DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ekar and GLR2.2

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_180048.1	Gene:	GLR2.2 / 817008	AraportID:	AT2G24720	Length:	920	Species:	Arabidopsis thaliana

Alignment Length:	841	Identity:	179/841 - (21%)
Similarity:	331/841 - (39%)	Gaps:	190/841 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 VQAVFSPTDSVLATHINSICDALDIPNIG-----------RSAHDFSINVYPSKQLVNYAFNDVI 141
            |:|:..|..|:.|..:..|.....:|.:.           ||.:.|......|.|:  :|...:|
plant    97 VKAILGPWTSMQAHFLIEIGQKSRVPVVSYSATSPSLTSLRSPYFFRATYEDSSQV--HAIKAII 159

  Fly   142 QYLNWTRFGILHEKENGIINLHQLSRSFHGEVHMRQVSRDSYVSALNEFKGKEIHNIIIDTNS-- 204
            :...|..          ::.:: :..:| ||..|.:::     .:|.:...:..:..:|..|:
plant   160 KLFGWRE----------VVPVY-IDNTF-GEGIMPRLT-----DSLQDINVRIPYRSVIPLNATD 207

  Fly   205 NGISILLKNILQQQMNEYKYHY---LFTSFDLETYDLEDFKYNFVNITSFRLVD----------- 255
            ..||:.|..::......:..|.   |.::..::..:|...|..:|.|.:..::|
plant   208 QDISVELLKMMNMPTRVFIVHMSSSLASTVFIKAKELGLMKPGYVWILTNGVMDGLRSINETGIE 272

  Fly   256 --TADVGVKQIL---KDIGLYSHHIFKK-PYLNLHIKKSTILESEPALMFDSVYVFAIGLQTLEQ 314
              ...:|:|..:   ||:..:.....:: |.:.|::......::..||   ::.:...|:..:..
plant   273 AMEGVLGIKTYIPKSKDLETFRSRWKRRFPQMELNVYGLWAYDATTAL---AMAIEDAGINNMTF 334

  Fly   315 SHSLTLLNISCEEENSWDG-GLS-----LINYLNAVEWKGLTGPIQFKDGQRVQFKLDLIKLKQH 373
            |:..|..|:|     ..|| |||     |:..::.|::|||.|...|..||......:::.:...
plant   335 SNVDTGKNVS-----ELDGLGLSQFGPKLLQTVSTVQFKGLAGDFHFVSGQLQPSVFEIVNMIGT 394

  Fly   374 SIVKVGEWT--------------------------------------PHG--------HLNITEP 392
            ....:|.||                                      |.|        .|.|..|
plant   395 GERSIGFWTEGNGLVKKLDQEPRSIGTLSTWPDHLKHIIWPGEAVSVPKGWEIPTNGKKLRIGVP 459

  Fly   393 SM--FFDAGSMNVTLVVITILETPYVMMHYGKNFTGNERFYGFCVDILETISREVGFDYILDLVP 455
            ..  |.|         ::.:...|         .|.:....|||:|..|.:.:.:.:|...:..|
plant   460 KRIGFTD---------LVKVTRDP---------ITNSTVVKGFCIDFFEAVIQAMPYDVSYEFFP 506

  Fly   456 DRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTITYARESVIDFTKPFMNLGISILFKVPTSEP 520
            ..|...:  ..|..|.:|.|:...:.|..||..||...|.|.:|||.|||..|:.::  ||..:.
plant   507 FEKPNGE--PAGNHNDLVHQVYLGQFDAVVGDTTILANRSSFVDFTLPFMKSGVGLI--VPLKDE 567

  Fly   521 TR--LFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEWKCINACDLENISIGNQFSLTDSF 583
            .:  .|||:.||:||:|:..|:.:|||.:.::      .:|.: :|: |....:   .:..:..|
plant   568 VKRDKFSFLKPLSIELWLTTLVFFFLVGISVW------TLEHR-VNS-DFRGPA---NYQASTIF 621

  Fly   584 WFTIGTFMQQSPDIYPR----AMSTRIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAED 644
            ||...|.:     ..||    :...|.:..||.|..|::..||||:||:.||::: :||     .
plant   622 WFAFSTMV-----FAPRERVLSFGARSLVVTWYFVLLVLTQSYTASLASLLTSQQ-LNP-----T 675

  Fly   645 LASQTEISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSA----FTTTYE--DGIKR--VNQ 701
            :.|.:.:    |..|.|:.:.|.|.|     :.:..:...|.:    |.|..|  :.:|:  .|.
plant   676 ITSMSSL----LHRGETVGYQRTSFI-----LGKLNETGFPQSSLVPFDTAEECDELLKKGPKNG 731

  Fly   702 GNYAFLMESTMLDYIVQRDCN-LTQIGGLLDTKGYGIATPKGSPWRDKISLAILELQERGDIQML 765
            |..|..:.:..:...:.:.|| ...:....:..|:|...|.|||....:|.|||::.|......|
plant   732 GVAAAFLGTPYVRLFLGQYCNTYKMVEEPFNVDGFGFVFPIGSPLVADVSRAILKVAESPKAVEL 796

  Fly   766 YDKWWKNTDETC----TRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFEFWYNF 822
            ...|:|..:::|    |..:::....|..||:.|...:|:|    :.|..|:|..:|.:.|
plant   797 EHAWFKKKEQSCPDPVTNPDSNPTVTAIQLGVGSFWFLFLV----VFVVCVLALGKFTFCF 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	64/384 (17%)
		ANF_receptor	39..371	CDD:279440	59/321 (18%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	96/383 (25%)
		Lig_chan	533..807	CDD:278489	69/290 (24%)
GLR2.2	NP_180048.1	PBP1_GABAb_receptor	33..412	CDD:107361	62/341 (18%)
		ANF_receptor	47..392	CDD:279440	59/321 (18%)
		HisJ	438..>587	CDD:223904	45/170 (26%)
		GluR_Plant	452..801	CDD:270404	100/401 (25%)
		Lig_chan	582..819	CDD:278489	63/267 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.910