Protein Alignment gw and Tnrc6b

DIOPT Version :9

• Sequence 1: NP_726596.1
• Gene: gw / 43808
• FlyBaseID: FBgn0051992
• Length: 1384
• Species: Drosophila melanogaster
• Sequence 2: XP_017450134.1
• Gene: Tnrc6b / 192178
• RGDID: 621428
• Length: 1875
• Species: Rattus norvegicus
• Alignment Length: 1467
• Identity: 397/1467 - (27%)
• Similarity: 551/1467 - (37%)
• Gaps: 447/1467 - (30%)

  Fly     5 LFSQDGWGCQHVNQDTNWEVPSSPEPANKDAPGPPMWKPSINNGTDLWESNLRNGGQPAAQQVPK 69
            :.|..|||...:.|||.|::...|.|..|.           :.||:.|||       .|.|....
  Rat   653 VLSNTGWGQTQIKQDTVWDIEEVPRPEGKS-----------DKGTEGWES-------AATQTKNS 699

  Fly    70 PSWGHTP--SSNLGGTWGEDDDGADSSSVW-----TGGAVSNAGSGAAVGVNQAGVNVGPGGVVS 127
            ..||..|  |:.:...|||    ..:|:.|     |||.                     ....:
  Rat   700 GGWGDAPSQSNQMKSGWGE----LSASTEWKDPKSTGGW---------------------NDYKN 739

  Fly   128 SGGPQWGQGVVGVGLGSTGGNGSSNITGSSGVATGSSGNSSNAG-----NGWGDP---------- 177
            :....||.|.......|:....|....|..|      |...|.|     ||||:.
  Rat   740 NNSSNWGGGRADEKTPSSWNESSCKDQGWGG------GRQPNQGWTSGKNGWGEEVDQVKNNNWE 798

  Fly   178 ----REIRPLGVGGSMDIRNVEHRGGNGSGATSSDPRDIRMIDPRDPIRGDPRGISGRLNGTSEM 238
                :.:...|.||..:| .....|||.:.|:.....|.:    |.|...:    :||   ....
  Rat   799 SSANKPVSGWGEGGQSEI-GTWGNGGNTNLASKGGWEDCK----RSPAWNE----TGR---QPNS 851

  Fly   239 WGHHPQMSHNQLQGINKMVGQSVATASTSVGTSGSGIGPGGPGPSTVSGNI---PTQW--GPAQP 298
            |....|....|             ........|||.   ||| |....||:   .:.|  || ||
  Rat   852 WNKQHQQQQQQ-------------PPPPQPEASGSW---GGP-PPPPQGNVRPSNSNWSSGP-QP 898

  Fly   299 VSVGVSGPKDMSKQISGWEEPSPPPQRRSIPNYDDGTSLWGQQTRVPAASGHWKDMTDSIGRSSH 363
            .:     |||  .:.||||||||....|.: :.|||||.||...     |.::|::        :
  Rat   899 AT-----PKD--DEPSGWEEPSPQSISRKM-DIDDGTSAWGDPN-----SYNYKNV--------N 942

  Fly   364 LMRGQSQTGGIGIAGVGNSNVPVGANPSNPISSVVGPQARIPSVGGVQHKPDGGAMWVHSGNVGG 428
            |....||.|            |....|:.| :.:.|..|.:.| ......||.|
  Rat   943 LWDKNSQGG------------PAPREPNLP-TPMTGKSASVWS-KSTPPAPDNG----------- 982

  Fly   429 RNNVAAVTTWGDDTHSVNVGAPSSGSVSSNNW--VDDKSNSTLAQNSWSDPAPVGVSWGNKQS-- 489
                  .:.||:...            ||..|  :||...|             ...|||..:
  Rat   983 ------TSAWGEPNE------------SSPGWGEMDDAGAS-------------ATGWGNTPASA 1016

  Fly   490 ----KPPSNSASSGWSTAAGVVDGV--------DLGSEWNTHG-------------GIIGKSQQQ 529
                ||.|.|...||..:.|.|.|.        |.|..|||.|             |..||.|.:
  Rat  1017 PNAMKPNSKSMQDGWGESDGPVTGARHPSWEEEDDGGVWNTAGSQGSTSSHNSASWGQGGKKQMK 1081

  Fly   530 QKLAGLNVGMVNVI-----NAEIIKQ-----SKQYRILVENGFKKEDVERALVIANMNIEEAADM 584
            ..:.|.|...:|.:     |..::.|     |.:..:.|:   ||.||::    ..||:.:..|:
  Rat  1082 CSIKGNNDSWMNPLAKQFSNMGLLSQTEDNPSSKMDLSVD---KKFDVDK----RTMNLGDFNDI 1139

  Fly   585 LRANSSLSMDGWR-RHDESLGS-----YADHNS---STSSGGFAGRYPVNSGQPSMSF---PHNN 637
            :|.:    ..|:| .:.:.||:     |.:..:   |...|......|.:...||.|:   |..:
  Rat  1140 MRKD----RPGFRPPNSKDLGTTDSGPYFEKLTLPFSNQDGCLGDEAPCSPFSPSPSYKLSPSGS 1200

  Fly   638 LMNNMGGTAVTGGNNNTNMTALQVQKYLNQGQHGVAVGPQAVGNSSAVSVGFG---QNTSNAAVA 699
            .:.|:...|:..|.|..|..|.|      .|.||:      .|||:|.|.|..   |..|::...
  Rat  1201 TLPNVSLGAIGTGLNPQNFAARQ------GGSHGL------FGNSTAQSRGLHTPVQPLSSSPGL 1253

