIQLAIHSGFISSQI---LTQPLTQTTLN 750
                                 .|..|.          |:..:...|:..|:   :.:|:...:..
Zfish   923 ---------------------LNPSPG----------IRAQVPHQFLPPQVPGPMLKPMAPPSGG 956

  Fly   751 LLNQLLSNIKHLQAAQQSLTRGGNVNPMAVNVAISKYKQQIQNLQNQINAQQAVYVKQQNMQPTS 815
            :....||        .|.:...|.:||     .:.:::...|.|..|...||..::.|:...|..
Zfish   957 MFPPQLS--------PQHIAMLGGINP-----HMQQFQLACQLLLQQQQQQQQQFLNQRKFSPPL 1008

  Fly   816 QQQ-------------QPQQQQL-------------------PSVHLSNSGNDYLRGHDAINNLQ 848
            :||             |.||||.                   |..||.:.|.:..:..:|..:..
Zfish  1009 RQQHDPQQLARIMAILQQQQQQQGVVGPKLSPSPLGAHIPKHPDTHLHHLGLNTHKPPEAAVHAA 1073

  Fly   849 SNFSELNINKPSGYQGASNQQSRLNQWKLPVLDKEINSDSTEFSRAPGATKQNLTANTSNINSLG 913
            ...|||:...|:.|.||.         |||        |.:.||
Zfish  1074 IGVSELHNKAPAAYTGAV---------KLP--------DGSSFS--------------------- 1100

  Fly   914 LQNDSTWSTGRSIGDGWPDPSSDNENKDWSVAQPTSAATAYTDLVQEFEPGKPWKGSQIKSIEDD 978
             |.|       .:|.||          ..|.|....|..|......||:||.||||......:.|
Zfish  1101 -QYD-------VLGSGW----------HRSAAGKVDAPPANPSWPPEFQPGVPWKGLPSHESDPD 1147

  Fly   979 PSITPGSVARSPLSINSTPKDADIFANTGKNS-PTDLP-----PLSLSSSTWSFNPNQNYP--SH 1035
            |.:||..:..|  |:.|..:...:..|||.|| .|.:|     |.|.|....:.:....|.  ..
Zfish  1148 PYMTPAGMLGS--SLLSDTEHHLLQDNTGSNSVNTCMPSPGAWPYSASDPPLTAHGTAKYTELKS 1210

  Fly  1036 SWSDNSQQCTATSELWTSPLNKSSSRGPPPGLTANSNKSANSNASTPTTITGGANGWLQPRSGGV 1100
            ||   ..:....|:.|.:..|.|....|||||::.................|||:|...|
Zfish  1211 SW---PPEPIGHSKSWRTNRNASQMPRPPPGLSSQKQPWVEEGPRMARAWGGGASGTDTP----- 1267

  Fly  1101 QTTNTNWTGGNTTWGSSWLLLKNLTAQIDGPTLRTLCMQHGPLVSFHPYLNQGIALCKYTTREEA 1165
              ..:.|:.|..:.|.|||||:|||.||||.||||:|:|||||::||..|.||.||.:|.:..||
Zfish  1268 --FKSEWSDGGASAGKSWLLLRNLTPQIDGSTLRTICLQHGPLLTFHLGLTQGSALIRYCSPHEA 1330

  Fly  1166 NKAQMALNNCVLANTTIFAESPSENEVQSIMQH--------LPQ-TPSSTSSSGTSGGNV----G 1217
            .|||.||:.|||.||||.||..||.:|.....|        .|: :|.|.|..|.....|    .
Zfish  1331 AKAQSALHMCVLGNTTILAEFMSEEDVIRYFTHSQAAGVAGSPEVSPGSDSREGERAPGVPDGDA 1395

  Fly  1218 GVGTSANNANSGSAACLSG--------NNSGNGNGSA--SGAGSGNNGNSSCN------------ 1260
            .||....:...||...:.|        ||:|.|.|..  .|...|.:|:|...
Zfish  1396 PVGWQGLDGAPGSTVEVPGLAILSQWSNNAGEGAGKGVWGGVAPGYHGSSLWGAPQLEDGTAGLL 1460

  Fly  1261 -NSAAGGGSSS 1270
             .:..|||:.|
Zfish  1461 PGNLLGGGTDS 1471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gw	NP_726596.1	Ago_hook	388..520	CDD:287408	33/137 (24%)
		UBA_GAWKY	551..585	CDD:270470	4/33 (12%)
		M_domain	613..848	CDD:289690	42/269 (16%)
		TNRC6-PABC_bdg	844..1068	CDD:293214	58/231 (25%)
		RRM_GW182_like	1116..1185	CDD:240881	44/68 (65%)
tnrc6bb.1	XP_005165521.1	Ago_hook	718..>793	CDD:287408	24/96 (25%)
		TNRC6-PABC_bdg	<1084..1280	CDD:293214	63/263 (24%)
		RRM_SF	1283..1363	CDD:302621	48/79 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	292	1.000	Inparanoid score	I2766
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24990
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13020
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X744
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	5	5.110