DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gw and TNRC6B

DIOPT Version :9

Sequence 1:	NP_726596.1	Gene:	gw / 43808	FlyBaseID:	FBgn0051992	Length:	1384	Species:	Drosophila melanogaster
Sequence 2:	NP_001155973.1	Gene:	TNRC6B / 23112	HGNCID:	29190	Length:	1833	Species:	Homo sapiens

Alignment Length:	1451	Identity:	393/1451 - (27%)
Similarity:	547/1451 - (37%)	Gaps:	421/1451 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LFSQDGWGCQHVNQDTNWEVPSSPEPANKDAPGPPMWKPSINNGTDLWESNLRNGGQPAAQQVPK 69
            :.|..|||...:.|||.|::...|.|..|.           :.||:.|||       .|.|....
Human   617 VLSNTGWGQTQIKQDTVWDIEEVPRPEGKS-----------DKGTEGWES-------AATQTKNS 663

  Fly    70 PSWGHTP--SSNLGGTWGEDDDGADSSSVW-----TGG-------AVSNAGSGAAVGVNQAGVNV 120
            ..||..|  |:.:...|||    ..:|:.|     |||       ..||.|.|.......:..|.
Human   664 GGWGDAPSQSNQMKSGWGE----LSASTEWKDPKNTGGWNDYKNNNSSNWGGGRPDEKTPSSWNE 724

  Fly   121 GPGGVVS-SGGPQWGQGVVGVGLGSTGGNGSSNITGSSGVATGSSGNSSNAG---NGWGDPREIR 181
            .|..... .||.|..||      .|:|.||    .|.....|.:|...|:|.   :|||:
Human   725 NPSKDQGWGGGRQPNQG------WSSGKNG----WGEEVDQTKNSNWESSASKPVSGWGE----- 774

  Fly   182 PLGVGGSMDIRNVEHRGGNGSGATSSDPRDIRMIDPRDPIRGDPRGISGRLNGTSEMWG--HHPQ 244
                ||..:| .....|||.|.|:.....|.:    |.|...:    :||   ....|.  |..|
Human   775 ----GGQNEI-GTWGNGGNASLASKGGWEDCK----RSPAWNE----TGR---QPNSWNKQHQQQ 823

  Fly   245 MSHNQLQGINKMVGQSVATASTSVGTSGSGIGPGGPGPSTVSGNI---PTQW--GPAQPVSVGVS 304
            ....|             ........|||..||..|.|    ||:   .:.|  || ||.:
Human   824 QPPQQ-------------PPPPQPEASGSWGGPPPPPP----GNVRPSNSSWSSGP-QPAT---- 866

  Fly   305 GPKDMSKQISGWEEPSPPPQRRSIPNYDDGTSLWGQQTRVPAASGHWKDMTDSIGRSSHLMRGQS 369
             |||  ::.||||||||....|.: :.|||||.||...     |.::|::        :|....|
Human   867 -PKD--EEPSGWEEPSPQSISRKM-DIDDGTSAWGDPN-----SYNYKNV--------NLWDKNS 914

  Fly   370 QTGGIGIAGVGNSNVPVGANPSNPISSVVGPQARIPSVGGVQHKPDGGAMWVHSGNVGGRNNVAA 434
            |.|    ......|:|   .|....|:.|..::..|:       ||.|
Human   915 QGG----PAPREPNLP---TPMTSKSASVWSKSTPPA-------PDNG----------------- 948

  Fly   435 VTTWGDDTHSVNVGAPSSGSVSSNNW--VDDKSNSTLAQNSWSDPAPVGVSWGNKQS------KP 491
            .:.||:...            ||..|  :||...||             ..|||..:      ||
Human   949 TSAWGEPNE------------SSPGWGEMDDTGAST-------------TGWGNTPANAPNAMKP 988

  Fly   492 PSNSASSGWSTAAGVVDGV--------DLGSEWNTHG-------------GIIGKSQQQQKLAG- 534
            .|.|...||..:.|.|.|.        :.|..|||.|             |..||.|.:..|.|
Human   989 NSKSMQDGWGESDGPVTGARHPSWEEEEDGGVWNTTGSQGSASSHNSASWGQGGKKQMKCSLKGG 1053

  Fly   535 -------------LNVGMVNVINAEIIKQSKQYRILVENGFKKEDVERALVIANMNIEEAADMLR 586
                         .|:|:::  ..|....||....:.....||.||::..    ||:.:..|::|
Human  1054 NNDSWMNPLAKQFSNMGLLS--QTEDNPSSKMDLSVGSLSDKKFDVDKRA----MNLGDFNDIMR 1112

  Fly   587 ANSSLSMDGWRRHDE------SLGSYADHNS---STSSGGFAGRYPVNSGQPSMSF---PHNNLM 639
            .:.|    |:|..:.      ..|.|.:..:   |...|......|.:...||.|:   |..:.:
Human  1113 KDRS----GFRPPNSKDMGTTDSGPYFEKLTLPFSNQDGCLGDEAPCSPFSPSPSYKLSPSGSTL 1173

  Fly   640 NNMGGTAVTGGNNNTNMTALQVQKYLNQGQHGVAVGPQAVGNSSAVSVGFGQNTSNAAVAGAASV 704
            .|:...|:..|.|..|..|.|      .|.||:      .|||:|.|.|.
Human  1174 PNVSLGAIGTGLNPQNFAARQ------GGSHGL------FGNSTAQSRGL--------------- 1211

