DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ekar and GLR2.5

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_001332219.1	Gene:	GLR2.5 / 830991	AraportID:	AT5G11210	Length:	918	Species:	Arabidopsis thaliana

Alignment Length:	956	Identity:	205/956 - (21%)
Similarity:	356/956 - (37%)	Gaps:	202/956 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FLLFQFLSYGLGVPPL--VRIGAIFSNQPGMYNSELAFRYAIHRLNMDKSLLPETTVDYYVEYV- 68
            ||:|..||.|......  |::|.:..:     |..|| ..::..:||..|....|...:....|
plant    19 FLVFLVLSLGKSQKEALQVKVGIVLGS-----NVTLA-DLSLRAINMSLSEFYNTHNGFKTRIVL 77

  Fly    69 NRFDSFETV-------------QKVCKLIRVG--VQAVF---------SPTDSVLATHINSICDA 109
            |..||.:||             ::|..:|..|  :||.|         .|..|..||  :.:.|:
plant    78 NVRDSKQTVVGAAASALYLIKKREVVAIIGPGTSMQAPFLINLGNQSKVPIISFSAT--SPLLDS 140

  Fly   110 LDIPNIGRSAHDFSINVYPSKQLVNYAFNDVIQYLNWTR-FGILHEKENGIINLHQLSRSFHGEV 173
            |..|...|:.||.|..|        .|.:.:|:...|.. ..|..:.|.|...|..|..:|. |:
plant   141 LRSPYFIRATHDDSSQV--------QAISAIIESFRWREVVPIYVDNEFGEGILPNLVDAFQ-EI 196

  Fly   174 HMRQVSRDSYVSAL------NEFKGKEIHNIIIDTNSNGISILLKNILQQQMNEYKYHYLFTSFD 232
            ::    |..|.||:      ::.| ||::.::.......|..:|.::..:..:..|
plant   197 NV----RIRYRSAISLHYSDDQIK-KELYKLMTMPTRVFIVHMLPDLGSRLFSIAK--------- 247

  Fly   233 LETYDLEDFKYNFVNITSFRLVDTADVGVKQILKDIGLYSHH-------IFKKPYLNLHIKK--- 287
                :::.....:|.|.:..:.|     :..|:.:..|.:.|       .|.|....||::.
plant   248 ----EIDMLSKGYVWIVTNGIAD-----LMSIMGESSLVNMHGVLGVKTYFAKSKELLHLEARWQ 303

  Fly   288 ----STILESEPALMFDSVYVFAIGLQTLEQSHSLTLLNIS---CEEENSWD------------- 332
                ...|.:.....:|:....|:.::.:..      :|:|   .:|:.|.|
plant   304 KRFGGEELNNFACWAYDAATALAMSVEEIRH------VNMSFNTTKEDTSRDDIGTDLDELGVAL 362

  Fly   333 GGLSLINYLNAVEWKGLTGPIQFKDGQRVQFKLDLIKLKQHSIVKVGEWTPHGHLNITEPSMFFD 397
            .|..|::.|:.|.:||:.|..|.|:|:.......:|.:::.....||.|.....|   ..|:..|
plant   363 SGPKLLDALSTVSFKGVAGRFQLKNGKLEATTFKIINIEESGERTVGFWKSKVGL---VKSLRVD 424

  Fly   398 AGSMNVTLVVITILETPYVMMHYGKNFTGNER----------------------------FYGFC 434
            ..|.:...:...|.....:.:..|..|..|.:                            ..|||
plant   425 KVSHSSRRLRPIIWPGDTIFVPKGWEFPTNAKKLRIAVPKKDGFNNFVEVTKDENTNVPTVTGFC 489

  Fly   435 VDILETISRE----VGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTITYARE 495
            :|:..|:..:    |.::||....||.|      ..|.::.||..:...:.|.|||..||...|.
plant   490 IDVFNTVMSQMPYAVSYEYIPFDTPDGK------PRGSYDEMVYNVFLGEFDGAVGDTTILANRS 548

  Fly   496 SVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEW 560
            ..:||..|:...||..|..|...:....:.|:.||..|:|:....::..:.:.::|....:..|:
plant   549 HYVDFALPYSETGIVFLVPVKDGKEKGEWVFLKPLTKELWLVTAASFLYIGIMVWIFEYQADEEF 613

  Fly   561 KCINACDLENISIGNQFSLTDSFWFTIGT--FMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYT 623
            :       |.:.|.   .::..|:|:..|  |..:.|.   .:..||::...|.|..||:..|||
plant   614 R-------EQMIID---KISSVFYFSFSTLFFAHRRPS---ESFFTRVLVVVWCFVLLILTQSYT 665

  Fly   624 ANLAAFLTTERMINPIENAEDL-ASQTEISYGTLDSGSTMTF-------FRDSVIETYKKIWRSM 680
            |.|.:.||.:.:...:.:.:|| .|...|.|.|    .:.||       |.:|.::||
plant   666 ATLTSMLTVQELRPTVRHMDDLRKSGVNIGYQT----GSFTFERLKQMRFDESRLKTY------- 719

  Fly   681 DNKKPSAFTTTYEDGIKRVNQGNYAFLMESTMLDYIVQRDCN-LTQIGGLLDTKGYGIATPKGSP 744
              ..|......:..  |..|.|..|...|...:...:.:.|: .:.|.......|:|.|.|.|||
plant   720 --NSPEEMRELFLH--KSSNGGIDAAFDEVAYIKLFMAKYCSEYSIIEPTFKADGFGFAFPLGSP 780

  Fly   745 WRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIV 809
            ....||..||.:.|...::.:.:||:.. ::.|....||  .....|...|...:|:::....::
plant   781 LVSDISRQILNITEGDAMKAIENKWFLG-EKHCLDSTTS--DSPIQLDHHSFEALFLIVFVVSVI 842

  Fly   810 AAVVAFFEFWYNFRY--------NYEATPSQSVVNNKYN-QDGILE 846
            ..::......|..|.        |.:|..:|..||.:.| .|.|:|
plant   843 LLLLMLASRGYQERQHNASPNLPNDQANAAQEEVNEEGNVGDHIVE 888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	84/425 (20%)
		ANF_receptor	39..371	CDD:279440	79/393 (20%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	93/411 (23%)
		Lig_chan	533..807	CDD:278489	64/284 (23%)
GLR2.5	NP_001332219.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.910