  Fly   700 GA------ASVNIAA----------------NTNNQPSGQQIRMLGQ-----QIQLAIHSGFISS 737
            .|      .|..::|                |...|.|.|||.||.|     |.|||       .
  Rat  1254 RAQVPPQFISPQVSASMLKQFPNSGLNPGLFNVGPQLSPQQIAMLSQLPQIPQFQLA-------C 1311

  Fly   738 QILTQPLTQTTLNLLNQLLSNIKHL-QAAQQSLTRGGNVNPMAVNVAISKYKQQIQNLQNQINAQ 801
            |:|.|...|      .|||.|.:.: ||.:|                  :.:||:..:.:.:..|
  Rat  1312 QLLLQQQQQ------QQLLQNQRKISQAVRQ------------------QQEQQLARMVSALQQQ 1352

  Fly   802 QAVYVKQQNMQPTSQQQQPQQQQLPSVHLSNSGNDYLRGHDAINNLQSNFSELNINKP------- 859
            |    :||..|...||||.|||:.||:..|.|.....:.|  ::|:..|  .||:..|
  Rat  1353 Q----QQQQQQQQQQQQQQQQQRQPSMKHSPSHPVGPKPH--LDNMVPN--TLNVGLPDLPTKGP 1409

  Fly   860 -----SGYQGA-----------SNQQSRLNQWK-----LP-VLDKEINSDSTEFSRAPGATKQNL 902
                 ||:...           :..:||..||.     || |..:|..........|||.|:...
  Rat  1410 IPGYGSGFSSGGMDYGMVGGKEAGTESRFKQWTSMMEGLPSVATQEATMHKNGAIVAPGKTRGGS 1474

  Fly   903 TANTSNINSLGLQNDSTWSTGRSIGDGWPDPSSDNENKDWSVAQPTSAATAYTDLVQEFEPGKPW 967
            ..|..:|    :..|:........||.|....|...||   :...:|.|:    ...||:||.||
  Rat  1475 PYNQFDI----IPGDTLGGHTGPAGDSWLPAKSPPTNK---IGSKSSNAS----WPPEFQPGVPW 1528

  Fly   968 KGSQIKSIEDDPSITPGSV----ARSPLSINSTPKDADIFAN--TGKNSP--TDLP-----PLSL 1019
            ||.|....|.||.:|||||    |.||:    ...|..:..:  ||.||.  |.||     |.|.
  Rat  1529 KGIQNIDPESDPYVTPGSVLGGTATSPI----VDTDHQLLRDNTTGSNSSLNTSLPSPGAWPYSA 1589

  Fly  1020 S-----------------SSTWSFNPNQNYPSHSWSDNSQQCTATSELWTSPLNKSSSRG----- 1062
            |                 .||||.:|..:.|:|          .::::|.   |..|||.
  Rat  1590 SDNSFTNVHSTSAKFPDYKSTWSPDPIGHNPTH----------LSNKMWK---NHISSRNTTPLP 1641

  Fly  1063 -PPPGLTANSNKSANSNASTPTTITGGANGWLQPRSGGVQTTN----TNWTGGNTTWGSSWLLLK 1122
             |||||| |...::..:::.|.::    .||      |.|.:.    :.|:.|.:...|.||:|.
  Rat  1642 RPPPGLT-NPKPASPWSSTAPRSV----RGW------GTQDSRIASASTWSDGGSVRPSYWLVLH 1695

  Fly  1123 NLTAQIDGPTLRTLCMQHGPLVSFHPYLNQGIALCKYTTREEANKAQMALNNCVLANTTIFAESP 1187
            |||.||||.||||:|||||||::||..|.||.||.:|:|::||.|||.||:.|||.||||.||..
  Rat  1696 NLTPQIDGSTLRTICMQHGPLLTFHLNLTQGTALIRYSTKQEAAKAQTALHMCVLGNTTILAEFA 1760

  Fly  1188 SENEVQSIM-QHLPQTPSSTSSSGTSGGNVGGVGTSANNANS-GSAACLSGNNSGNGNGSASGAG 1250
            :|:||...: |..|.||::|.|:..:|..  .:.||.|.|:. |.|..|.|.::|.|..|:|..|
  Rat  1761 TEDEVSRFLAQAQPPTPAATPSAPATGWQ--SLETSQNQADPVGPALNLFGGSTGLGQWSSSAGG 1823

  Fly  1251 SGNNGNSSCNNSAAG--GGSSSNNTITTVANSNLVGS 1285
            |  :|......|..|  ..|||...:.||.:.:.:||
  Rat  1824 S--SGADLAGTSLWGPPNYSSSLWGVPTVEDPHRMGS 1858

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gw	NP_726596.1	Ago_hook	388..520	CDD:287408	33/147 (22%)
		UBA_GAWKY	551..585	CDD:270470	9/33 (27%)
		M_domain	613..848	CDD:289690	71/268 (26%)
		TNRC6-PABC_bdg	844..1068	CDD:293214	77/288 (27%)
		RRM_GW182_like	1116..1185	CDD:240881	45/68 (66%)
Tnrc6b	XP_017450134.1	Ago_hook	956..1098	CDD:371044	41/185 (22%)
		TNRC6-PABC_bdg	1406..1687	CDD:406905	82/319 (26%)
		RRM_TNRC6B	1689..1771	CDD:410111	50/81 (62%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	285	1.000	Inparanoid score	I2767
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001648
OrthoInspector	1	1.000	-	-		otm45319
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13020
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X744
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.150