back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ekar and Gria3

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_001268858.2	Gene:	Gria3 / 53623	MGIID:	95810	Length:	888	Species:	Mus musculus

Alignment Length:	909	Identity:	321/909 - (35%)
Similarity:	484/909 - (53%)	Gaps:	102/909 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLIASGFLLFQFL--SYGLGVPPLVRIGAIFSNQPGMYNSELAFRYAIHRLNMDKSLLPETT--- 60
            :|.|..||:...|  |:| |.|..:.||.:|.......:|  |||:|:...|.:::    ||
Mouse     5 VLRAVFFLVLGLLGHSHG-GFPNTISIGGLFMRNTVQEHS--AFRFAVQLYNTNQN----TTEKP 62

  Fly    61 --VDYYVEYVNRFDSFETVQKVCKLIRVGVQAVFSPTDSVLATHINSICDALD----IPNIGRSA 119
              ::|:|::::..:||......|.....||.|:|...|.:....:.|.|.||.    .|:....|
Mouse    63 FHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFPTDA 127

  Fly   120 H-DFSINVYPSKQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQLSRSF---HGEVHMRQVSR 180
            . .|.|.:.|:   :..|...::.|..|.:|..|::.|.|...|..:..:.   :.:|..|.|..
Mouse   128 DVQFVIQMRPA---LKGAILSLLGYYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGN 189

  Fly   181 ----DSYVSALNEFKGKEIHNIIIDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETYDLEDF 241
                ..:...:.|...::....:||.....|:.:|:.::....:...|||:..:.......||..
Mouse   190 IKDIQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTDIVLERV 254

  Fly   242 KYNFVNITSFRLVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFA 306
            .:...|||.|::|:..:..|:|.::.........|.:       .|:..|:...||..|::.|.|
Mouse   255 MHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPE-------AKNAPLKYTSALTHDAILVIA 312

  Fly   307 IGLQTLEQSHSLTLLNISCEEENS-----------WDGGLSLINYLNAVEWKGLTGPIQFKD-GQ 359
            ...:.|.:.      .:......|           |..|:.:...|..|:.:|:||.|||.. |:
Mouse   313 EAFRYLRRQ------RVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDTYGR 371

  Fly   360 RVQFKLDLIKLKQHSIVKVGEW------TPHGHLNITEPSMFFDAGSMNVTLVVITILETPYVMM 418
            |..:.:|:.::|.....|.|.|      .|.....|:..|    :.|.|.|:||.||||:||||
Mouse   372 RTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDS----SSSENRTIVVTTILESPYVM- 431

  Fly   419 HYGKN---FTGNERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYK 480
             |.||   ..||||:.|:|||:...|::.|...|.|.:|.|.||||:||||..|||||.:|:..:
Mouse   432 -YKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGR 495

  Fly   481 ADLAVGSMTITYARESVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLV 545
            ||:||..:|||..||.||||:||||:|||||:.|.|......:|||::|||.|||:.::.||..|
Mouse   496 ADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGV 560

  Fly   546 SLCIYIVGKLSPIEWKCINACDLENIS-----------IGNQFSLTDSFWFTIGTFMQQSPDIYP 599
            |:.:::|.:.||.||      .||:.:           ..|:|.:.:|.||::|.||||..||.|
Mouse   561 SVVLFLVSRFSPYEW------HLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISP 619

  Fly   600 RAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTF 664
            |::|.||:...|.||:|||::|||||||||||.|||::|||:|||||.||||:|||||||||..|
Mouse   620 RSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEF 684

  Fly   665 FRDSVIETYKKIWRSMDNKKPSAFTTTYEDGIKRV--NQGNYAFLMESTMLDYIVQR-DCNLTQI 726
            ||.|.|..|:|:|..|.:.:||.||.|..||:.||  ::|.:|||:||||.:||.|| .|:..::
Mouse   685 FRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKV 749

  Fly   727 GGLLDTKGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSL 791
            ||.||:||||:||||||..|..::||:|:|.|:|.:..|.:|||.:..| |..|::..:.|.::|
Mouse   750 GGNLDSKGYGVATPKGSALRTPVNLAVLKLSEQGILDKLKNKWWYDKGE-CGAKDSGSKDKTSAL 813

  Fly   792 GLESIGGVFVVLIAGIIVAAVVAFFEFWYNFR------------YNYEATPSQSVVNNKYNQDG 843
            .|.::.|||.:|:.|:.:|.:||..||.|..|            .|::..|:.:..|....::|
Mouse   814 SLSNVAGVFYILVGGLGLAMMVALIEFCYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREG 877

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.