Protein Alignment gw and tnrc6c2

DIOPT Version :9

• Sequence 1: NP_726596.1
• Gene: gw / 43808
• FlyBaseID: FBgn0051992
• Length: 1384
• Species: Drosophila melanogaster
• Sequence 2: XP_009300640.2
• Gene: tnrc6c2 / 100149391
• ZFINID: ZDB-GENE-061207-48
• Length: 1571
• Species: Danio rerio
• Alignment Length: 1441
• Identity: 377/1441 - (26%)
• Similarity: 544/1441 - (37%)
• Gaps: 421/1441 - (29%)

  Fly    10 GWGCQHVNQDTNWEVP---------------SSPEPANKDAPGPPMWKPSINNGTDLWESNLRNG 59
            |||...|.|.|.||:.               ||...|:.:.|.||   |...|      ||:
Zfish   300 GWGQTPVRQHTVWEMEASTDKKNDVGTEDWGSSSNTASTEPPPPP---PGCAN------SNI--- 352

  Fly    60 GQPAAQQVPKPSWGH---TPSSNLGGT----------WGEDDDGADSSSVWTGGAVSNAGSGAAV 111
             .|..:.....|.||   .|::..||:          |||.......|:    |:..|.|....|
Zfish   353 -SPPPRMDTSKSEGHCRVMPNAGWGGSVPVSAQPNSGWGEPSANKKVSN----GSGCNWGDPNPV 412

  Fly   112 GVNQAGVNVGPGGVVSSGGPQWGQGVVGVGLGSTG-GNGSSNITGSSGVATGSSGNSSNAGNGWG 175
            ..|.:|.| |.........|.|..........:.| |..||:..||||.|        |:|. ||
Zfish   413 APNISGCN-GQSWASEEKSPSWNDCTSQKTTQNWGDGPKSSSGWGSSGCA--------NSGE-WG 467

  Fly   176 DPREIRPLGVGGSMDIRNVEHRGGNGSGATSSDPRDIRMIDPR------DPIRGDPRGISGRLNG 234
            :..|::                  |.||::|.:|...:..:.:      .|.:....|.:...||
Zfish   468 ESSEMK------------------NSSGSSSWEPDSRKCKETQRGWTKASPAQSGCWGEAQHTNG 514

  Fly   235 TSEMWGHHPQMSHNQLQGINKMVGQSVATASTSVGTSGSGIGPGGPGPSTVSGNIPTQWGPAQPV 299
            :::.||...|.|         |.|.:               |.||.|          .||....|
Zfish   515 STQGWGGKLQES---------MCGNN---------------GSGGIG----------SWGGPNSV 545

  Fly   300 SVGVSG-----PKDMSKQISGWEEPSPPPQRRSIPNYDDGTSLWGQQTRVPAASGHWKDMTDSIG 359
            ....||     .::...:.:|||||||...||.: :.|||||.||.    |:|.....:|.|
Zfish   546 KQSNSGWSSRCRQETGDESTGWEEPSPSSVRRKM-DIDDGTSTWGD----PSAYSKSVNMWD--- 602

  Fly   360 RSSHLMRGQSQT-GGIGIAGVGNS-NVPVGANPSNPISSVVGPQARIPSVGGVQHKPDGGAMWVH 422
                  |..||. .|...:|.||: :||..||         .||.:.|:
Zfish   603 ------RNHSQNHPGTNNSGNGNNLSVPNSAN---------HPQRQGPT---------------- 636

  Fly   423 SGNVGGRNNVAAVTT--------------WGD------DTHSVNVGAPSSGSVSSNNWVDDKSNS 467
            ..:|.|.||.|:.:.              ||:      :|...:.|..:|.|.|.:|.......|
Zfish   637 QNHVSGSNNNASPSQGECPLNRISMVNPGWGEIPKVQPNTEPSSWGETASSSSSVDNGTSAWGQS 701

  Fly   468 TLAQNSWSD------------------------PAPVGVSWGNKQSKPPSNSASSGWSTAAGVVD 508
            :..:..||:                        |.|:...||:...:...|  :|.|:
Zfish   702 SRGRGGWSEGSRDSSGSYGRGNAPAVSSPCQEGPKPMQDGWGSGGEEMGMN--TSQWN------- 757

  Fly   509 GVDLGSEWNT---------HGGIIGKSQQQQKLAGL--NVGMVNVINAEIIKQSKQYRILVENGF 562
             .|.|..||:         ..|...|..|:.|::..  :|.::|    .:|||      |.:.||
Zfish   758 -ADDGDMWNSPTSQDSTCNSWGHSRKGPQRVKVSNKQDDVWIMN----RLIKQ------LTDMGF 811

  Fly   563 KKEDVERALVIANMNIEEA-ADMLRANSSLSMDGWRRHDESLG---------------SYADH-- 609
            .|:..|.||...|||:::| :.:|...:.|...|....|.|.|               |..||
Zfish   812 PKDPAEEALKSNNMNLDQAMSALLEKKNELDKRGMGTSDYSNGLNKPMVCRPTNLSKDSSLDHSP 876

  Fly   610 --------NSSTSSGGFAGRYPVNSGQPSMSFPHNNLMNNMGGTAVTGGNNNTNMTALQVQKYLN 666
                    :..:||..|.....:.....|.|.|::.|    ||.:          :.|.:|...|
Zfish   877 FLDKDGRLSDDSSSSPFMPSPGLKLPLASSSLPNHGL----GGVS----------SGLSMQNLNN 927

