Protein Alignment Ekar and gria1a

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_991161.1
• Gene: gria1a / 798689
• ZFINID: ZDB-GENE-020125-1
• Length: 914
• Species: Danio rerio
• Alignment Length: 881
• Identity: 320/881 - (36%)
• Similarity: 483/881 - (54%)
• Gaps: 94/881 - (10%)

  Fly     2 LIASGFLLFQFLSYGLGVPPLVRIGAIFSNQPGMYNSELAFRYAI-HRLNMDKSLLPETTVDYYV 65
            |:.:.||   .|.:|...|..:.||.:|..:...|.   .||:|: |..::.| |:|:      |
Zfish     7 LLCTSFL---GLCFGSSFPSNINIGGLFPTESHEYE---VFRFALSHHQDIPK-LVPQ------V 58

  Fly    66 EYVNRFDSFETVQKVCKLIRVGVQAVFSPTDSVLATHINSICDALDI----PNIG-RSAHDFSIN 125
            :.|...:||......|.....||.|:....|......:.|.|.||.:    |:.. .:::.|.|.
Zfish    59 DMVKLGNSFSMTYAFCSQFSKGVYAIIGVYDRKTVNMLMSFCGALHVCFVTPSFPMENSNQFVIQ 123

  Fly   126 VYPSKQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQL--SRSFHG----EVHMRQVSRDSYV 184
            :.|..|   .|...||::..|::|..::..::|:..|.::  :.:.|.    .|::..::..|::
Zfish   124 LRPELQ---DALVGVIEHYRWSKFVYMYSSDSGLSVLQKVLDTAAEHNWLVTSVNVETMTEASFL 185

  Fly   185 SALNEFKGKEIHNIIIDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETYDLEDFKYNFVNIT 249
            ....:...|:...||||.....::.:||.|::...|...|||:..:......||.:||....|:|
Zfish   186 KVFQDLDKKKEGQIIIDCELERLTSILKKIIELGKNVKSYHYILANLGFLDIDLTEFKKGEANVT 250

  Fly   250 SFRLVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGLQTLEQ 314
            .|:||:.||..|.:.::....:.:...|.|      |:.  |:...||.:|.|.|.:...|.|.:
Zfish   251 GFQLVNYADPNVSRTVQQWMEFDNKDAKVP------KRR--LKYTGALTYDGVKVMSTAFQNLRR 307

  Fly   315 SHSLTLLNIS---------CEEENSWDGGLSLINYLNAVEWKGLTGPIQFKD-GQRVQFKLDLIK 369
            ..    ::||         ......|..|:.:...|..|..:||||.|||.: |:|..:.:.:::
Zfish   308 QR----IDISRRGNAGECLANPPAPWGQGIDIQRALQQVRIEGLTGHIQFNEKGRRTNYSISVME 368

  Fly   370 LKQHSIVKVGEWTPHGHLNITE---PSMFFDAGSMNVTLVVITILETPYVMMHYG-KNFTGNERF 430
            |:.....|||.|........|.   |......|..|.|.:|.||||:||||:... ::||||:::
Zfish   369 LRPTGPKKVGYWNEDEKFVSTAAYMPGSNETYGLQNRTYIVTTILESPYVMLKKNHEHFTGNDKY 433

  Fly   431 YGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTITYARE 495
            .|:||::...|::.||:.|||.:|.|.||||:|.||..|||||.:|:..|||:||..:|||..||
Zfish   434 EGYCVELAAEIAKHVGYHYILKIVADGKYGARDAETMMWNGMVGELVYGKADVAVAPLTITLVRE 498

  Fly   496 SVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEW 560
            .||||:||||:|||||:.|.||.....:|||::|||.|||:.::.||..||:.:::|.:.||.||
Zfish   499 EVIDFSKPFMSLGISIMIKKPTKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEW 563

  Fly   561 KCINACDLENISIG------------------------------NQFSLTDSFWFTIGTFMQQSP 595
               :|.|.|:   |                              |:|.:.:|.||::|.||||..
Zfish   564 ---HADDCED---GAEENPNQPSSSSAQPGQNQQNQNQQSQEQTNEFGIFNSLWFSLGAFMQQGC 622

  Fly   596 DIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGS 660
            ||.||::|.||:...|.||:|||::|||||||||||.|||::|||:|||||.||||:|||||:||
Zfish   623 DISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDAGS 687

  Fly   661 TMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYEDGIKRV--NQGNYAFLMESTMLDYIVQR-DCN 722
            |..|||.|.|..::|:|..|.:..||.|..|.::|:.||  ::|.||:|:||||.:||.|| .|:
Zfish   688 TKEFFRRSKIAVFEKMWSYMKSADPSVFVKTTDEGVMRVRKSKGKYAYLLESTMNEYIEQRKPCD 752

  Fly   723 LTQIGGLLDTKGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSK 787
            ..::||.||:||||||||||||.|:.::||:|:|.|:|.:..|.:|||.:..| |.......:.|
Zfish   753 TMKVGGNLDSKGYGIATPKGSPLRNPVNLAVLKLNEQGLLDKLKNKWWYDKGE-CGSGGGDSKDK 816

  Fly   788 ANSLGLESIGGVFVVLIAGIIVAAVVAFFEFWYNFR 823
            .::|.|.::.|||.:||.|:.:|.:||..||.|..|
Zfish   817 TSALSLSNVAGVFYILIGGLGLAMLVALVEFCYKSR 852

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	94/387 (24%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	198/402 (49%)
		Lig_chan	532..806	CDD:459656	138/306 (45%)
gria1a	NP_991161.1	Periplasmic_Binding_Protein_type1	26..390	CDD:471960	94/388 (24%)
		PBP2_iGluR_AMPA_GluR1	404..806	CDD:270447	200/408 (49%)
		Lig_chan	536..835	CDD:459656	138/305 (45%)