DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ekar and GLR1.3

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_199652.1	Gene:	GLR1.3 / 834896	AraportID:	AT5G48410	Length:	860	Species:	Arabidopsis thaliana

Alignment Length:	833	Identity:	164/833 - (19%)
Similarity:	299/833 - (35%)	Gaps:	229/833 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 GILHEKEN-GIINLHQ-LSRSFHGEVHMRQVSRDSYVSALNEFKGKEIHNIIIDTNSNGISILLK 212
            |.|.||.. .:|:|.. .|.|.....|:.|.:.||    .:|.||......:.|.||..
plant   123 GELGEKARVPMISLDSPFSLSLSKYTHLIQATHDS----TSEAKGITSFINVFDWNSVA------ 177

  Fly   213 NILQQQMNEYKYHYLFTSFDLETYDL--EDFKYNFVNITS---FRLVDTAD--VGVKQILKDIG- 269
             ::.:..::::          |:..|  |.|..|.|.:.|   |.:..:.|  :|..|.|||:|
plant   178 -LVYEDHDDWR----------ESMQLLVEHFHENGVRVQSKVGFTVSSSEDFVMGRLQQLKDLGT 231

  Fly   270 ---------LYSHHIF------------------KKPYLNLH--IKKSTILESEPALMFDSVYVF 305
                     :.:.|:|                  .|...:.|  |...|....|..:.|.|....
plant   232 TVFVVHLSEVIATHLFPCARRLGLMGDGFVWILTAKTMNSFHENIDDFTKQAMEGVVGFKSYIPM 296

  Fly   306 AIGLQ--TLE-------QSHSLTLLNISCEEENSWDGGL------------------SLINYLNA 343
            :|.||  ||.       :...||.|:||    ..|...:                  :|:..:..
plant   297 SIELQNFTLRWRKSLPVEEAELTRLSIS----GIWAHDIAFALARAAEVIRMPNVTSTLLEEITK 357

  Fly   344 VEWKGLTGPIQFKDGQRVQFKLDLIKLKQHSIVKVGEWTPHG------HLNITEPSM-------- 394
            ..:.||:|..|..|.:.:..|.::|.:...|..:||....:|      ||:.|...:
plant   358 TRFNGLSGDFQLNDKKLLSNKFEIINMIGSSERRVGFLNSNGSFSNRRHLSSTHNKLETIIWPGG 422

  Fly   395 ---------FFDAGSMNVTLVVITILETPYVMMHYGKNFTGNERFYGFCVDILE-TISREVGFDY 449
                     ..|:....:.::|.:....|.:|.......|......|||:::.. :||   .|:|
plant   423 SAQSPKGTSLIDSDRKKLRVLVTSSNRFPRLMKVETDPVTNELIVEGFCIEVFRASIS---PFNY 484

  Fly   450 ILDLVPDRKYGAKDPETGEW-NGMVAQLMKY-------KADLAVGSMTITYARESVIDFTKPFMN 506
            .::.:|             | ||.....:.|       |.|.|||.:|||..|.:.:|||.||..
plant   485 EVEYIP-------------WLNGSNYDNLAYALHSQKDKYDAAVGDITITSNRSTYVDFTLPFTE 536

  Fly   507 LGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEWKCINACDLENI 571
            :|:.|   |...|.: ::.|..||..::||.....:.|..:.::::.:....|::.
plant   537 MGLGI---VAVKERS-MWVFFQPLTPDLWITSAFFFVLTGVIVWLIERAENKEFQG--------- 588

  Fly   572 SIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERM- 635
            |...|..:.  .||...|.:....:.....:| |.:.:.|.|..||:.|||||.|.:.:|.:::
plant   589 SWPQQIGVV--LWFGFSTLVYAHREKLKHNLS-RFVVTVWVFAVLILTASYTATLTSMMTVQQIR 650

  Fly   636 INPIENAEDLASQTEISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYEDGIKRVN 700
            .|..|:.....|.:.|:...|.|.|.             :..||:              |:.  :
plant   651 FNSNEDYVGHLSGSLIANVALTSSSL-------------RAMRSL--------------GLN--S 686

  Fly   701 QGNYAFLMESTMLDYIV-----------QRDCNLTQIGGLLDTKGYGIATPKGSPWRDKISLAIL 754
            ..:||..:.:..:.::|           :...:...:.....|.|:|....||......:|..|.
plant   687 AADYAQALLNKTVSFVVDELPYLKVVLGENPTHFFMVKTQSTTNGFGFMFQKGFELVPNVSREIS 751

  Fly   755 ELQERGDIQMLYDKWWKN-----TDETCTRKNTSKQSKANSLGLESIGGVFVVL----IAGIIVA 810
            :|:....:..:..:|:.|     ||:|           :|.:.|....|:|:::    ...:.|.
plant   752 KLRTSEKLNEMEKRWFDNQLPYTTDDT-----------SNPITLYRFRGLFIIIGVSFAFALAVL 805

  Fly   811 AVVAFFEFW-------------YNFRYNYEATPSQSVVNNKYNQDGILESERN 850
            .::...:.|             .:||.::..:...|.:::...:..:..:::|
plant   806 VILCLRDKWEILVDNLDLSQRLRHFRIHFVRSIHTSPLDDPIGETAVQMAQQN 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	66/309 (21%)
		ANF_receptor	39..371	CDD:279440	61/286 (21%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	81/389 (21%)
		Lig_chan	533..807	CDD:278489	52/294 (18%)
GLR1.3	NP_199652.1	PBP1_GABAb_receptor	43..405	CDD:107361	65/306 (21%)
		ANF_receptor	57..385	CDD:279440	61/286 (21%)
		GluR_Plant	438..767	CDD:270404	80/389 (21%)
		Lig_chan	559..798	CDD:278489	52/290 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.910