DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ekar and grin2da

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	XP_009292354.1	Gene:	grin2da / 449864	ZFINID:	ZDB-GENE-041008-124	Length:	1916	Species:	Danio rerio

Alignment Length:	536	Identity:	146/536 - (27%)
Similarity:	258/536 - (48%)	Gaps:	107/536 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   326 EEENSWDGGLSLINYLNAVEWKGLTGPI--QFKDGQRVQFKLDLIKLKQHSIVKVGEWTPHGHLN 388
            ||...|:.|:..:.|   ..|... ||.  ...|.|.    |.::.|::...|
Zfish   422 EEVGWWENGVLRLRY---PPWSRY-GPFLKPLDDSQH----LRVVTLEERPFV------------ 466

  Fly   389 ITEPSMFFDAGS-------------MNVTLVVITILETPYVMMHYGKNFTGNERFYGFCVDILET 440
            |.||:   |.|:             :|.::||    |....|.|..|         |||:|:|:.
Zfish   467 IVEPA---DPGTGSCIRDSVPCRLPLNNSMVV----EGIQSMKHCCK---------GFCIDVLKR 515

  Fly   441 ISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTITYARESVIDFTKPFM 505
            :::.|||.|.|.||.:.::| |:.: |:|||||.:::..:||:|:||:||...|..|::|:.||:
Zfish   516 LAKIVGFTYDLYLVTNGRHG-KNID-GQWNGMVGEVVSKRADMAIGSLTINEERSEVVEFSVPFV 578

  Fly   506 NLGISILFKVP--TSEPTRLFSFMNPLAIEIWIYVLI-AYFLVSLCIYIVGKLSPIEWKCINACD 567
            ..|||::....  |..|:   :|:.|.:..:|:.:.: ...:|::.::|....||:.:
Zfish   579 ETGISVMVSRSNGTVSPS---AFLEPYSPAVWVMMFVMCLSVVAVTVFIFEFFSPVGY------- 633

  Fly   568 LENISI-------GNQFSLTDSFWFTIG-TFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTA 624
              |.|:       |::|::..|.|.... .|....|...||..:::|:...|.||::|.:|||||
Zfish   634 --NRSLQSGKTAGGSKFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTA 696

  Fly   625 NLAAFLTTERMINPIENAEDLASQ--TE----ISYGTLDSGSTMTFFRDSVIETYKKIWRSM--D 681
            |||||:..|..|:.:....|...|  ||    :.:||:.:|||    .:::...|..:.:.|  :
Zfish   697 NLAAFMIQEEYIDTVSGLSDKKFQHPTEQYPPLRFGTVPNGST----EENIRSNYPNMHQYMVRN 757

  Fly   682 NKKPSAFTTTYEDGIKRVNQGNY-AFLMESTMLDYIVQRD--CNLTQIGG--LLDTKGYGIATPK 741
            |::      ..||.|:.:..|.. ||:.::.:|:|:.::|  |.:..||.  :..|.|||:|..|
Zfish   758 NQR------GVEDAIENLKTGKLDAFIYDAAVLNYMARKDEGCKVMTIGSGKVFATTGYGVALHK 816

  Fly   742 GSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAG 806
            .|.|:..:.||:|:|....:|.||...|...   .|  .|...:..::.|.::::.|||.:|:..
Zfish   817 NSRWKRPLDLALLQLVGDDEIDMLERLWLSG---IC--HNDKIEVMSSKLDIDNMAGVFYMLLVA 876

  Fly   807 IIVAAVVAFFE---FW 819
            :.::.:|..:|   :|
Zfish   877 MGLSLLVFAWEHLVYW 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	13/63 (21%)
		ANF_receptor	39..371	CDD:279440	11/46 (24%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	118/392 (30%)
		Lig_chan	533..807	CDD:278489	79/295 (27%)
grin2da	XP_009292354.1	PBP1_iGluR_NMDA_NR2	42..441	CDD:107373	6/21 (29%)
		PBP2_iGluR_NMDA_Nr2	452..851	CDD:270436	128/459 (28%)
		HisJ	<507..>590	CDD:223904	35/84 (42%)
		Lig_chan	605..877	CDD:278489	79/295 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810