Protein Alignment gw and TNRC6A

DIOPT Version :10

• Sequence 1: NP_726596.1
• Gene: gw / 43808
• FlyBaseID: FBgn0051992
• Length: 1384
• Species: Drosophila melanogaster
• Sequence 2: XP_024305999.1
• Gene: TNRC6A / 27327
• HGNCID: 11969
• Length: 1971
• Species: Homo sapiens
• Alignment Length: 1450
• Identity: 385/1450 - (26%)
• Similarity: 566/1450 - (39%)
• Gaps: 389/1450 - (26%)

  Fly     5 LFSQDGWGCQHVNQDTNWEVPSSPEPANKDAPGPPMWKPS----INNGTDLWESNLRNGGQPAAQ 65
            :.|..|||...:.|:|.|:..:||....|...|...|..|    .|:|..: :....||...::.
Human   726 VLSNSGWGQTPIKQNTAWDTETSPRGERKTDNGTEAWGSSATQTFNSGACI-DKTSPNGNDTSSV 789

  Fly    66 Q---VPKPS--WGHTPSSNLGGTWGEDDDGADSSSVWTGGAVSNAGSGAAVGVNQAGVNVGPGGV 125
            .   .|||:  ||.:..||..|.| |||..|      ||...||
Human   790 SGWGDPKPALRWGDSKGSNCQGGW-EDDSAA------TGMVKSN--------------------- 826

  Fly   126 VSSGGPQWG----------------QGVVGVGLGSTGGNGSSNITGSSGVATGSSGNSSNAGNGW 174
                  |||                ||         .|:|..:..|.|..|:.:.|.:|. .|.|
Human   827 ------QWGNCKEEKAAWNDSQKNKQG---------WGDGQKSSQGWSVSASDNWGETSR-NNHW 875

  Fly   175 GDPREIRPLGVGGSMDIRNVEHRGGNGSGATSSDPRDIRMIDPRDPIRGDPRGISGRLNGT---- 235
            |:..  :....|||...|:|.  |.|..|.|||......:         :|...||....:
Human   876 GEAN--KKSSSGGSDSDRSVS--GWNELGKTSSFTWGNNI---------NPNNSSGWDESSKPTP 927

  Fly   236 SEMWGHHPQMSHNQLQGINKMVGQSVATASTSVGTS-----------GS-GIGPG---GPGPSTV 285
            |:.||..|:.:            ||:....:|...|           || ||.|.   .||...:
Human   928 SQGWGDPPKSN------------QSLGWGDSSKPVSSPDWNKQQDIVGSWGIPPATGKPPGTGWL 980

  Fly   286 SGNIPTQWGPAQPVSVGVSGPKDMSKQISGWEEPSPPPQRRSIPNYDDGTSLWGQQTRVPAASGH 350
            .|.||   .||:            .::.:|||||||...||.: ..|||||.||..::.     :
Human   981 GGPIP---APAK------------EEEPTGWEEPSPESIRRKM-EIDDGTSAWGDPSKY-----N 1024

  Fly   351 WKDMTDSIGRSSHLMRGQSQTGGIGIAGVGNSNVPVGANPSNPISSVVGPQARIPSVGGVQHKPD 415
            :|::                       .:.|.|||.|.:.|:..:.|  .|...|:......:..
Human  1025 YKNV-----------------------NMWNKNVPNGNSRSDQQAQV--HQLLTPASAISNKEAS 1064

  Fly   416 GGAMWVHSGNVGGRNNVAAVT------TWGDDTHS-VNVGAPSSGSVSSNNWVDDKSNSTLAQNS 473
            .|:.|   |...|..:..|.|      .||....| .:.|.|.:.:.|::.|    .:|::...:
Human  1065 SGSGW---GEPWGEPSTPATTVDNGTSAWGKPIDSGPSWGEPIAAASSTSTW----GSSSVGPQA 1122

  Fly   474 WSDPAPVGV--SWGNKQSKPPSNSASSGWSTAAGVVDGVDLGSEWNTHG---------------- 520
            .|...|..:  .|.......|.| ..:||...    :.|::|. ||::.
Human  1123 LSKSGPKSMQDGWCGDDMPLPGN-RPTGWEEE----EDVEIGM-WNSNSSQELNSSLNWPPYTKK 1181

  Fly   521 ----GIIGKSQQQQKLAGLNVGMVNVINAEIIKQSKQYRILVENGFKKEDVERALVIANMNIEEA 581
                |:.||.:::::  |:..|......|.|....||:..:   .|.::..|..:....|::  :
Human  1182 MSSKGLSGKKRRRER--GMMKGGNKQEEAWINPFVKQFSNI---SFSRDSPEENVQSNKMDL--S 1239

  Fly   582 ADMLRANSSLSMDGWRRHDESLGSYADHNSSTSSGGFAGRYPVNSGQPSMSFPHNNLMNNMGGTA 646
            ..||: :..:.:|   :|..::|   |:|.:...|  .|..|..|.:.||.  .|...:..|..|
Human  1240 GGMLQ-DKRMEID---KHSLNIG---DYNRTVGKG--PGSRPQISKESSME--RNPYFDKDGIVA 1293

  Fly   647 VTGGNNNTNMTALQVQKYLNQGQHGVAVGPQAVGNSSAVSVGFGQNTSNAAVAGAASVNIAANTN 711
                :.:.||..:..|. :.......|:..||:|:.:.:.:   ||.::....|..|:....||.
Human  1294 ----DESQNMQFMSSQS-MKLPPSNSALPNQALGSIAGLGM---QNLNSVRQNGNPSMFGVGNTA 1350

