Protein Alignment gw and tnrc6bb.1

DIOPT Version :10

• Sequence 1: NP_726596.1
• Gene: gw / 43808
• FlyBaseID: FBgn0051992
• Length: 1384
• Species: Drosophila melanogaster
• Sequence 2: NP_001429597.1
• Gene: tnrc6bb.1 / 793145
• ZFINID: ZDB-GENE-070705-475
• Length: 1471
• Species: Danio rerio
• Alignment Length: 1373
• Identity: 314/1373 - (22%)
• Similarity: 457/1373 - (33%)
• Gaps: 445/1373 - (32%)

  Fly    10 GWGCQHVNQDTNWEVPSSPEPANKDAPGPPMWKPSIN--NGTDLWE-----SNLRNGGQPAAQQV 67
            |||...:.|:..|:..:.        .|...|...:|  ...:.|:     ||.:...|......
Zfish   431 GWGKTQIKQNVAWDFEAD--------VGNVGWDAEVNTERSKEGWQEAGDLSNSKMQKQEVGHMG 487

  Fly    68 PKPSWGHTPSSNLG-----GTWGEDDDGADSSSVWTGGAVSNAGSGAAVGVNQAGVNVGPGGVVS 127
            ....|......|:|     |.||||.:||.          ...|:|
Zfish   488 RAQGWTERGEMNVGIGHKAGGWGEDQEGAS----------RREGTG------------------- 523

  Fly   128 SGGPQWGQGVVGVGLGSTGGNGSSNITGSSGVATGSSGNSSNAGNGWGDPREIRPLGVGGSMDIR 192
                 |.||         ||...:.:..:.|... ..|.:.|.|. ||.|.:..|.  .|..|.:
Zfish   524 -----WSQG---------GGKEWTPVPEAGGWKE-EKGTNQNEGL-WGSPEDSGPR--SGGWDCK 570

  Fly   193 NVEHRGGNGSGATSSDPRDIRMIDPRDPIRGDPRGISGRLNGTSEMWGHHPQ---MSHNQLQGIN 254
            .  |:|.......|..|.....:..::                     ..||   .:..|:.|..
Zfish   571 T--HQGWGEKLLPSQIPNKQAALKTQN---------------------QQPQQQSQTQQQMPGYP 612

  Fly   255 KMVGQSVATASTSVGTSGSGIGPGGPGPSTVSGNIPTQWGPAQPVSVGVSGPKDMSKQISGWEEP 319
            |:|.....|......:.||| ...||.|...|...|                       |||:||
Zfish   613 KVVQDRGRTGENDEQSKGSG-WSCGPIPQIASAGEP-----------------------SGWDEP 653

  Fly   320 SPPPQRRSIPNYDDGTSLWGQQTRVPAASGHWKDMTDSIGRSSHLMRGQSQTGGIGIAGVGNSNV 384
            ||....|.: :.|||||.||..:|..:.:.:..|...|        :.|.|:.|          .
Zfish   654 SPQSISRKM-DIDDGTSAWGDPSRYSSKNVNLWDKNSS--------QPQQQSSG----------R 699

  Fly   385 PVGANPSNPISSVVGPQARIPSVGGVQHKPDGGAMWVHS--GNVG-GRNNVAAVTTWGDD-THSV 445
            |.| .||......:..::..||...::   .|.|.||.|  |:.| |.::......||:. :|..
Zfish   700 PAG-TPSKNSGPAIWTRSSGPSDSSME---SGPAPWVKSFDGSSGWGESSEPGKGGWGNSHSHPN 760

  Fly   446 NVGAPSSGSVSSNNWVDDKSNSTLAQNSWSDPAPVGVSWGNK--QSKPPSNSASSGWSTAAGVVD 508
            ..|:.|    ....|.|:.|||: ..:||.|..  |..||.:  ||...|:.:|.||
Zfish   761 KTGSKS----MQEGWGDEGSNSS-RHSSWEDED--GGVWGGRGSQSNMSSSYSSGGW-------- 810

  Fly   509 GVDLGSEWNTHGGIIGKSQQQQKLAGLNVGMVNVINAEIIKQSKQYRILVENGFKKEDVERALVI 573
                           |:||..::|:..:....|..::.:...|:|:
Zfish   811 ---------------GQSQGSRRLSSKSPLKGNSGDSWVSPVSRQF------------------- 841

  Fly   574 ANMNIEEAADMLRANSSLSMDGWRRHD-------------ESLGSYADHNSSTSSGGFAGRYPVN 625
            :||.:.:      .:||:..|  .|||             .:.|::....:..:..|.:|.|
Zfish   842 SNMGVTD------DDSSMGHD--NRHDRRGMSDGEMRRGGRTGGAFRSQTAKETGCGESGPY--- 895

  Fly   626 SGQPSMSFPHNNLMNNMGGTAVTGGNNNTNMTALQVQKYLNQGQHGVAVGPQAVGNSSAVSVGFG 690
                         ::.:||..:.||....           .:|.|...|.|
Zfish   896 -------------LDKVGGHGMFGGGIPP-----------MRGMHQAGVHP-------------- 922

