DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ekar and gria1a

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_991161.1	Gene:	gria1a / 798689	ZFINID:	ZDB-GENE-020125-1	Length:	914	Species:	Danio rerio

Alignment Length:	881	Identity:	320/881 - (36%)
Similarity:	483/881 - (54%)	Gaps:	94/881 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LIASGFLLFQFLSYGLGVPPLVRIGAIFSNQPGMYNSELAFRYAI-HRLNMDKSLLPETTVDYYV 65
            |:.:.||   .|.:|...|..:.||.:|..:...|.   .||:|: |..::.| |:|:      |
Zfish     7 LLCTSFL---GLCFGSSFPSNINIGGLFPTESHEYE---VFRFALSHHQDIPK-LVPQ------V 58

  Fly    66 EYVNRFDSFETVQKVCKLIRVGVQAVFSPTDSVLATHINSICDALDI----PNIG-RSAHDFSIN 125
            :.|...:||......|.....||.|:....|......:.|.|.||.:    |:.. .:::.|.|.
Zfish    59 DMVKLGNSFSMTYAFCSQFSKGVYAIIGVYDRKTVNMLMSFCGALHVCFVTPSFPMENSNQFVIQ 123

  Fly   126 VYPSKQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQL--SRSFHG----EVHMRQVSRDSYV 184
            :.|..|   .|...||::..|::|..::..::|:..|.::  :.:.|.    .|::..::..|::
Zfish   124 LRPELQ---DALVGVIEHYRWSKFVYMYSSDSGLSVLQKVLDTAAEHNWLVTSVNVETMTEASFL 185

  Fly   185 SALNEFKGKEIHNIIIDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETYDLEDFKYNFVNIT 249
            ....:...|:...||||.....::.:||.|::...|...|||:..:......||.:||....|:|
Zfish   186 KVFQDLDKKKEGQIIIDCELERLTSILKKIIELGKNVKSYHYILANLGFLDIDLTEFKKGEANVT 250

  Fly   250 SFRLVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGLQTLEQ 314
            .|:||:.||..|.:.::....:.:...|.|      |:.  |:...||.:|.|.|.:...|.|.:
Zfish   251 GFQLVNYADPNVSRTVQQWMEFDNKDAKVP------KRR--LKYTGALTYDGVKVMSTAFQNLRR 307

  Fly   315 SHSLTLLNIS---------CEEENSWDGGLSLINYLNAVEWKGLTGPIQFKD-GQRVQFKLDLIK 369
            ..    ::||         ......|..|:.:...|..|..:||||.|||.: |:|..:.:.:::
Zfish   308 QR----IDISRRGNAGECLANPPAPWGQGIDIQRALQQVRIEGLTGHIQFNEKGRRTNYSISVME 368

  Fly   370 LKQHSIVKVGEWTPHGHLNITE---PSMFFDAGSMNVTLVVITILETPYVMMHYG-KNFTGNERF 430
            |:.....|||.|........|.   |......|..|.|.:|.||||:||||:... ::||||:::
Zfish   369 LRPTGPKKVGYWNEDEKFVSTAAYMPGSNETYGLQNRTYIVTTILESPYVMLKKNHEHFTGNDKY 433

  Fly   431 YGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTITYARE 495
            .|:||::...|::.||:.|||.:|.|.||||:|.||..|||||.:|:..|||:||..:|||..||
Zfish   434 EGYCVELAAEIAKHVGYHYILKIVADGKYGARDAETMMWNGMVGELVYGKADVAVAPLTITLVRE 498

  Fly   496 SVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEW 560
            .||||:||||:|||||:.|.||.....:|||::|||.|||:.::.||..||:.:::|.:.||.||
Zfish   499 EVIDFSKPFMSLGISIMIKKPTKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEW 563

  Fly   561 KCINACDLENISIG------------------------------NQFSLTDSFWFTIGTFMQQSP 595
               :|.|.|:   |                              |:|.:.:|.||::|.||||..
Zfish   564 ---HADDCED---GAEENPNQPSSSSAQPGQNQQNQNQQSQEQTNEFGIFNSLWFSLGAFMQQGC 622

  Fly   596 DIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGS 660
            ||.||::|.||:...|.||:|||::|||||||||||.|||::|||:|||||.||||:|||||:||
Zfish   623 DISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDAGS 687

  Fly   661 TMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYEDGIKRV--NQGNYAFLMESTMLDYIVQR-DCN 722
            |..|||.|.|..::|:|..|.:..||.|..|.::|:.||  ::|.||:|:||||.:||.|| .|:
Zfish   688 TKEFFRRSKIAVFEKMWSYMKSADPSVFVKTTDEGVMRVRKSKGKYAYLLESTMNEYIEQRKPCD 752

  Fly   723 LTQIGGLLDTKGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSK 787
            ..::||.||:||||||||||||.|:.::||:|:|.|:|.:..|.:|||.:..| |.......:.|
Zfish   753 TMKVGGNLDSKGYGIATPKGSPLRNPVNLAVLKLNEQGLLDKLKNKWWYDKGE-CGSGGGDSKDK 816

  Fly   788 ANSLGLESIGGVFVVLIAGIIVAAVVAFFEFWYNFR 823
            .::|.|.::.|||.:||.|:.:|.:||..||.|..|
Zfish   817 TSALSLSNVAGVFYILIGGLGLAMLVALVEFCYKSR 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	94/385 (24%)
		ANF_receptor	39..371	CDD:279440	85/353 (24%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	198/402 (49%)
		Lig_chan	533..807	CDD:278489	138/306 (45%)
gria1a	NP_991161.1	Periplasmic_Binding_Protein_Type_1	26..387	CDD:299141	94/385 (24%)
		ANF_receptor	36..369	CDD:279440	86/357 (24%)
		PBP2_iGluR_AMPA_GluR1	404..806	CDD:270447	200/408 (49%)
		Lig_chan	536..836	CDD:278489	138/306 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591502
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.640