DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ekar and GLR2.9

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_001325277.1	Gene:	GLR2.9 / 817458	AraportID:	AT2G29100	Length:	942	Species:	Arabidopsis thaliana

Alignment Length:	1013	Identity:	215/1013 - (21%)
Similarity:	372/1013 - (36%)	Gaps:	249/1013 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GFLLFQFLSYGLGVPPL--VRIGAIFSNQPGMYNSELAFRYAIHRLNMDKSLLPETTV-----DY 63
            ||||   :..|||....  :::|.:..                  ||...|.:..|::     |:
plant    16 GFLL---MGVGLGQNQTSEIKVGVVLD------------------LNTTFSKICLTSIKMAVSDF 59

  Fly    64 YVEYVNRF--------DSFE-TVQ---KVCKLIRV-GVQAVFSPTDSVLATHINSICDALDIPNI 115
            |.::.|..        ||.| |||   ....||:. .|.|:..|.:|:.|..:..:.:...:|.|
plant    60 YADHPNYLTRLTLHVRDSMEDTVQASAAALDLIKTEQVSAIIGPINSMQADFMIKLANKTQVPTI 124

  Fly   116 GRSAHDFSINVYPSKQLVNYAFND---------VIQYLNWTRFGILHEKENGIINLHQLSRSFHG 171
            ..||....:....|...|....:|         :.::..|.|...::           :...| |
plant   125 TFSATSPLLTSIKSPYFVRATIDDSSQVRAIASIFKFFRWRRVVAIY-----------VDNEF-G 177

  Fly   172 EVHMRQVSRDSYVSALNEFKGKEIHNIII--DTNSNGISILLKNILQQQMNEYKYHYLFTSFDLE 234
            |..|     .....||.:.   |:...:|  :...:.|...|:.::::|...:..| :.:|..|.
plant   178 EGFM-----PFLFDALQDV---EVKRSVIPPEAIDDEIQKELRKLMERQARVFVVH-MESSLALR 233

  Fly   235 TYDL--------EDFKYNFVN--------ITSFRLVDTADVGVKQILKDIGLYSHHIFKKPYLNL 283
            .:.:        |.:.:...|        |.:.|.::|.: ||      :|:.||....|...:.
plant   234 VFQIARDIGMMEEGYVWLMTNGMTHMMRHINNGRSLNTIE-GV------LGVRSHVPKSKELGDF 291

  Fly   284 HIKKSTILESEPALMFDSVYVFAIGLQTLEQSHSLTLLNISCEEENS----WDGGL--------- 335
            .::.....|.|...|.|.:.|||     |....|:|.|..:.|:.|:    :|.|.
plant   292 RLRWKRTFEKENPSMRDDLNVFA-----LWAYDSITALAKAVEKANTKSLWYDNGSTLSKNRTDL 351

  Fly   336 ----------SLINYLNAVEWKGLTGPIQFKDGQRVQFKLDLIKLKQHSIVKVGEWTPH-GHLNI 389
                      ||....:.|.:.||.|..:..|||....|.::|....:....:|.|||. |.::.
plant   352 GNVGVSLYGPSLQKAFSEVRFNGLAGEFKLIDGQLQSPKFEIINFVGNEERIIGFWTPRDGLMDA 416

  Fly   390 TEPSM-----------------------------------FFDAGSMNVTLVVITILETPYVMMH 419
            |..:.                                   |||  .:.||:..||..:||
plant   417 TSSNKKTLGPVIWPGKSKIVPKGWEIPGKKLRVGVPMKKGFFD--FVKVTINPITNKKTP----- 474

  Fly   420 YGKNFTGNERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLA 484
                       .|:.::|.|...:|:.:     ||.......:.|  ..:|.:|.|:.....|..
plant   475 -----------TGYAIEIFEAALKELPY-----LVIPEYVSFESP--NNYNNLVYQVYDKTWDAV 521

  Fly   485 VGSMTITYARESVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCI 549
            ||.:|||..|....|||.||...|:|::..|..:|....:.|:.|.::|:|:.....:..:...:
plant   522 VGDITITANRSLYADFTLPFTESGVSMMVPVRDNENKDTWVFLEPWSLELWVTTGCFFVFIGFVV 586

  Fly   550 YIVGKLSPIEWKCINACDLENISIGNQFSLTDSFWFTIGT--FMQQSPDIYPRAMSTRIISSTWG 612
            ::      .|.: :|. |...   ..|:.:..|.||:..|  |..:...:...|   |.:...|.
plant   587 WL------FEHR-VNT-DFRG---PPQYQIGTSLWFSFSTMVFAHRENVVSNLA---RFVVVVWC 637

  Fly   613 FFSLIIVASYTANLAAFLTTERMINPIENAEDLASQTE-ISYGTLDSGSTMTFFRDSVIETYKKI 676
            |..|::..||||:|.:|||.:.:...:.|..||....: :.|   ..|:   |.:|.::    .:
plant   638 FVVLVLTQSYTASLTSFLTVQSLQPTVTNVNDLIKNRDCVGY---QGGA---FVKDILL----GL 692

  Fly   677 WRSMDNKKPSAFTTTYEDGI-KRVNQGNYAFLMESTMLDYIVQRDCN-LTQIGGLLDTKGYGIAT 739
            ....|..||.......:|.: |..::|..|...|...|..|:.:.|: ...:.....|.|:|.|.
plant   693 GFHEDQLKPFDSAKDADDLLSKGKSKGIAAAFDEVAYLKAILSQSCSKYVMVEPTFKTGGFGFAF 757

  Fly   740 PKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLI 804
            ||.||...:.|.|||.|.:....|.:.|:|:...:: |....|:..|  |.|.|.|..|:|  ||
plant   758 PKNSPLTGEFSRAILNLTQNNVTQQIEDRWFPKKND-CPDPMTALSS--NRLNLSSFLGLF--LI 817

  Fly   805 AGIIVA----AVVAFF--------------EFWYNFRYNYEATPSQSVVNNKYNQDGI--LESER 849
            ||..::    ..||.|              ..|...::.::....:.:.::.:....|  :.|..
plant   818 AGTAISFSLLVFVALFLYEHRHTLGDDSEDSLWRKLKFLFKIFDEKDMNSHTFKNSAIHNISSPM 882

  Fly   850 NYTPPDRSF-----WIEIAE-----ELRYASWCMNKQK 877
            .:..|..|.     |.:...     |||..|:..::::
plant   883 THKTPSPSTVQITPWPQSPSQNREFELRRVSFSPSEER 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	86/432 (20%)
		ANF_receptor	39..371	CDD:279440	80/399 (20%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	92/373 (25%)
		Lig_chan	533..807	CDD:278489	70/278 (25%)
GLR2.9	NP_001325277.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.910