back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ekar and Gria1

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_113796.1	Gene:	Gria1 / 50592	RGDID:	621531	Length:	907	Species:	Rattus norvegicus

Alignment Length:	886	Identity:	319/886 - (36%)
Similarity:	487/886 - (54%)	Gaps:	84/886 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 GLGVPPLVRIGAIFSNQPGMYNSELAFRYAIHRLNMDKSLLPETTVDYYVEYVNRFDSFETVQKV 80
            |...|..::||.:|.||....::  |||:|:.:|.....|||:      ::.||..||||...:.
  Rat    18 GANFPNNIQIGGLFPNQQSQEHA--AFRFALSQLTEPPKLLPQ------IDIVNISDSFEMTYRF 74

  Fly    81 CKLIRVGVQAVFSPTDSVLATHINSICDALDIPNIGRS-----AHDFSINVYPSKQLVNYAFNDV 140
            |.....||.|:|...:......:.|.|.||.:..|..|     ::.|.:.:.|..|   .|...:
  Rat    75 CSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTSNQFVLQLRPELQ---EALISI 136

  Fly   141 IQYLNWTRFGILHEKENGIINLHQLSRSFHGE------VHMRQVSRDSYVSALNEFKGKEIHNII 199
            |.:..|..|..:::.:.|:..|.::..:...:      |::...:.:.|.....:.:.|:...::
  Rat   137 IDHYKWQTFVYIYDADRGLSVLQRVLDTAAEKNWQVTAVNILTTTEEGYRMLFQDLEKKKERLVV 201

  Fly   200 IDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETYDLEDFKYNFVNITSFRLVDTADVGVKQI 264
            :|..|..::.:|..|::.:.|...|||:..:......||..||.:..|:|.|:||:..|....:|
  Rat   202 VDCESERLNAILGQIVKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPARI 266

  Fly   265 LK-----DIGLYSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGLQTLEQSHSLTLLNIS 324
            ::     |...::...:|:|       |.|     .||.:|.|.|.|...|:|.:..    ::||
  Rat   267 MQQWRTSDSRDHTRVDWKRP-------KYT-----SALTYDGVKVMAEAFQSLRRQR----IDIS 315

  Fly   325 -------CEEENS--WDGGLSLINYLNAVEWKGLTGPIQFKD-GQRVQFKLDLIKLKQHSIVKVG 379
                   |....:  |..|:.:...|..|.::||||.:||.: |:|..:.|.:|::|...|.|:|
  Rat   316 RRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGRRTNYTLHVIEMKHDGIRKIG 380

  Fly   380 EWTPHGHLNITEPSMFFDAGS-----------MNVTLVVITILETPYVMMHYGKN-FTGNERFYG 432
            .|        .|...|..|.:           .|.|.:|.||||.||||:....| |.||:|:.|
  Rat   381 YW--------NEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPYVMLKKNANQFEGNDRYEG 437

  Fly   433 FCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTITYARESV 497
            :||::...|::.||:.|.|::|.|.||||:||:|..|||||.:|:..:||:||..:|||..||.|
  Rat   438 YCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEV 502

  Fly   498 IDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEW-- 560
            |||:||||:|||||:.|.|......:|||::|||.|||:.::.||..||:.:::|.:.||.||
  Rat   503 IDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHS 567

  Fly   561 -KCINACDLENISIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTA 624
             :.....|.......|:|.:.:|.||::|.||||..||.||::|.||:...|.||:|||::||||
  Rat   568 EEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTA 632

  Fly   625 NLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFT 689
            |||||||.|||::|||:|||||.||||:||||::|||..|||.|.|..::|:|..|.:.:||.|.
  Rat   633 NLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFV 697

  Fly   690 TTYEDGIKRV--NQGNYAFLMESTMLDYIVQR-DCNLTQIGGLLDTKGYGIATPKGSPWRDKISL 751
            .|.|:|:.||  ::|.||:|:||||.:||.|| .|:..::||.||:|||||||||||..|:.::|
  Rat   698 RTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNL 762

  Fly   752 AILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFF 816
            |:|:|.|:|.:..|.:|||.:..| |.......:.|.::|.|.::.|||.:||.|:.:|.:||..
  Rat   763 AVLKLNEQGLLDKLKNKWWYDKGE-CGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALI 826

  Fly   817 EFWYNFRYNYEATPSQSVVNNKYNQDGILESERNYTPPDRS 857
            ||.|..|...:......::    .|..|.|:.|..|.|..|
  Rat   827 EFCYKSRSESKRMKGFCLI----PQQSINEAIRTSTLPRNS 863

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.