Protein Alignment Ekar and Grid1

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_077354.1
• Gene: Grid1 / 79219
• RGDID: 68366
• Length: 1009
• Species: Rattus norvegicus
• Alignment Length: 891
• Identity: 250/891 - (28%)
• Similarity: 436/891 - (48%)
• Gaps: 126/891 - (14%)

  Fly    22 LVRIGAIFSNQPGMYNSELAFRYAIHRLNMDKSLLPETTVDYYVEYVNRFDSFETVQKVCKLIRV 86
            ::.|||||.....  ..:..|:.|:..|:::..:|....:.|.::.:...:.|:.||:.|.|:..
  Rat    23 IIHIGAIFEENAA--KDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEACDLMTQ 85

  Fly    87 GVQAVFSPTDSVLATHINSICDALDIPNI-------GRSAHDFSINVYPSKQLVNYA------FN 138
            |:.|:.:.|....|..:.|:.||:.||::       |.......:|..|..:....|      .|
  Rat    86 GILALVTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYTLASRPPVRLN 150

  Fly   139 DV----IQYLNWTRFGILHEKENGIINLH----QLSRSFHGEVHMRQVSRD---SYVSALNEFKG 192
            ||    :..|.|.:|.:.::.|..|..|.    |.|| ...:|.:::|.::   .:.|.....|.
  Rat   151 DVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASR-LGLDVSLQKVDKNISHVFTSLFTTMKT 214

  Fly   193 KEIHNIIIDTNSNGISIL--------LKNILQQQMNEYKYHYLFTSFDLETYDLEDFKYNFV-NI 248
            :|: |...||....|.:|        :...::..:.....|::|.:.::...::.|..::.: .:
  Rat   215 EEL-NRYRDTLRRAILLLSPQGAHSFINEAVETNLASKDSHWVFVNEEISDPEILDLVHSALGRM 278

  Fly   249 TSFRLVDTADVGVKQILKDIGLYSHHIF------KKPYLNLHIKKSTILESEPALMFDSVYVFAI 307
            |..|.:..:....::.:::    :|.|.      ::.||.:       |:.....::|||.:.|.
  Rat   279 TVVRQIFPSAKDNQKCMRN----NHRISSLLCDPQEGYLQM-------LQISNLYLYDSVLMLAN 332

  Fly   308 GL-QTLEQS--HSLTLLNISCEEENSWDGGLSLINYLNAVEWKGLTGPIQFKDGQR---VQFKL- 365
            .. :.||..  ||:..||...:....|:||.|:::.:......||||.::|::...   |||::
  Rat   333 AFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIKKGHITGLTGVMEFREDSSNPYVQFEIL 397

  Fly   366 ----------DLIKLKQHSIVKVGEWTPHGHLN--ITEPSMFFDAGS--MNVTLVVITILETPYV 416
                      |:.||        ..|.....||  :.|..|    ||  ..:||.|:|:||.|:|
  Rat   398 GTTYSETFGKDMRKL--------ATWDSEKGLNGSLQERPM----GSRLQGLTLKVVTVLEEPFV 450

  Fly   417 MMHYGKNFTGN-ERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYK 480
            |:  .:|..|. :|:.||.:|:|:.:::.:||.|.:...||.:||.:...| .||||:.:|:..:
  Rat   451 MV--AENILGQPKRYKGFSIDVLDALAKALGFKYEIYQAPDGRYGHQLHNT-SWNGMIGELISKR 512

  Fly   481 ADLAVGSMTITYARESVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLV 545
            ||||:.::|||..||||:||:|.:|:..:.||.|.| .|...:||...|....:|..:..|..:|
  Rat   513 ADLAISAITITPERESVVDFSKRYMDYSVGILIKKP-EEKISIFSLFAPFDFAVWACIAAAIPVV 576

  Fly   546 SLCIYIVGKLSPIEWKCINACDLENISIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISST 610
            .:.|:::.::     :.:.:............:|..:.|...|.|:||..:....:::.||:..:
  Rat   577 GVLIFVLNRI-----QAVRSQSATQPRPSASATLHSAIWIVYGAFVQQGGESSVNSVAMRIVMGS 636

  Fly   611 WGFFSLIIVASYTANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFR--------- 666
            |..|:||:.:|||||||||||..||.:|:...:||:.|.|:||||:...:...:||
  Rat   637 WWLFTLIVCSSYTANLAAFLTVSRMDSPVRTFQDLSKQLEMSYGTVRDSAVYEYFRAKGTNPLEQ 701

  Fly   667 DSVIETYKKIWRSM------DN--KKPSAFTTTYEDGIKRVNQGNYAFLMESTMLDY--IVQRDC 721
            ||   |:.::||::      ||  ..||       :||::..:||||||.:..:::|  :...||
  Rat   702 DS---TFAELWRTISKNGGADNCVSNPS-------EGIRKAKKGNYAFLWDVAVVEYAALTDDDC 756

  Fly   722 NLTQIGGLLDTKGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQS 786
            ::|.||..:.:||||||...|||:||..|..|||||:.||:.:|..|||.:|.......::|.|:
  Rat   757 SVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHTGRCDLTSHSSAQT 821

  Fly   787 KANSLGLESIGGVFVVLIAGIIVAAVVAFFEFWYNFRYNYEATPSQ 832
            ...||.|.|..|||.:|..|:::|.:||..|.|:|....::.||.:
  Rat   822 DGKSLKLHSFAGVFCILAIGLLLACLVAALELWWNSNRCHQETPKE 867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	88/423 (21%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	137/388 (35%)
		Lig_chan	532..806	CDD:459656	97/292 (33%)
Grid1	NP_077354.1	Interaction with CBLN1. /evidence=ECO:0000250|UniProtKB:Q61627	21..436		92/439 (21%)
		PBP1_iGluR_delta_1	25..425	CDD:380615	88/422 (21%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	137/388 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	931..960