DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ekar and grid1a

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	XP_021323097.1	Gene:	grid1a / 793756	ZFINID:	ZDB-GENE-120411-28	Length:	1044	Species:	Danio rerio

Alignment Length:	889	Identity:	248/889 - (27%)
Similarity:	438/889 - (49%)	Gaps:	119/889 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LVRIGAIFSNQPGMYNSELAFRYAIHRLNMDKSLLPETTVDYYVEYVNRFDSFETVQKVCKLIRV 86
            ::.||||| .|..:.:.|: |:.||..|:::..:|....:.:.::.:...:.|:.||:.|:|:..
Zfish    23 IIHIGAIF-EQNAIRDDEV-FQLAISDLSLNDDILQSERITHSIKLIEPNNPFQAVQEACELMNQ 85

  Fly    87 GVQAVFSPTDSVLATHINSICDALDIPNI-------GRSAHDFSINVYPSKQLVNYA------FN 138
            |:.|:.|.|....|..:.|:.||:.||::       |....:..:|..|..:....|      .|
Zfish    86 GILALVSSTGCAAANALQSLTDAMHIPHLFIQRNGDGTPRAECQLNPSPDGERYTLAARPPVRLN 150

  Fly   139 DV----IQYLNWTRFGILHEKENGIINLH----QLSRSFHG-EVHMRQVSRD-----------SY 183
            ||    :..|.|.:|.:.::.|..:..|.    |.||.  | :|.::||.|:           ..
Zfish   151 DVMITLVSELRWHKFIVFYDSEYDVRGLRGFLDQASRM--GLDVSLQQVDRNVTKVFSTLFSTMR 213

  Fly   184 VSALNEFKGKEIHNIIIDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETYDLEDFKYNFVNI 248
            :..||.:: ..:...|:..:.....:.:...::..:.....|:::.:.::...::
Zfish   214 MEELNRYR-DTLRRAILLLSPRTAQVFIHQAVETNLASKDSHWVYANEEVSDTEI---------- 267

  Fly   249 TSFRLVDTADVG----VKQIL---KDIGL----YSHHIF------KKPYLNLHIKKSTILESEPA 296
              ..||.:| :|    ::||.   :|..:    .:|.|.      ::.||.       .||....
Zfish   268 --MELVHSA-LGRMTVIRQIFPLWRDTNIRCMRNNHRISSLLCDPQEGYLQ-------SLEVSSL 322

  Fly   297 LMFDSVYVFAIGL-QTLEQS--HSLTLLNISCEEENSWDGGLSLINYLNAVEWKGLTGPIQFKD- 357
            .::|||.:.|... :.||..  ||:..||...:....|:||.|:::.:......||||.:.|:.
Zfish   323 YLYDSVLMLANAFYRKLEDRKWHSMASLNCMRKSTKPWNGGWSMLDTIQKGRISGLTGLMDFRSN 387

  Fly   358 --GQRVQFKL---DLIKLKQHSIVKVGEWTPHGHLNITEPSMFFDAGSMNVTLVVITILETPYVM 417
              ...|||::   ...:.....:.::..|.....||.:......|.|...:||.|:|:||.|:||
Zfish   388 GANSHVQFEILGTSYSETFGKDVKRLATWDSDRGLNGSLRENRADHGMQGITLKVVTLLEEPFVM 452

  Fly   418 MHYGKNFTGN-ERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPET-GEWNGMVAQLMKYK 480
            :  .:|..|. :|:.||.:|:|:.:::.:||.|.:..|.|.|||:  |:| |.||||:.:|:..:
Zfish   453 V--AENILGQPKRYKGFSIDVLDALAKILGFKYEMYQVADAKYGS--PQTNGSWNGMIGELIGKR 513

  Fly   481 ADLAVGSMTITYARESVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLV 545
            ||:|:.::|||..||:|:||:|.:::..:.||. ..|.|...:||.:.|..:.:|..:..|..:|
Zfish   514 ADVAISAITITPERENVVDFSKRYLDYSVGILM-TKTEERLNIFSLLAPFDLAVWACIAAAIPVV 577

  Fly   546 SLCIYIVGKLSPIEWKCINACDLENISIGNQ-FSLTDSF----WFTIGTFMQQSPDIYPRAMSTR 605
            .:.::::.::..:.        .:|....:| .|:|.||    |...|.|:||..:.:..:|:.|
Zfish   578 GVMVFLLRRVQSVR--------SQNPPGPHQPASVTTSFQSAIWIVYGAFVQQGGESFMSSMALR 634

  Fly   606 IISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFR---- 666
            |...:|..|:||:.:||||||||:||..||.|.|...:||:.|:||:|||:...:...:||
Zfish   635 IAMGSWWLFTLIVCSSYTANLAAYLTVSRMDNAIRTFQDLSKQSEINYGTVRESAVFEYFRVKGT 699

  Fly   667 -----DSVIETYKKIWRSMD-NKKPSAFTTTYEDGIKRVNQGNYAFLMESTMLDY--IVQRDCNL 723
                 ||   |:.::||::: |:......|:..:||::|.:..||||.:..:|:|  :...||.|
Zfish   700 NPLEQDS---TFAELWRTINKNQGQDNSVTSPAEGIRKVKRDPYAFLWDMAVLEYAALTDDDCTL 761

  Fly   724 TQIGGLLDTKGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKA 788
            ...|..:.:||||:|...|||:||..|..||:|||:||:.:|..|||.........|:...|::.
Zfish   762 VVTGNGMSSKGYGLALQHGSPYRDLFSQKILDLQEKGDLDILKQKWWPRKGRCDLDKHAEPQTEG 826

  Fly   789 NSLGLESIGGVFVVLIAGIIVAAVVAFFEFWYNFRYNYEATPSQ 832
            .:|.|.|..|||.:|.||:::|.:||..|.|:|......|.|.:
Zfish   827 RALRLHSFAGVFCILAAGLLLACLVAALESWWNGPRCQRAQPKE 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	87/422 (21%)
		ANF_receptor	39..371	CDD:279440	80/390 (21%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	137/387 (35%)
		Lig_chan	533..807	CDD:278489	97/290 (33%)
grid1a	XP_021323097.1	Periplasmic_Binding_Protein_Type_1	25..424	CDD:324556	88/423 (21%)
		PBP2_iGluR_delta_1	437..809	CDD:270448	137/387 (35%)
		DNA_pol3_gamma3	<915..1044	CDD:331207
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591153
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.840