Protein Alignment Ekar and grik1a

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: XP_009303592.2
• Gene: grik1a / 798001
• ZFINID: ZDB-GENE-030131-6502
• Length: 919
• Species: Danio rerio
• Alignment Length: 858
• Identity: 342/858 - (39%)
• Similarity: 520/858 - (60%)
• Gaps: 55/858 - (6%)

  Fly     7 FLLFQFLSYGLGVPPLVRIGAIF---SNQPGMYNSELAFRYAIHRLNMDKSLLPETTVDYYVEYV 68
            |..:....:.|....::|||.||   .|:| :...||||::|:..:|.:::|:|.||:.|.::.|
Zfish    23 FFFYSMAKFYLSEQQVIRIGGIFETRENEP-VSMDELAFKFAVTSINRNRTLMPNTTLTYDIQRV 86

  Fly    69 NRFDSFETVQKVCKLIRVGVQAVFSPTDSVLATHINSICDALDIPNI-GRSAH-------DFSIN 125
            |.|||||..::||..:.:||.|||.|:.|...:.:.|||:||::|:| .|..|       :|.||
Zfish    87 NLFDSFEASRRVCDQLALGVAAVFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNKDNFYIN 151

  Fly   126 VYPSKQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQLSRS---FHGEVHMRQVSRDSYVS-- 185
            :||....::.|..|::.:..|....:::|...|::.:.:|.::   .:.::.:||:......|
Zfish   152 LYPEYTSISRAILDIVIFYKWKCVTVVYEDSTGLMRMQELIKAPSKNNLKIRIRQLPSGGGDSRP 216

  Fly   186 ALNEFKGKEIHNIIIDTNSNGISILLKNILQQ-QMNEYKYHYLFTSFDLETYDLEDFKYNFVNIT 249
            .|.|.|.::...:|.|.:....:.|||.::.. .|.|| ||:.||:.||...|||.::|:.||:|
Zfish   217 LLKEMKKEKEFYVIFDCSYQVAAELLKQLMSMGMMTEY-YHFFFTTLDLFALDLEPYRYSGVNMT 280

  Fly   250 SFRLVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGLQTLEQ 314
            :|||::..|..|..:::...:.......||...|   .|.|:.:..|||:|:|::.|:..|...|
Zfish   281 AFRLLNLDDSYVASVIQKWSMERQLAPPKPESGL---MSGIMTTAAALMYDAVFMVAVASQRATQ 342

  Fly   315 SHSLTLLNISCEEENSWDGGLSLINYLNAVEWKGLTGPIQFK--DGQRVQFKLDLIKLKQHSI-- 375
               :|:.::.|.....|..|...:|.....:|.||||.|...  ||.|.:|.||||.||:...
Zfish   343 ---MTVSSLQCHRHKPWRYGPRFMNLFKEAQWDGLTGRIVLNKTDGLRKEFNLDLISLKEDGTAK 404

  Fly   376 -------------VKVGEWTPHGHLNITE--PSMFFDAGSMNVTLVVITILETPYVMMHYGKN-- 423
                         .|:|.|..:..||:||  .:........|.||:|.||||.||||  |.|:
Zfish   405 RVADGASRPNKLWTKIGVWNSYTGLNLTEIKDNKNITDSLANRTLIVTTILENPYVM--YKKSDK 467

  Fly   424 -FTGNERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGS 487
             ..||:||.|:|:|:|:.:|..:||.|.:.||.|.||||:: :.|||||||.:|:.:.|||||..
Zfish   468 VLYGNDRFEGYCLDLLKELSNILGFTYEVKLVTDGKYGAQN-DKGEWNGMVRELIDHIADLAVAP 531

  Fly   488 MTITYARESVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIV 552
            :||||.||.||||:||||.||||||::.|......:|||:|||..:||:|||:|...||..::::
Zfish   532 LTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLTPDIWMYVLLACLGVSCVLFVI 596

  Fly   553 GKLSPIEWKCINACDLENISIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLI 617
            .:.:|.||...:.|:..:..:.|.|:|.:|.||.:...|:|..::.|:|:||||:...|.||:||
Zfish   597 ARFTPYEWYNPHPCNPSSEVVENNFTLLNSLWFGVAALMRQGSELMPKALSTRILGGIWWFFTLI 661

  Fly   618 IVASYTANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRDSVIETYKKIWRSMDN 682
            |::|||||||||||.|||.:||::|:|||.||.|.||.:..|||||||:.|.|.||:|:|..|.:
Zfish   662 IISSYTANLAAFLTVERMDSPIDSADDLAKQTRIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSS 726

  Fly   683 KKPSAFTTTYEDGIKRVNQGNYAFLMESTMLDYIVQRDCNLTQIGGLLDTKGYGIATPKGSPWRD 747
            :|.:|.....:|||.||...:||.|||||.::||.||:|||||:|||:|:||||:.||.|||:||
Zfish   727 RKNTALVKNSKDGITRVLTTDYALLMESTSIEYITQRNCNLTQVGGLIDSKGYGVGTPIGSPYRD 791

  Fly   748 KISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAV 812
            |:::|||:|||.|.:.|:.:|||:...  |..:::   .:|::||:|:|||:|:||.||::::..
Zfish   792 KVTIAILQLQEEGKLHMMKEKWWRGNG--CPEEDS---KEASALGVENIGGIFIVLAAGLVLSVF 851

  Fly   813 VAFFEFWYNFRYN 825
            ||..||.|....|
Zfish   852 VAIGEFIYKSHKN 864

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	125/399 (31%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	193/371 (52%)
		Lig_chan	532..806	CDD:459656	132/273 (48%)
grik1a	XP_009303592.2	None