DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ekar and GLR2.8

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_001324459.1	Gene:	GLR2.8 / 817459	AraportID:	AT2G29110	Length:	948	Species:	Arabidopsis thaliana

Alignment Length:	998	Identity:	210/998 - (21%)
Similarity:	374/998 - (37%)	Gaps:	217/998 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LFQFLSYGLGVPPL--VRIGAIFSNQPGMYNSELAFRYAIHRLNMDKSLLPETTV-----DYYVE 66
            ||..|..|||...:  :::|.:..                  ||...|.:..|::     |:|.:
plant    18 LFLLLEVGLGQNQISEIKVGVVLD------------------LNTTFSKICLTSINLALSDFYKD 64

  Fly    67 YVN---------RFDSFETVQKVCKLIRV----GVQAVFSPTDSVLATHINSICDALDIPNIGRS 118
            :.|         |....:|||.....:.:    .|.|:..|.||:.|..:..:.:...:|.|..|
plant    65 HPNYRTRLALHVRDSMKDTVQASAAALDLIQNEQVSAIIGPIDSMQAKFMIKLANKTQVPTISFS 129

  Fly   119 AHDFSINVYPSKQLVNYAFND---------VIQYLNWTRFGILH---EKENGI-------INLHQ 164
            |....:....|...|....:|         :.:...|.....::   |...||       :...|
plant   130 ATSPLLTSIKSDYFVRGTIDDSYQVKAIAAIFESFGWRSVVAIYVDNELGEGIMPYLFDALQDVQ 194

  Fly   165 LSRSFHGEVHMRQVSRDSYVSALNEFKGKEIHNIIIDTNSNGISILLKNILQQQMNEYKYHYLFT 229
            :.||    |...:.:.|..:..|.:...::....::...|...|.:.:...:..|.|..|.:|.|
plant   195 VDRS----VIPSEANDDQILKELYKLMTRQTRVFVVHMASRLASRIFEKATEIGMMEEGYVWLMT 255

  Fly   230 SFDLETYDLEDFKYNFVNITSFRLVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESE 294
            :         ...:...:|...|.::|.| ||      :|:.||....|...:..::.....:.|
plant   256 N---------GMTHMMRHIHHGRSLNTID-GV------LGVRSHVPKSKGLEDFRLRWKRNFKKE 304

  Fly   295 PALMFDSVYVFAIGLQTLEQSHSLTL----LNISCEEENSWDG----------------GLSLIN 339
            ...:.|.:.:|  ||...:.:.:|.:    .|||....|:..|                |.||:.
plant   305 NPWLRDDLSIF--GLWAYDSTTALAMAVEKTNISSFPYNNASGSSNNMTDLGTLHVSRYGPSLLE 367

  Fly   340 YLNAVEWKGLTGPIQFKDGQRVQFKLDLIKLKQHSIVKVGEWTP-HGHLNITEPSMFFDAGSMNV 403
            .|:.:.:.||.|.....|.|....|.::|....:....||.||| :|.:|:.........|....
plant   368 ALSEIRFNGLAGRFNLIDRQLESPKFEIINFVGNEERIVGFWTPSNGLVNVNSNKTTSFTGERFG 432

  Fly   404 TLV---VITILETPYVMMHYGK-------------NF--------TGNERFYGFCVDILETISRE 444
            .|:   ..||:...:.:...||             ||        |......|:.:||.|...::
plant   433 PLIWPGKSTIVPKGWEIPTNGKKIKVGVPVKKGFFNFVEVITDPITNITTPKGYAIDIFEAALKK 497

  Fly   445 VGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTITYARESVIDFTKPFMNLGI 509
            :.:..|     .:.|..:.|: .:::.:|.::.....|..||.:|||..|....|||.|:...|:
plant   498 LPYSVI-----PQYYRFESPD-DDYDDLVYKVDNGTLDAVVGDVTITAYRSLYADFTLPYTESGV 556

  Fly   510 SILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEWKCINACDLENISIG 574
            |::..|..:|....:.|:.|..:::|:.....:.|:...:::                .|: .:.
plant   557 SMMVPVRDNENKNTWVFLKPWGLDLWVTTACFFVLIGFVVWL----------------FEH-RVN 604

  Fly   575 NQF------SLTDSFWFTIGTFMQQSPDIYPRAMS--TRIISSTWGFFSLIIVASYTANLAAFLT 631
            ..|      .:..||||:..|.:....:   :.:|  .|.:...|.|..|::..||||||.:|||
plant   605 TDFRGPPHHQIGTSFWFSFSTMVFAHRE---KVVSNLARFVVVVWCFVVLVLTQSYTANLTSFLT 666

  Fly   632 TERMINPIENAEDLASQTEISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYEDGI 696
            .:|......|.:||....:  |.....|:   |.:|.:|:      ...:..|...|.::.|...
plant   667 VQRFQPAAINVKDLIKNGD--YVGYQHGA---FVKDFLIK------EGFNVSKLKPFGSSEECHA 720

  Fly   697 KRVNQGNYAFLMESTMLDYIVQRDCN-LTQIGGLLDTKGYGIATPKGSPWRDKISLAILELQERG 760
            ...|....|...|...|..|:.:.|: ...:.....|.|:|.|.|:.||....:|.|||.:.:..
plant   721 LLSNGSISAAFDEVAYLRAILSQYCSKYAIVEPTFKTAGFGFAFPRNSPLTGDVSKAILNVTQGD 785

  Fly   761 DIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGI--IVAAVVAFFEFWYNFR 823
            ::|.:.:||:...:: |....|:..|  |.|.|.|..|:|  |||||  .:|.::..|.|.|..|
plant   786 EMQHIENKWFMKQND-CPDPKTALSS--NRLSLRSFWGLF--LIAGIASFLALLIFVFLFLYENR 845

  Fly   824 Y-------------------NYEA------TPSQSVVNN------KY--NQDGILESERNYTP-P 854
            :                   |::.      |...|.|::      :|  :...:..:.|.::| .
plant   846 HTLCDDSEDSIWRKLTSLFRNFDEKDIKSHTFKSSAVHHVSSPMTQYIPSPSTLQIAPRPHSPSQ 910

  Fly   855 DRSFWIEIAEELRYASWCMNKQK 877
            ||:|      |||..|:..|:::
plant   911 DRAF------ELRRVSFTPNEER 927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	80/421 (19%)
		ANF_receptor	39..371	CDD:279440	73/388 (19%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	88/401 (22%)
		Lig_chan	533..807	CDD:278489	67/282 (24%)
GLR2.8	NP_001324459.1	PBP1_GABAb_receptor_plant	35..419	CDD:380645	81/423 (19%)
GLR2.8	NP_001324459.1	GluR_Plant	454..795	CDD:270404	83/377 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.910