Protein Alignment Ekar and grin2aa

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: XP_021329529.1
• Gene: grin2aa / 563297
• ZFINID: ZDB-GENE-070424-129
• Length: 1460
• Species: Danio rerio
• Alignment Length: 858
• Identity: 219/858 - (25%)
• Similarity: 364/858 - (42%)
• Gaps: 169/858 - (19%)

  Fly    68 VNRFDSFETVQKVCKLIRVGVQ---AVFSP-TD-SVLATHINSICDALDIPNIGRSAHDFSINVY 127
            ||..|....:..||.|:. |.:   .||.. || ..:|..::.|.....||.:|  .|..|..:.
Zfish    71 VNETDPKSIITHVCDLMS-GTKIHGVVFGDGTDQEAIAQILDFISSQTLIPILG--IHGGSSMIM 132

  Fly   128 PSKQLVNYAFN-------------DVIQYLNWTRFGILHEKENGIINLHQLSRSFHGEVHMRQVS 179
            ..|.:.:..|.             ::::..:|..|.|:..|..|.
Zfish   133 ADKDVKSTFFQFGASIQQEALLMLNIMEEYDWHVFSIVTSKFPGY-------------------- 177

  Fly   180 RDSYVSAL-----NEFKGKEIHNII----IDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLET 235
             ..:::.|     |.|.|.::.:||    :|.:|. ..|.||.:....:      .|:.|.|...
Zfish   178 -QDFIAILKTTVDNSFVGWDLQHIITLDAVDGDSR-TQIQLKKVQSPVV------LLYCSKDEAA 234

  Fly   236 YDLEDFKYNFVNITSFR---LVDTADVGVKQILKDI---GLYSHHIFKKPY-LNLHIKKST-ILE 292
            |.||:.:  .:.:|.|.   :|.:...|..:|..|.   |:.|.......| |...::... |:.
Zfish   235 YILEEAR--SLGLTGFGYIWIVPSLTTGNPEITPDTFPSGMISVSYDDWDYPLEARVRDGLGIIT 297

  Fly   293 SEPALMFDSVYVFAIGLQTLEQSHSLTLLNISC--EEENSWDGGLSLINYLNAVEWKGLTGPIQF 355
            :..|.|             ||:...:.....||  :.|.:.....:|..|:..|.|.|  ..:.|
Zfish   298 TAAAAM-------------LEEFGDIPEAKTSCYGQMEKTKLPPSALHKYMMNVTWDG--KDLSF 347

  Fly   356 -KDGQRVQFKLDLIKL-KQHSIVKVGEWTPHGHLNITEP-----SMFFDAGSMNVTLVVITILET 413
             :||.:|..||.:|.| |.....|:|:| .:..|.:..|     :.|.||.:.:..|.::|:.|.
Zfish   348 TEDGYQVHPKLVVIVLNKDREWEKMGKW-ENQSLTLKYPVWPRFNSFGDAETDDNHLTIVTLEEK 411

  Fly   414 PYVMM-------------------HYGKNFTGNERFY------GFCVDILETISREVGFDYILDL 453
            |:|::                   |...|.|.....|      |||:|||:.|:|.|.|.|.|.|
Zfish   412 PFVIVENVERLTGTCMRNSVPCRKHIKDNTTEGGGTYIKKCCKGFCIDILKKIARNVKFTYDLYL 476

  Fly   454 VPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTITYARESVIDFTKPFMNLGISILFKVP-- 516
            |.:.|:|.|  ....|||||.:::..||.:||||:||...|..||||:.||:..|||::....
Zfish   477 VTNGKHGKK--INNVWNGMVGEVVNKKAVMAVGSLTINEERSEVIDFSVPFVETGISVMVSRSNG 539

  Fly   517 TSEPTRLFSFMNPLAIEIWIYVLIAYFLV-SLCIYIVGKLSPIEWKCINACDLENISIGN----- 575
            |..|:   :|:.|.:..:|:.:.:...|| ::.:::...:||:.:.       .|::.|.
Zfish   540 TVSPS---AFLEPFSASVWVMMFVMLLLVTAMAVFMFEYISPLGFN-------RNLAQGKDPHGP 594

  Fly   576 QFSLTDSFWFTIG-TFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERMINPI 639
            .|::..:.|...| .|....|...|:..:::.|.|.|.||::|.:||||||||||:..|..::.:
Zfish   595 SFTMGKAVWLLWGLVFNNSVPVQNPKGTTSKFIVSVWAFFAVIFLASYTANLAAFMIQEEFVDQV 659

  Fly   640 ENAEDLASQTEISY------GTLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYEDGIKR 698
            ....|...|:..||      ||:.:|||.        ...:|.:..|.........|...|.:..
Zfish   660 TGLSDKKFQSPYSYSPPFRFGTVPNGSTE--------RNIRKNYPDMHQYMVKYHQTGVNDALVS 716

  Fly   699 VNQGNY-AFLMESTMLDYIVQRD--CNLTQIGG--LLDTKGYGIATPKGSPWRDKISLAILELQE 758
            :..|.. ||:.::.:|:|:..||  |.|..||.  :..|.|||||..|||.|:..:.||||.:..
Zfish   717 LKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGYIFATTGYGIALQKGSLWKRPVDLAILAIIG 781

  Fly   759 RGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFE--FWYN 821
            .|:::.|..:|.     |....|...:..::.|.::::.|||.:|...:.::.:...:|  |::.
Zfish   782 DGEMEELEAQWL-----TGICHNEKNEVMSSQLDVDNMAGVFYMLATAMGLSLITFVWEHLFYWR 841

  Fly   822 FRYNY----EATP 830
            .||.:    ..||
Zfish   842 LRYCFTGVCSGTP 854

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	78/360 (22%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	124/413 (30%)
		Lig_chan	532..806	CDD:459656	78/291 (27%)
grin2aa	XP_021329529.1	PBP1_iGluR_NMDA_NR2	33..384	CDD:380601	78/361 (22%)
		PBP2_iGluR_NMDA_Nr2	400..799	CDD:270436	125/423 (30%)
		NMDAR2_C	836..1460	CDD:463148	5/19 (26%)