  Fly   691 QNTSNAAVAGAASVNIAANTNNQPSGQQIRMLGQQIQLAIHSGFISSQI---LTQPLTQTTLNLL 752
                               .|..|.          |:..:...|:..|:   :.:|:...:..:.
Zfish   923 -------------------LNPSPG----------IRAQVPHQFLPPQVPGPMLKPMAPPSGGMF 958

  Fly   753 NQLLSNIKHLQAAQQSLTRGGNVNPMAVNVAISKYKQQIQNLQNQINAQQAVYVKQQNMQPTSQQ 817
            ...||        .|.:...|.:||     .:.:::...|.|..|...||..::.|:...|..:|
Zfish   959 PPQLS--------PQHIAMLGGINP-----HMQQFQLACQLLLQQQQQQQQQFLNQRKFSPPLRQ 1010

  Fly   818 Q-------------QPQQQQ------------------LPSVHLSNSGNDYLRGHDAINNLQSNF 851
            |             |.||||                  .|..||.:.|.:..:..:|..:.....
Zfish  1011 QHDPQQLARIMAILQQQQQQGVVGPKLSPSPLGAHIPKHPDTHLHHLGLNTHKPPEAAVHAAIGG 1075

  Fly   852 SELNINKPSGYQGASNQQSRLNQWKLPVLDKEINSDSTEFSRAPGATKQNLTANTSNINSLGLQN 916
            |||:...|:.|.||.         |||        |.:.||                      |.
Zfish  1076 SELHNKAPAAYTGAV---------KLP--------DGSSFS----------------------QY 1101

  Fly   917 DSTWSTGRSIGDGWPDPSSDNENKDWSVAQPTSAATAYTDLVQEFEPGKPWKGSQIKSIEDDPSI 981
            |       .:|.||          ..|.|....|:.|......||:||.||||......:.||.:
Zfish  1102 D-------VLGSGW----------HRSAAGKVDASPANPSWPPEFQPGVPWKGLPSHESDPDPYM 1149

  Fly   982 TPGSVARSPLSINSTPKDADIFANTGKNS-PTDLP-----PLSLSSSTWSFNPNQNYP--SHSWS 1038
            ||..:..|  |:.|..:...:..|||.|| .|.:|     |.|.|....:.:....|.  ..||
Zfish  1150 TPAGMLGS--SLLSDTEHHLLQDNTGSNSVNTCMPSPGAWPYSASDPPLTAHGTAKYTELKSSW- 1211

  Fly  1039 DNSQQCTATSELWTSPLNKSSSRGPPPGLTANSNKSANSNASTPTTITGGANGWLQPRSGGVQTT 1103
              ..:....|:.|.:..|.|....|||||::.................|||:|...|       .
Zfish  1212 --PPEPIGHSKSWRTNRNASQLPRPPPGLSSQKQPWVEEGPRMARAWGGGASGTDTP-------F 1267

  Fly  1104 NTNWTGGNTTWGSSWLLLKNLTAQIDGPTLRTLCMQHGPLVSFHPYLNQGIALCKYTTREEANKA 1168
            .:.|:.|..:.|.|||||:|||.||||.||||:|:|||||::||..|.||.||.:|.:..||.||
Zfish  1268 KSEWSDGGASAGKSWLLLRNLTPQIDGSTLRTICLQHGPLLTFHLGLTQGSALIRYCSPHEAAKA 1332

  Fly  1169 QMALNNCVLANTTIFAESPSENEVQSIMQH--------LPQ-TPSSTSSSGTSGGNV----GGVG 1220
            |.||:.|||.||||.||..||.:|.....|        .|: :|.|.|..|.....|    ..||
Zfish  1333 QSALHMCVLGNTTILAEFMSEEDVIRYFTHSQAAGVAGSPEVSPGSDSREGERAPGVPDGDAPVG 1397

  Fly  1221 TSANNANSGSAACLSG--------NNSGNGNGSA--SGAGSGNNGNSSCN-------------NS 1262
            ....:...||...:.|        ||:|.|.|..  .|...|.:|:|...             .:
Zfish  1398 WQGLDGAPGSTVEVPGLAILSQWSNNAGEGAGKGVWGGVAPGYHGSSLWGAPQLEDGTAGLLPGN 1462

  Fly  1263 AAGGGSSS 1270
            ..|||:.|
Zfish  1463 LLGGGTDS 1470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gw	NP_726596.1	Ago_hook	388..525	CDD:463088	34/142 (24%)
		UBA_GAWKY	551..585	CDD:270470	4/33 (12%)
		M_domain	614..849	CDD:432890	42/268 (16%)
		TNRC6-PABC_bdg	844..1117	CDD:465195	67/280 (24%)
		RRM_GW182_like	1116..1185	CDD:409869	44/68 (65%)
tnrc6bb.1	NP_001429597.1	None