  Fly   712 NQPSGQQ-------------IR------MLGQQIQLAI-----HSGFISSQILTQPLTQTTLNLL 752
            .||.|.|             :|      :|..|:.:::     ::|.::.  |..|.....||.|
Human  1351 AQPRGMQQPPAQPLSSSQPNLRAQVPPPLLSPQVPVSLLKYAPNNGGLNP--LFGPQQVAMLNQL 1413

  Fly   753 NQL--LSNIKHLQ---------AAQQSLTRGGNV------NPMAVNVAISKYKQQIQNLQNQINA 800
            :||  ||.|..||         .:|:|:..|...      .|::|       :||:.....|::.
Human  1414 SQLNQLSQISQLQRLLAQQQRAQSQRSVPSGNRPQQDQQGRPLSV-------QQQMMQQSRQLDP 1471

  Fly   801 QQAVYVKQQNMQPTSQQQ---QPQQQQLPSVHLSNSGNDYLRGHDAINNLQSNF-----SELNIN 857
            .  :.||||.  |.||||   ||..:......:.::..:..:|...||.. |||     |.||:|
Human  1472 N--LLVKQQT--PPSQQQPLHQPAMKSFLDNVMPHTTPELQKGPSPINAF-SNFPIGLNSNLNVN 1531

  Fly   858 KPSGYQGASNQQSRLNQWKLPVLDK-EINSDSTEFSRAPGATKQNLTANTSNINSLGLQNDST-- 919
              .........||||.:|  ..:|. .:|:...:.|...||.........|........|.||
Human  1532 --MDMNSIKEPQSRLRKW--TTVDSISVNTSLDQNSSKHGAISSGFRLEESPFVPYDFMNSSTSP 1592

  Fly   920 WSTGRSIGDGWPDPSSDNENKDWSVAQPTSAATAYTDLVQEFEPGKPWKGSQIKSIEDDPSITPG 984
            .|...|||||||...|.|.:.  ||..|           .||.||:||||......|.||.:|||
Human  1593 ASPPGSIGDGWPRAKSPNGSS--SVNWP-----------PEFRPGEPWKGYPNIDPETDPYVTPG 1644

  Fly   985 SVARSPLSINSTPKDADIF--ANTGKNSP--TDLPPLSLSSSTWSF--NPNQNYPSHS------- 1036
            ||..: |||| |.::.|..  .|:|.:|.  |.||    |:|.||.  ..|.|.|..|
Human  1645 SVINN-LSIN-TVREVDHLRDRNSGSSSSLNTTLP----STSAWSSIRASNYNVPLSSTAQSTSA 1703

  Fly  1037 --------WSDNSQQCTATS-ELWTSPL---NKSSSRGPPPGLTANSNKSANSNASTPTTITGGA 1089
                    ||..|...|:.: |||..||   |.::...||||||......:..: ::|..|.|
Human  1704 RNSDSKLTWSPGSVTNTSLAHELWKVPLPPKNITAPSRPPPGLTGQKPPLSTWD-NSPLRIGG-- 1765

  Fly  1090 NGWLQPRSGGVQTTNTNWTGGNTTWGSS-------WLLLKNLTAQIDGPTLRTLCMQHGPLVSFH 1147
             ||        ..::..:|.| ::||.|       ||:|||||.||||.||||||||||||::||
Human  1766 -GW--------GNSDARYTPG-SSWGESSSGRITNWLVLKNLTPQIDGSTLRTLCMQHGPLITFH 1820

  Fly  1148 PYLNQGIALCKYTTREEANKAQMALNNCVLANTTIFAESPSENEVQSIM-QHLPQTPS-STSSSG 1210
            ..|..|.||.:|:::||..|||.:|:.|||.||||.||..||.|:.... |....||| ...|.|
Human  1821 LNLPHGNALVRYSSKEEVVKAQKSLHMCVLGNTTILAEFASEEEISRFFAQSQSLTPSPGWQSLG 1885

  Fly  1211 TSGGNVGGVG-----TSANNANSGSAACLSGNNSGNGNGSA--------------------SGAG 1250
            :|...:|.:.     :|..:.|..:.|.|||.|.|:.:|::                    .|..
Human  1886 SSQSRLGSLDCSHSFSSRTDLNHWNGAGLSGTNCGDLHGTSLWGTPHYSTSLWGPPSSSDPRGIS 1950

  Fly  1251 SGNNGNSSCNNSAAGGGSSS 1270
            |.:..|:..:....|||..|
Human  1951 SPSPINAFLSVDHLGGGGES 1970

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gw	NP_726596.1	Ago_hook	388..525	CDD:463088	30/165 (18%)
		UBA_GAWKY	551..585	CDD:270470	5/33 (15%)
		M_domain	614..849	CDD:432890	64/278 (23%)
		TNRC6-PABC_bdg	844..1117	CDD:465195	97/305 (32%)
		RRM_GW182_like	1116..1185	CDD:409869	44/75 (59%)
TNRC6A	XP_024305999.1	ser_rich_anae_1	<414..>702	CDD:468206
		ser_rich_anae_1	<631..>869	CDD:468206	45/186 (24%)
		Ago_hook	1084..1211	CDD:463088	25/138 (18%)
		M_domain	1304..1490	CDD:432890	48/202 (24%)
		TNRC6-PABC_bdg	1515..1776	CDD:465195	92/296 (31%)
		RRM_TNRC6A	1784..1875	CDD:410110	49/90 (54%)