DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ekar and grik4

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	XP_021322087.1	Gene:	grik4 / 556582	ZFINID:	ZDB-GENE-070821-5	Length:	965	Species:	Danio rerio

Alignment Length:	867	Identity:	316/867 - (36%)
Similarity:	478/867 - (55%)	Gaps:	69/867 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLIASGFLLF--QFLSYGLGVPPLVRIGAIFSNQPGMYNSE-LAFRYAIHRLN--MDKSLLPETT 60
            ||.|...|||  .::......|...||.||..:.......| ||...|...:|  .::|...:..
Zfish     1 MLAAWAPLLFLAMWVRNATSGPLSFRIAAILDDPMECSRGERLAITLAKDSINRSSNRSTTGKLE 65

  Fly    61 VDYYVEYVNRFDSFETVQKVCKLIRVGVQAVFSPTDSVLATH-INSICDALDIPNIGRSAHDF-- 122
            ||.:  .:.|...:||.:.:|:::..||.||..|:.|..:.. |::||...::|.:..:..|.
Zfish    66 VDIF--ELLRDSEYETGETMCQIMSKGVVAVLGPSASPASNSIISNICGEKEVPYVKVAPEDILK 128

  Fly   123 -------SINVYPSKQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQLSRSF-----HGEVHM 175
                   ::::.|:...::.|...::.:.|.:...::..:.:.::||..|.|.|     ...|.|
Zfish   129 VQFPRFTTLDLRPTNTDISMAVAGLLTFFNSSTSCLICAQADCLLNLEVLLRQFLISKETLSVRM 193

  Fly   176 RQVSRDSYVSALNEFKGKEIHNIIIDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETYDLED 240
            ...|:|. ...|.|.:..:...||:|.|:....::|:...:..|....|.|:.||.:.....|:|
Zfish   194 LDDSQDP-TPLLKEIRDDKTATIIVDANATMSHVILERASELGMLSVYYTYILTSLEFSLLRLDD 257

  Fly   241 FKYNFVNITSFRLVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESEP--------AL 297
            .....|||..|.:.:.               :|..|:...|:|:.......:..|        ||
Zfish   258 LADQRVNIVGFSVFNR---------------THPFFQDFVLSLNRSWQENCDHAPFAGTPLSSAL 307

  Fly   298 MFDSVYVFAIGLQTLEQSHSLTLLNISCEEENSWDGGLSLINYLNAVEWKGLTGPIQFKD-GQRV 361
            :||:|:.....:|.|.:|.::....:||:....|:.|.||:|||..||.:||||.|:|.. |||.
Zfish   308 LFDAVHTVVAAVQELNRSQNVGATQLSCKSSKIWEHGTSLMNYLRMVELEGLTGHIEFNSKGQRS 372

  Fly   362 QFKLDLIKLKQHSIVKVGEWTPHGHLNITE--PSMFFDAGSMNVTLVVITILETPYVMMHYG-KN 423
            .:.|.:::..:..:.::|:|.....|::..  ||:.......|.||.:.||||.||||:... :.
Zfish   373 NYALRIMQNSRDGLRQIGQWHSEQGLSMERKLPSLNVTDTLFNTTLTITTILENPYVMLRANHQE 437

  Fly   424 FTGNERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSM 488
            ..||:|:.|||||:|:.::..:.|.|.:.||.|..||... ..|.|.|||.:|:..||||||.::
Zfish   438 LEGNDRYEGFCVDMLKELADILKFKYRIRLVGDGVYGVPG-ANGTWTGMVGELISRKADLAVAAL 501

  Fly   489 TITYARESVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVG 553
            |||..||.||||:||||.|||||:::|........|||::|.:..:|:::|:||..||..:::|.
Zfish   502 TITAEREKVIDFSKPFMTLGISIMYRVHIGRRPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVA 566

  Fly   554 KLSPIEW----KCINA-CDLENISIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISSTWGF 613
            :|:|.||    .|:.. |.|    :.||:||.:||||.:|.||||...|.|||:|||.:|..|..
Zfish   567 RLTPYEWYNPHPCLKGRCSL----LINQYSLGNSFWFPVGGFMQQGSTIAPRALSTRCVSGVWWA 627

  Fly   614 FSLIIVASYTANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRDSVIETYKKIWR 678
            |:|||::|||||||||||.:||..|||:.:|||.||.|.|||:..|||||||::|..:||:::|.
Zfish   628 FTLIIISSYTANLAAFLTVQRMEVPIESVDDLADQTAIEYGTMHGGSTMTFFQNSRYQTYQRMWN 692

  Fly   679 SMDNKKPSAFTTTYEDGIKRVNQGNYAFLMESTMLDYIVQRDCNLTQIGGLLDTKGYGIATPKGS 743
            .|.:|:||.|..:.|:||.||...|||:|:||||.:|..||:|||||||||||||||||..|.||
Zfish   693 FMYSKQPSVFVKSTEEGIARVLNSNYAYLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPLGS 757

  Fly   744 PWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGII 808
            .:||:..||||.|||...:::|..|||..  ..|.::   :..:|..||:|:|||:||||:.|::
Zfish   758 VYRDEFDLAILRLQEENRLEILKRKWWDG--GKCPKE---EDHRAKGLGMENIGGIFVVLVCGLL 817

  Fly   809 VAAVVAFFEFWYNFRYNYEATP 830
            ||..:|..||.:..|:    ||
Zfish   818 VAIFMAVLEFVWMLRH----TP 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	93/390 (24%)
		ANF_receptor	39..371	CDD:279440	87/358 (24%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	191/374 (51%)
		Lig_chan	533..807	CDD:278489	142/278 (51%)
grik4	XP_021322087.1	Periplasmic_Binding_Protein_Type_1	26..400	CDD:324556	94/391 (24%)
grik4	XP_021322087.1	PBP2_iGluR_kainate_KA1	425..785	CDD:270442	185/364 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590983
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.610