DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ekar and GLUR2

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_001320141.1	Gene:	GLUR2 / 829682	AraportID:	AT4G35290	Length:	912	Species:	Arabidopsis thaliana

Alignment Length:	963	Identity:	221/963 - (22%)
Similarity:	368/963 - (38%)	Gaps:	223/963 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLIASGFLLFQFLSYGLGV-PPLVRIGAIFSNQPGMYNSE---LAFRYAIHRLNMDKSLLPETTV 61
            :||..|     .:|.|.|: |..|.:|||||  .|....|   :|.:.|...:|.|.|.|..:.:
plant    12 VLIGDG-----MISEGAGLRPRYVDVGAIFS--LGTLQGEVTNIAMKAAEEDVNSDPSFLGGSKL 69

  Fly    62 DYYVEYVNRFDSFETVQKVCKLIRVGVQAVFSPTDSVLATHINSICDALDIPNIGRSAHD----- 121
             ....|..:.:.|.|:....:.:.....|:..|..|::|..::.:.:.|.:|.:..:|.|
plant    70 -RITTYDAKRNGFLTIMGALQFMETDAVAIIGPQTSIMAHVLSHLANELSVPMLSFTALDPSLSA 133

  Fly   122 ----FSINVYPSKQLVNYAFNDVIQYLNWTRFGILHEKE----NGIINLHQLSRSFHGEVHMRQV 178
                |.:...||...:..|..::|.|..|:....|:..:    |||..|.........::..:.|
plant   134 LQFPFFVQTAPSDLFLMRAIAEMISYYGWSEVIALYNDDDNSRNGITALGDELEGRRCKISYKAV 198

  Fly   179 --------SRDSYVSALNEFKGKEIHNIIIDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLET 235
                    |....::.|.:.:|.|...||::|.......:.:...:..|.|..|.::.|::....
plant   199 LPLDVVITSPREIINELVKIQGMESRVIIVNTFPKTGKKIFEEAQKLGMMEKGYVWIATTWLTSL 263

  Fly   236 YD----------------------------LEDFKYNFVNITSFRLVDTADVGVKQILKDIGLYS 272
            .|                            .:||      :..:..:....||    |...|||:
plant   264 LDSVNPLPAKTAESLRGVLTLRIHTPNSKKKKDF------VARWNKLSNGTVG----LNVYGLYA 318

  Fly   273 HHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGLQTLEQSHSLTLLNISCEEE---NSWDGG 334
                                      :|:|::.|..::.|..|.:    |||...:   .|..||
plant   319 --------------------------YDTVWIIARAVKRLLDSRA----NISFSSDPKLTSMKGG 353

  Fly   335 LSL--------------INYLNAVEWKGLTGPIQF-KDGQRVQFKLDLIKLKQHSIVKVGEWTPH 384
            .||              ::|:......|:||.||| .|...:|...|:|.:......::|.|:.|
plant   354 GSLNLGALSIFDQGSQFLDYIVNTNMTGVTGQIQFLPDRSMIQPSYDIINVVDDGFRQIGYWSNH 418

  Fly   385 GHLNITEPSMFF----DAGSMNVTLVVIT----ILETP--YVMMHYG-------------KNFT- 425
            ..|:|..|...:    :..|.|..|..:|    ..|||  :|..:.|             |.|.
plant   419 SGLSIIPPESLYKKLSNRSSSNQHLNNVTWPGGTSETPRGWVFPNNGRRLRIGVPDRASFKEFVS 483

  Fly   426 ---GNERFYGFCVDILET----ISREVGFDYIL--DLVPDRKYGAKDPETGEW-NGMVAQLMKYK 480
               |:.:..|:.:|:.|.    ||..|..:::|  |       |.|:|...|: |.:...:.
plant   484 RLDGSNKVQGYAIDVFEAAVKLISYPVPHEFVLFGD-------GLKNPNFNEFVNNVTIGVF--- 538

  Fly   481 ADLAVGSMTITYARESVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLV 545
             |..||.:.|...|..::|||:|::..|:.::..|.....|. ::|:.|....:|. |..|:||
plant   539 -DAVVGDIAIVTKRTRIVDFTQPYIESGLVVVAPVTKLNDTP-WAFLRPFTPPMWA-VTAAFFL- 599

  Fly   546 SLCIYIVGKLSPIEWKCINACDLENISIGNQF------SLTDSFWFTIGTFMQQSPDIYPRAMST 604
                 |||.:..|         ||: .|.::|      .:....||:..|......:   ..:||
plant   600 -----IVGSVIWI---------LEH-RINDEFRGPPRKQIVTILWFSFSTMFFSHRE---NTVST 646

  Fly   605 --RIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRD 667
              |.:...|.|..|||.:||||:|.:.||.:::.:||...:.|.|          |...:.|...
plant   647 LGRAVLLIWLFVVLIITSSYTASLTSILTVQQLNSPIRGVDTLIS----------SSGRVGFQVG 701

  Fly   668 SVIETYK----KIWRS--MDNKKPSAFTTTYEDGIKRVNQGNYAFLMESTMLDYIVQRDCNLTQI 726
            |..|.|.    .|.||  :....|..:....::|...      |.:.|...:|..:...|.....
plant   702 SYAENYMIDELNIARSRLVPLGSPKEYAAALQNGTVA------AIVDERPYVDLFLSEFCGFAIR 760

  Fly   727 GGLLDTKGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTS-KQSKANS 790
            |......|:|.|.|:.||....:|.|||.|.|.|.:|.::|||...::  |:..|.| ....:..
plant   761 GQEFTRSGWGFAFPRDSPLAIDMSTAILGLSETGQLQKIHDKWLSRSN--CSNLNGSVSDEDSEQ 823

  Fly   791 LGLESIGGVFVVLIAGIIVAAVVAFF----EFWYNFRYNYEAT-PSQSVVNNK 838
            |.|.|..|:|:|......:|..:.||    :|:.:.:|:.||| ||.....:|
plant   824 LKLRSFWGLFLVCGISCFIALFIYFFKIVRDFFRHGKYDEEATVPSPESSRSK 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	84/433 (19%)
		ANF_receptor	39..371	CDD:279440	75/401 (19%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	105/412 (25%)
		Lig_chan	533..807	CDD:278489	76/288 (26%)
GLUR2	NP_001320141.1	PBP1_GABAb_receptor_plant	31..422	CDD:380645	84/433 (19%)
		GluR_Plant	466..804	CDD:270404	96/385 (25%)
		Lig_chan	590..840	CDD:395014	76/287 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	164	1.000	Inparanoid score	I1601
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.860