  Fly   705 NIAANTNNQPSGQQIRMLGQQIQLAIHSGFISSQILTQPLTQTTLNLLNQLLSNIKHLQAAQQSL 769
                :|..||......:..|     :...|||.|:....|.|...:.|:..|.|:
Human  1212 ----HTPVQPLNSSPSLRAQ-----VPPQFISPQVSASMLKQFPNSGLSPGLFNV---------- 1257

  Fly   770 TRGGNVNPMAVNV---------------AISKYKQQIQNLQNQINAQQAVYVKQQ----NMQPTS 815
              |..::|..:.:               .:.:.:||.|.||||....|||..:|:    .|....
Human  1258 --GPQLSPQQIAMLSQLPQIPQFQLACQLLLQQQQQQQLLQNQRKISQAVRQQQEQQLARMVSAL 1320

  Fly   816 QQQQPQQQQLPSVHLSNSGNDYLRGHDAINNLQSNFSELNINKP------------SGYQGA--- 865
            ||||.|||:.|.:..|.|.....:.|  ::|:..|  .||:..|            ||:...
Human  1321 QQQQQQQQRQPGMKHSPSHPVGPKPH--LDNMVPN--ALNVGLPDLQTKGPIPGYGSGFSSGGMD 1381

  Fly   866 --------SNQQSRLNQWK-----LP-VLDKEINSDSTEFSRAPGATKQNLTANTSNINSLGLQN 916
                    :..:||..||.     || |..:|.|........|||.|:.....|..:|    :..
Human  1382 YGMVGGKEAGTESRFKQWTSMMEGLPSVATQEANMHKNGAIVAPGKTRGGSPYNQFDI----IPG 1442

  Fly   917 DSTWSTGRSIGDGWPDPSSDNENKDWSVAQPTSAATAYTDLVQEFEPGKPWKGSQIKSIEDDPSI 981
            |:........||.|....|...||   :...:|.|:    ...||:||.||||.|....|.||.:
Human  1443 DTLGGHTGPAGDSWLPAKSPPTNK---IGSKSSNAS----WPPEFQPGVPWKGIQNIDPESDPYV 1500

  Fly   982 TPGSV----ARSPLSINSTPKDADIFAN--TGKNSP--TDLP-----PLSLS------------- 1020
            |||||    |.||:    ...|..:..:  ||.||.  |.||     |.|.|
Human  1501 TPGSVLGGTATSPI----VDTDHQLLRDNTTGSNSSLNTSLPSPGAWPYSASDNSFTNVHSTSAK 1561

  Fly  1021 ----SSTWSFNPNQNYPSHSWSDNSQQCTATSELWTSPLNKSSSRG------PPPGLTANSNKSA 1075
                .||||.:|..:.|:|          .::::|.   |..|||.      |||||| |...|:
Human  1562 FPDYKSTWSPDPIGHNPTH----------LSNKMWK---NHISSRNTTPLPRPPPGLT-NPKPSS 1612

  Fly  1076 NSNASTPTTITGGANGWLQPRSGGVQTTN----TNWTGGNTTWGSSWLLLKNLTAQIDGPTLRTL 1136
            ..:::.|.::    .||      |.|.:.    :.|:.|.:...|.||:|.|||.||||.||||:
Human  1613 PWSSTAPRSV----RGW------GTQDSRLASASTWSDGGSVRPSYWLVLHNLTPQIDGSTLRTI 1667

  Fly  1137 CMQHGPLVSFHPYLNQGIALCKYTTREEANKAQMALNNCVLANTTIFAESPSENEVQSIM-QHLP 1200
            |||||||::||..|.||.||.:|:|::||.|||.||:.|||.||||.||..:::||...: |..|
Human  1668 CMQHGPLLTFHLNLTQGTALIRYSTKQEAAKAQTALHMCVLGNTTILAEFATDDEVSRFLAQAQP 1732

  Fly  1201 QTPSSTSSSGTSGGNVGGVGTSANNANS-GSAACLSGNNSGNGNGSASGAGSGNNGNSSCNNSAA 1264
            .||::|.|:..:|..  .:.|..|.::. |.|..|.|.::|.|..|:|..||.....:..:....
Human  1733 PTPAATPSAPAAGWQ--SLETGQNQSDPVGPALNLFGGSTGLGQWSSSAGGSSGADLAGASLWGP 1795

  Fly  1265 GGGSSSNNTITTVANSNLVGS 1285
            ...|||...:.||.:.:.:||
Human  1796 PNYSSSLWGVPTVEDPHRMGS 1816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gw	NP_726596.1	Ago_hook	388..520	CDD:287408	32/147 (22%)
		UBA_GAWKY	551..585	CDD:270470	9/33 (27%)
		M_domain	613..848	CDD:289690	61/256 (24%)
		TNRC6-PABC_bdg	844..1068	CDD:293214	78/288 (27%)
		RRM_GW182_like	1116..1185	CDD:240881	45/68 (66%)
TNRC6B	NP_001155973.1	Interaction with argonaute proteins	1..994		134/524 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..98
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	126..164
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	205..350
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	367..1046		147/576 (26%)
		Ago_hook	945..1055	CDD:287408	35/151 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1193..1212		10/49 (20%)
		Silencing domain, interaction with CNOT1 and PAN3. /evidence=ECO:0000269\|PubMed:21981923	1218..1723		171/564 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1316..1346		11/29 (38%)
		TNRC6-PABC_bdg	1360..1645	CDD:293214	85/323 (26%)
		PABPC1-interacting motif-2 (PAM2)	1472..1490		10/21 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1590..1638		16/58 (28%)
		RRM_TNRC6B	1647..1729	CDD:241156	49/81 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1730..1763		9/34 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1809..1833		2/8 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	286	1.000	Inparanoid score	I2855
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001648
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13020
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X744
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	7.110