DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ekar and grin2aa

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	XP_021329529.1	Gene:	grin2aa / 563297	ZFINID:	ZDB-GENE-070424-129	Length:	1460	Species:	Danio rerio

Alignment Length:	853	Identity:	219/853 - (25%)
Similarity:	366/853 - (42%)	Gaps:	159/853 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 VNRFDSFETVQKVCKLIRVGVQ---AVFSP-TD-SVLATHINSICDALDIPNIGRSAHDFSINVY 127
            ||..|....:..||.|:. |.:   .||.. || ..:|..::.|.....||.:|  .|..|..:.
Zfish    71 VNETDPKSIITHVCDLMS-GTKIHGVVFGDGTDQEAIAQILDFISSQTLIPILG--IHGGSSMIM 132

  Fly   128 PSKQLVNYAFN-------------DVIQYLNWTRFGILHEKENGIINLHQLSRSFHGEVHMRQVS 179
            ..|.:.:..|.             ::::..:|..|.|:..|..|          :...:.:.:.:
Zfish   133 ADKDVKSTFFQFGASIQQEALLMLNIMEEYDWHVFSIVTSKFPG----------YQDFIAILKTT 187

  Fly   180 RDSYVSALNEFKGKEIHNII----IDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETYDLED 240
            .|      |.|.|.::.:||    :|.:|. ..|.||.:....:      .|:.|.|...|.||:
Zfish   188 VD------NSFVGWDLQHIITLDAVDGDSR-TQIQLKKVQSPVV------LLYCSKDEAAYILEE 239

  Fly   241 FKYNFVNITSFR---LVDTADVGVKQILKDI---GLYSHHIFKKPY-LNLHIKKST-ILESEPAL 297
            .:  .:.:|.|.   :|.:...|..:|..|.   |:.|.......| |...::... |:.:..|.
Zfish   240 AR--SLGLTGFGYIWIVPSLTTGNPEITPDTFPSGMISVSYDDWDYPLEARVRDGLGIITTAAAA 302

  Fly   298 MFDSVYVFAIGLQTLEQSHSLTLLNISC--EEENSWDGGLSLINYLNAVEWKGLTGPIQF-KDGQ 359
            |             ||:...:.....||  :.|.:.....:|..|:..|.|.|  ..:.| :||.
Zfish   303 M-------------LEEFGDIPEAKTSCYGQMEKTKLPPSALHKYMMNVTWDG--KDLSFTEDGY 352

  Fly   360 RVQFKLDLIKL-KQHSIVKVGEWTPHGHLNITEP-----SMFFDAGSMNVTLVVITILETPYVMM 418
            :|..||.:|.| |.....|:|:| .:..|.:..|     :.|.||.:.:..|.::|:.|.|:|::
Zfish   353 QVHPKLVVIVLNKDREWEKMGKW-ENQSLTLKYPVWPRFNSFGDAETDDNHLTIVTLEEKPFVIV 416

  Fly   419 -------------------HYGKNFTGNERFY------GFCVDILETISREVGFDYILDLVPDRK 458
                               |...|.|.....|      |||:|||:.|:|.|.|.|.|.||.:.|
Zfish   417 ENVERLTGTCMRNSVPCRKHIKDNTTEGGGTYIKKCCKGFCIDILKKIARNVKFTYDLYLVTNGK 481

  Fly   459 YGAKDPETGEWNGMVAQLMKYKADLAVGSMTITYARESVIDFTKPFMNLGISILFKVP--TSEPT 521
            :|.|  ....|||||.:::..||.:||||:||...|..||||:.||:..|||::....  |..|:
Zfish   482 HGKK--INNVWNGMVGEVVNKKAVMAVGSLTINEERSEVIDFSVPFVETGISVMVSRSNGTVSPS 544

  Fly   522 RLFSFMNPLAIEIWIYVLIAYFLV-SLCIYIVGKLSPIEWKCINACDLENISIGN-----QFSLT 580
               :|:.|.:..:|:.:.:...|| ::.:::...:||:.:.       .|::.|.     .|::.
Zfish   545 ---AFLEPFSASVWVMMFVMLLLVTAMAVFMFEYISPLGFN-------RNLAQGKDPHGPSFTMG 599

  Fly   581 DSFWFTIG-TFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAED 644
            .:.|...| .|....|...|:..:::.|.|.|.||::|.:||||||||||:..|..::.:....|
Zfish   600 KAVWLLWGLVFNNSVPVQNPKGTTSKFIVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSD 664

  Fly   645 LASQTEISY------GTLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYEDGIKRVNQGN 703
            ...|:..||      ||:.:|||.        ...:|.:..|.........|...|.:..:..|.
Zfish   665 KKFQSPYSYSPPFRFGTVPNGSTE--------RNIRKNYPDMHQYMVKYHQTGVNDALVSLKTGK 721

  Fly   704 Y-AFLMESTMLDYIVQRD--CNLTQIGG--LLDTKGYGIATPKGSPWRDKISLAILELQERGDIQ 763
            . ||:.::.:|:|:..||  |.|..||.  :..|.|||||..|||.|:..:.||||.:...|:::
Zfish   722 LDAFIYDAAVLNYMAGRDEGCKLVTIGSGYIFATTGYGIALQKGSLWKRPVDLAILAIIGDGEME 786

  Fly   764 MLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFE--FWYNFRYNY 826
            .|..:|.     |....|...:..::.|.::::.|||.:|...:.::.:...:|  |::..||.:
Zfish   787 ELEAQWL-----TGICHNEKNEVMSSQLDVDNMAGVFYMLATAMGLSLITFVWEHLFYWRLRYCF 846

  Fly   827 ----EATP 830
                ..||
Zfish   847 TGVCSGTP 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	77/353 (22%)
		ANF_receptor	39..371	CDD:279440	73/336 (22%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	124/413 (30%)
		Lig_chan	533..807	CDD:278489	78/291 (27%)
grin2aa	XP_021329529.1	PBP1_iGluR_NMDA_NR2	33..389	CDD:107373	79/361 (22%)
		PBP2_iGluR_NMDA_Nr2	400..799	CDD:270436	125/423 (30%)
		NMDAR2_C	836..1460	CDD:313729	5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810