DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ekar and GLR2.7

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_180476.3	Gene:	GLR2.7 / 817460	AraportID:	AT2G29120	Length:	952	Species:	Arabidopsis thaliana

Alignment Length:	951	Identity:	212/951 - (22%)
Similarity:	345/951 - (36%)	Gaps:	239/951 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLIASGFLLFQFLSYGLGVPPLVRIGAIFSNQPGMYNSELAFRYAIHRLNMDKSLLPETTVD--- 62
            :|...||:|.:              |.:..||    .:|:.....:. |:...|.|..|:::
plant    18 VLFVCGFVLME--------------GCLGQNQ----TTEIKVGVVLD-LHTSFSKLCLTSINISL 63

  Fly    63 -----YYVEYVNRF-----DSFETVQKVCK----LIR-VGVQAVFSPTDSVLATHINSICDALDI 112
                 |:.:|..|.     ||.|.|.:...    ||: ..|.|:..|..|:.|..:..:.|...:
plant    64 SDFYKYHSDYTTRLAIHIRDSMEDVVQASSAALDLIKNEQVSAIIGPRTSMQAEFMIRLADKSQV 128

  Fly   113 PNIGRSAHDFSINVYPSKQLVNYAFND---------VIQYLNWTRFGILH---EKENGIINLHQL 165
            |.|..||....:....|...|....:|         :::...|.....::   |...||:.|
plant   129 PTITFSATCPLLTSINSPYFVRATLDDSSQVKAIAAIVKSFGWRNVVAIYVDNEFGEGILPL--- 190

  Fly   166 SRSFHGEVHMRQVSRDSYVSALNEFKGKEIHNIIIDTNSNGISIL--LKNILQQQMNEYKYHY-- 226
                             ...||.:.:...::..:|...:|...||  |..::..|...:..|.
plant   191 -----------------LTDALQDVQAFVVNRCLIPQEANDDQILKELYKLMTMQTRVFVVHMPP 238

  Fly   227 -LFTSFDLETYDLEDFKYNFVNITSFRLVDTADVGVKQILKD-------------IGLYSHHIFK 277
             |...|..:..::...:..:|    :.|.|    ||..:||.             :|:.||....
plant   239 TLGFRFFQKAREIGMMEEGYV----WLLTD----GVMNLLKSNERGSSLENMQGVLGVRSHIPKS 295

  Fly   278 KPYLNLHIKKSTILESEP--------AL-MFDSVYVFAI-----GLQTLEQSH---------SLT 319
            |...|..::...:...:.        || .:||:...|:     .:::|...|         :|.
plant   296 KKLKNFRLRWEKMFPKKGNDEEMNIFALRAYDSITALAMAVEKTNIKSLRYDHPIASGNNKTNLG 360

  Fly   320 LLNISCEEENSWDGGLSLINYLNAVEWKGLTGPIQFKDGQRVQFKLDLIKLKQHSIVKVGEWTP- 383
            .|.:|       ..|.||:..|:.|.:.||.|..:..:||......|:|.:.......:|.|.|
plant   361 TLGVS-------RYGPSLLKALSNVRFNGLAGEFELINGQLESSVFDVINIIGSEERIIGLWRPS 418

  Fly   384 HGHLNITEPSMFFDAGSMNVTLVVITIL------------------ETPYVMMHYG----KNFTG 426
            :|.:|         |.|.|.|.|:...|                  .|...|:..|    |.|.
plant   419 NGIVN---------AKSKNTTSVLGERLGPVIWPGKSKDVPKGWQIPTNGKMLRVGIPVKKGFL- 473

  Fly   427 NERFY--------------GFCVDILETISREVGFD----YILDLVPDRKYGAKDPETGEWNGMV 473
              .|.              |:|::|.|.:.:::.:.    ||..|.||..|          :.||
plant   474 --EFVDAKIDPISNAMTPTGYCIEIFEAVLKKLPYSVIPKYIAFLSPDENY----------DEMV 526

  Fly   474 AQLMKYKADLAVGSMTITYARESVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYV 538
            .|:.....|..||.:||...|...:|||.|:...|:|::  ||..:....:.|:.|.::::|:..
plant   527 YQVYTGAYDAVVGDVTIVANRSLYVDFTLPYTESGVSMM--VPLKDNKNTWVFLRPWSLDLWVTT 589

  Fly   539 LIAYFLVSLCIYIVGKLSPIEWKCINACDLENISIGNQF------SLTDSFWFTIGT--FMQQSP 595
            ...:..:...::|                ||: .:...|      .:..||||...|  |..:..
plant   590 ACFFVFIGFIVWI----------------LEH-RVNTDFRGPPHHQIGTSFWFAFSTMNFAHREK 637

  Fly   596 DIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLAS-QTEISYGTLDSG 659
            .:...|   |.:...|.|..|:::.||||||.:|.|.:.:...:.|.:||.. ...|.|
plant   638 VVSNLA---RFVVLVWCFVVLVLIQSYTANLTSFFTVKLLQPTVTNWKDLIKFNKNIGY------ 693

  Fly   660 STMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYEDGIKRVNQGNYAFLMESTMLDYIV-QRDCNL 723
            ...||.|    |..|.  :..|..:...|.:..|......|....|...|...:..|: |.....
plant   694 QRGTFVR----ELLKS--QGFDESQLKPFGSAVECDELFSNGTITASFDEVAYIKVILSQNSSKY 752

  Fly   724 TQIGGLLDTKGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKA 788
            |.:.....|.|:|...||.||..|.:|.|||.:.:..::|.:.:||:|..: .|...|||..|
plant   753 TMVEPSFKTAGFGFVFPKKSPLTDDVSRAILNVTQGEEMQHIENKWFKKPN-NCPDLNTSLSS-- 814

  Fly   789 NSLGLESIGGVFVVLIAGIIVAAVVAFFEFWYNFRYNYEAT 829
            |.|.|.|..|:|  |||||  |:.:|...|..||.|.::.|
plant   815 NHLSLSSFWGLF--LIAGI--ASFLALLIFVANFLYEHKHT 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	84/435 (19%)
		ANF_receptor	39..371	CDD:279440	77/402 (19%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	97/418 (23%)
		Lig_chan	533..807	CDD:278489	73/283 (26%)
GLR2.7	NP_180476.3	PBP1_GABAb_receptor	40..421	CDD:107361	79/416 (19%)
		ANF_receptor	54..405	CDD:279440	74/385 (19%)
		GluR_Plant	460..799	CDD:270404	91/385 (24%)
		Lig_chan	584..832	CDD:278489	75/286 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.910