DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ekar and GLR3.4

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_001030971.1	Gene:	GLR3.4 / 839268	AraportID:	AT1G05200	Length:	959	Species:	Arabidopsis thaliana

Alignment Length:	950	Identity:	209/950 - (22%)
Similarity:	376/950 - (39%)	Gaps:	213/950 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 PPLVRIGAIFSNQPGMYNSEL------AFRYAIHRLNMDKSLLPETTVDYYVEYVNRFDSFETVQ 78
            |..|.:||:|:     |:|.:      |.:.|:..:|.|:|:|....::...:..| ...|....
plant    58 PSSVNVGALFT-----YDSFIGRAAKPAVKAAMDDVNADQSVLKGIKLNIIFQDSN-CSGFIGTM 116

  Fly    79 KVCKLIRVGVQAVFSPTDSVLATHINSICDALDIPNIGRSAHD---------FSINVYPSKQLVN 134
            ...:|:...|.|...|..|.:|..|:.:.:.|.:|.:...|.|         :.:....:.....
plant   117 GALQLMENKVVAAIGPQSSGIAHMISYVANELHVPLLSFGATDPTLSSLQFPYFLRTTQNDYFQM 181

  Fly   135 YAFNDVIQYLNWTR-FGILHEKE---NGIINLHQLSRSFHGEVHMRQVSRDSYVSALNE-FKGKE 194
            :|..|.:.|..|.: ..|..:.|   |||        |..|:|..::.||.||.:|:.. .....
plant   182 HAIADFLSYSGWRQVIAIFVDDECGRNGI--------SVLGDVLAKKRSRISYKAAITPGADSSS 238

  Fly   195 IHNIIIDTN-------------SNGISIL-LKNILQQQMNEYKY---HYLFTSFD-LETYDLEDF 241
            |.::::..|             .:|:::. :...|....:.|.:   .:|.|:.| :|..|
plant   239 IRDLLVSVNLMESRVFVVHVNPDSGLNVFSVAKSLGMMASGYVWIATDWLPTAMDSMEHVD---- 299

  Fly   242 KYNFVNITSFRLVDTADVGVKQILKDIGLYSHHIF----KKPYLN--LHIKKSTILESEPALMFD 300
                        .||.|     :|:.:..:.|:..    |:.::.  .:::.:....|.....:|
plant   300 ------------SDTMD-----LLQGVVAFRHYTIESSVKRQFMARWKNLRPNDGFNSYAMYAYD 347

  Fly   301 SVYVFAIGLQT-LEQSHSLTLLN-----------ISCEEENSWDGGLSLINYLNAVEWKGLTGPI 353
            ||::.|..|.. ..:::::|..|           |.....:.::.|...:..:..:...|:||||
plant   348 SVWLVARALDVFFRENNNITFSNDPNLHKTNGSTIQLSALSVFNEGEKFMKIILGMNHTGVTGPI 412

  Fly   354 QF-KDGQRVQFKLDLIKLKQHSIVKVGEWTPHGHLNITEPSMFF----DAGSMNVTLVVI----T 409
            || .|..||....:::.|:..:...||.|:.|..|::..|...:    :..:.|..|..|    .
plant   413 QFDSDRNRVNPAYEVLNLEGTAPRTVGYWSNHSGLSVVHPETLYSRPPNTSTANQRLKGIIYPGE 477

  Fly   410 ILETP--YVMMHYGK-------------NFTGNER----FYGFCVDILETISREVGFDYILDLVP 455
            :.:.|  :|..:.||             ::...::    ..|:|:|:         |:..::|:|
plant   478 VTKPPRGWVFPNNGKPLRIGVPNRVSYTDYVSKDKNPPGVRGYCIDV---------FEAAIELLP 533

  Fly   456 ---DRKY-----GAKDPETGEWNGMVAQLMKYKADLAVGSMTITYARESVIDFTKPFMNLGISIL 512
               .|.|     |.::|   .::.:|.:::....|:|||.:||...|...:|||:||:..|:.::
plant   534 YPVPRTYILYGDGKRNP---SYDNLVNEVVADNFDVAVGDITIVTNRTRYVDFTQPFIESGLVVV 595

  Fly   513 --FKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEWKCINACDLENISIGN 575
              .|...|.|   :||:.|..||:|......:..|...::|                ||: ....
plant   596 APVKEAKSSP---WSFLKPFTIEMWAVTGGFFLFVGAMVWI----------------LEH-RFNQ 640

  Fly   576 QF------SLTDSFWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTER 634
            :|      .|...|||:..|......:....::. |.:...|.|..|||.:||||:|.:.||..:
plant   641 EFRGPPRRQLITIFWFSFSTMFFSHRENTVSSLG-RFVLIIWLFVVLIINSSYTASLTSILTIRQ 704

  Fly   635 MINPIENAEDLASQTEISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFT-----TTYED 694
            :.:.||..:.|.:..| ..|..|.    ||.|:.:|...        |..||...     ..|..
plant   705 LTSRIEGIDSLVTSNE-PIGVQDG----TFARNYLINEL--------NILPSRIVPLKDEEQYLS 756

  Fly   695 GIKR-VNQGNYAFLMESTMLDYI----VQRDCNLTQIGGLLDTKGYGIATPKGSPWRDKISLAIL 754
            .::| .|.|..|.:::.  |.||    ...:|....:|......|:|.|..:.||....:|.|||
plant   757 ALQRGPNAGGVAAIVDE--LPYIEVLLTNSNCKFRTVGQEFTRTGWGFAFQRDSPLAVDMSTAIL 819

  Fly   755 ELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFEFW 819
            :|.|.|:::.::.||.....|...:.:.|:.|:   |.|:|..|:|  ||.||.....:..| ||
plant   820 QLSEEGELEKIHRKWLNYKHECSMQISNSEDSQ---LSLKSFWGLF--LICGITCFMALTVF-FW 878

  Fly   820 YNFRYNYEATPSQSVVNNKYNQDGILESER--NYTPPDRS 857
            ..| :.|:....:|.           :.||  ..:.|.||
plant   879 RVF-WQYQRLLPESA-----------DEERAGEVSEPSRS 906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	82/420 (20%)
		ANF_receptor	39..371	CDD:279440	72/388 (19%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	100/417 (24%)
		Lig_chan	533..807	CDD:278489	72/289 (25%)
GLR3.4	NP_001030971.1	PBP1_GABAb_receptor_plant	62..450	CDD:380645	83/422 (20%)
		Periplasmic_Binding_Protein_Type_2	<518..591	CDD:389745	23/84 (27%)
		Lig_chan	615..869	CDD:365843	74/291 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.810