  Fly   667 QGQH-GVAVGPQAVGNSSAVSVGFGQNTSNAAVAGAASVNIAAN------------TNNQPS--G 716
            :..| |:                ||.|       |||...:...            ::.||:  .
Zfish   928 RQMHNGM----------------FGTN-------GAAQTRVMQQQAPPPQPPVPPLSSTQPNLRA 969

  Fly   717 QQIRML-----GQQIQLAIHSGFISSQILTQPLT---QTTLNLLNQLLSNIKHLQAAQQSLTRGG 773
            |..::|     .|.:|.|..:..::..:||.|:.   .|.|..|.||....:.||..||.:....
Zfish   970 QVPQLLTPQVQAQLLQFAAKNIGLNPALLTSPINPQQMTLLYQLQQLQVAYQRLQIQQQMMQAQR 1034

  Fly   774 NVN------PMAVNVAISKYKQQIQNLQNQINAQQAVYVKQQNMQPTSQQQQPQQQQLPSVHLSN 832
            ||:      ...|...|:..:||||..|.|:  .||:.:|||...|:|.....|       :|..
Zfish  1035 NVSGPIKQQEQQVARTITNMQQQIQQHQRQL--AQALLMKQQQPPPSSHTGLHQ-------NLGK 1090

  Fly   833 SGNDYLRGHDAIN-NLQSNFSE---LNINKPSGYQGASNQQSRLNQWKLPVLDKEINS-DSTEFS 892
            :..|....  .:| |:..|..|   |::..|      ...||||:||..|      || ||..
Zfish  1091 ASQDSFTA--GLNPNMNVNCMEVGSLSLKDP------PQPQSRLSQWTHP------NSIDSLT-- 1139

  Fly   893 RAPGATKQNLTANTSNINSLGLQNDSTWSTGRSIGDGWP--DPSSDNENKDWSVAQPTS------ 949
                |:.|::.||.|...|:........:...|:.|.:.  :..|.:|:...::..|.|
Zfish  1140 ----ASTQHMEANLSKHGSISAAQSHVPAGKSSMEDSFSPYNMMSSSESPSNTLVSPESWTQGKS 1200

  Fly   950 -----AATAYTDLVQEFEPGKPWKGSQIKSIEDDPSITPGSVARSPLSINSTPKDADIFA---NT 1006
                 |:.:......||.||.||||.|....|:||::|||||...| :||:..:|.:.:.   .|
Zfish  1201 PNEKIASGSNISWPPEFCPGVPWKGLQNIDPENDPNMTPGSVPNGP-TINTNIQDVNRYLLRDRT 1264

  Fly  1007 GKNSPTDLPPLSLSSSTWS---------FNPNQNYPSH---------SWSD---NSQQCTATSEL 1050
            |.:||:....|| ||:.||         |:.|:....:         :||.   :..|.:.:.||
Zfish  1265 GASSPSQSGTLS-SSNDWSDSAFNSLALFSQNERDAENPGKLLEMKSTWSPGPISHTQASLSQEL 1328

  Fly  1051 W-TSP--LNKSSSRGPPPGLTANSNKSANSNASTPTTITGGANGWLQPRSGGVQTTNTNWTGGNT 1112
            | .||  .|.|:...||||||         |....:|..|.:.|..|..:....:....|:..:.
Zfish  1329 WKVSPGTRNSSAPSRPPPGLT---------NTKPSSTWGGNSLGLSQGWNNSYSSEGGTWSSDSP 1384

  Fly  1113 TWGSSWLLLKNLTAQIDGPTLRTLCMQHGPLVSFHPYLNQGIALCKYTTREEANKAQMALNNCVL 1177
            ..|||||:|:|||.||||.||||||||||||::||..|.||.|:.:|:::|||.|||.:|:.|||
Zfish  1385 NRGSSWLVLRNLTPQIDGSTLRTLCMQHGPLITFHLNLTQGNAVVRYSSKEEAAKAQKSLHMCVL 1449

  Fly  1178 ANTTIFAESPSENEVQSIM---QHLPQT------PSSTSSSGTSGGNVGGVGTSANNANSGSAAC 1233
            .||||.||..||.:|....   |.|..|      |:..||....|.......|...:...|:...
Zfish  1450 GNTTILAEFASEEDVNRFFAQGQSLTPTTSWQASPAPGSSQPRLGNPTASHPTGLWSGGGGTKTV 1514

  Fly  1234 LSGNNSGNGNG 1244
            .|..||.:|||
Zfish  1515 CSAGNSSSGNG 1525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gw	NP_726596.1	Ago_hook	388..520	CDD:287408	32/184 (17%)
		UBA_GAWKY	551..585	CDD:270470	11/34 (32%)
		M_domain	613..848	CDD:289690	61/264 (23%)
		TNRC6-PABC_bdg	844..1068	CDD:293214	77/268 (29%)
		RRM_GW182_like	1116..1185	CDD:240881	45/68 (66%)
tnrc6c2	XP_009300640.2	UBA_TNR6C	800..837	CDD:270469	16/46 (35%)
		M_domain	880..1097	CDD:315593	59/262 (23%)
		TNRC6-PABC_bdg	1098..1387	CDD:318749	85/319 (27%)
		RRM_TNRC6C	1388..1470	CDD:241157	50/81 (62%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	292	1.000	Inparanoid score	I2766
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001648
OrthoInspector	1	1.000	-	-		otm24990
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13020
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X744
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	7.150