DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ekar and grik1a

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	XP_009303592.1	Gene:	grik1a / 798001	ZFINID:	ZDB-GENE-030131-6502	Length:	919	Species:	Danio rerio

Alignment Length:	858	Identity:	342/858 - (39%)
Similarity:	520/858 - (60%)	Gaps:	55/858 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FLLFQFLSYGLGVPPLVRIGAIF---SNQPGMYNSELAFRYAIHRLNMDKSLLPETTVDYYVEYV 68
            |..:....:.|....::|||.||   .|:| :...||||::|:..:|.:::|:|.||:.|.::.|
Zfish    23 FFFYSMAKFYLSEQQVIRIGGIFETRENEP-VSMDELAFKFAVTSINRNRTLMPNTTLTYDIQRV 86

  Fly    69 NRFDSFETVQKVCKLIRVGVQAVFSPTDSVLATHINSICDALDIPNI-GRSAH-------DFSIN 125
            |.|||||..::||..:.:||.|||.|:.|...:.:.|||:||::|:| .|..|       :|.||
Zfish    87 NLFDSFEASRRVCDQLALGVAAVFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNKDNFYIN 151

  Fly   126 VYPSKQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQLSRS---FHGEVHMRQVSRDSYVS-- 185
            :||....::.|..|::.:..|....:::|...|::.:.:|.::   .:.::.:||:......|
Zfish   152 LYPEYTSISRAILDIVIFYKWKCVTVVYEDSTGLMRMQELIKAPSKNNLKIRIRQLPSGGGDSRP 216

  Fly   186 ALNEFKGKEIHNIIIDTNSNGISILLKNILQQ-QMNEYKYHYLFTSFDLETYDLEDFKYNFVNIT 249
            .|.|.|.::...:|.|.:....:.|||.::.. .|.|| ||:.||:.||...|||.::|:.||:|
Zfish   217 LLKEMKKEKEFYVIFDCSYQVAAELLKQLMSMGMMTEY-YHFFFTTLDLFALDLEPYRYSGVNMT 280

  Fly   250 SFRLVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGLQTLEQ 314
            :|||::..|..|..:::...:.......||...|   .|.|:.:..|||:|:|::.|:..|...|
Zfish   281 AFRLLNLDDSYVASVIQKWSMERQLAPPKPESGL---MSGIMTTAAALMYDAVFMVAVASQRATQ 342

  Fly   315 SHSLTLLNISCEEENSWDGGLSLINYLNAVEWKGLTGPIQFK--DGQRVQFKLDLIKLKQHSI-- 375
               :|:.::.|.....|..|...:|.....:|.||||.|...  ||.|.:|.||||.||:...
Zfish   343 ---MTVSSLQCHRHKPWRYGPRFMNLFKEAQWDGLTGRIVLNKTDGLRKEFNLDLISLKEDGTAK 404

  Fly   376 -------------VKVGEWTPHGHLNITE--PSMFFDAGSMNVTLVVITILETPYVMMHYGKN-- 423
                         .|:|.|..:..||:||  .:........|.||:|.||||.||||  |.|:
Zfish   405 RVADGASRPNKLWTKIGVWNSYTGLNLTEIKDNKNITDSLANRTLIVTTILENPYVM--YKKSDK 467

  Fly   424 -FTGNERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGS 487
             ..||:||.|:|:|:|:.:|..:||.|.:.||.|.||||:: :.|||||||.:|:.:.|||||..
Zfish   468 VLYGNDRFEGYCLDLLKELSNILGFTYEVKLVTDGKYGAQN-DKGEWNGMVRELIDHIADLAVAP 531

  Fly   488 MTITYARESVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIV 552
            :||||.||.||||:||||.||||||::.|......:|||:|||..:||:|||:|...||..::::
Zfish   532 LTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLTPDIWMYVLLACLGVSCVLFVI 596

  Fly   553 GKLSPIEWKCINACDLENISIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLI 617
            .:.:|.||...:.|:..:..:.|.|:|.:|.||.:...|:|..::.|:|:||||:...|.||:||
Zfish   597 ARFTPYEWYNPHPCNPSSEVVENNFTLLNSLWFGVAALMRQGSELMPKALSTRILGGIWWFFTLI 661

  Fly   618 IVASYTANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRDSVIETYKKIWRSMDN 682
            |::|||||||||||.|||.:||::|:|||.||.|.||.:..|||||||:.|.|.||:|:|..|.:
Zfish   662 IISSYTANLAAFLTVERMDSPIDSADDLAKQTRIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSS 726

  Fly   683 KKPSAFTTTYEDGIKRVNQGNYAFLMESTMLDYIVQRDCNLTQIGGLLDTKGYGIATPKGSPWRD 747
            :|.:|.....:|||.||...:||.|||||.::||.||:|||||:|||:|:||||:.||.|||:||
Zfish   727 RKNTALVKNSKDGITRVLTTDYALLMESTSIEYITQRNCNLTQVGGLIDSKGYGVGTPIGSPYRD 791

  Fly   748 KISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAV 812
            |:::|||:|||.|.:.|:.:|||:...  |..:::   .:|::||:|:|||:|:||.||::::..
Zfish   792 KVTIAILQLQEEGKLHMMKEKWWRGNG--CPEEDS---KEASALGVENIGGIFIVLAAGLVLSVF 851

  Fly   813 VAFFEFWYNFRYN 825
            ||..||.|....|
Zfish   852 VAIGEFIYKSHKN 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	123/397 (31%)
		ANF_receptor	39..371	CDD:279440	111/347 (32%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	193/371 (52%)
		Lig_chan	533..807	CDD:278489	133/273 (49%)
grik1a	XP_009303592.1	Periplasmic_Binding_Protein_Type_1	37..432	CDD:299141	125/402 (31%)
		ANF_receptor	57..398	CDD:279440	111/347 (32%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:304360	193/371 (52%)
		Lig_chan	577..846	CDD:278489	133/273 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591612
Domainoid	1	1.000	359	1.000	Domainoid score	I916
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.710