DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ekar and grid2

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_001004123.1	Gene:	grid2 / 448841	ZFINID:	ZDB-GENE-040913-1	Length:	1009	Species:	Danio rerio

Alignment Length:	911	Identity:	249/911 - (27%)
Similarity:	444/911 - (48%)	Gaps:	154/911 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLFQFLSYGLGVPP-----LVRIGAIFSNQPGMYNSELAFRYAIHRLNMDKSLLPETTVDYYVEY 67
            :||....:.|...|     ::.||||| ::....:.|: ||.|:..||::..:|....:...||:
Zfish     7 VLFLITFWSLEWEPVLPDSIIHIGAIF-DESAKKDDEV-FRMAVADLNLNNEILETEKITVSVEF 69

  Fly    68 VNRFDSFETVQKVCKLIRVGVQAVFSPTDSVLATHINSICDALDIPNI---------GRSA---- 119
            |:..:.|:.||:.|:|:..|:.|:.|....:.|..:.|:.||:.||::         .||:
Zfish    70 VDGNNPFQAVQEACELMNRGILALVSSIGCMSAGSLQSLADAMHIPHLFIQRAPAGTPRSSCPPT 134

  Fly   120 -----HDFSINVYPSKQLVNYAFNDVIQYLNWTRFGILHEKE---NGIIN-LHQLSRSFHGEVHM 175
                 .|:::.|.|...|.:..|..|::| .|.:|.|.::.:   .||.| |.|.|:
Zfish   135 TRAQPDDYTLFVRPPVYLNDVIFQVVMEY-TWQKFIIFYDTDYDIRGIENFLDQTSQ-------- 190

  Fly   176 RQVSRDSYVSALNEFKGKEIHNIIIDTNSN-GISILLKNILQQQMNEY----KYHYLFTS----- 230
                           :|.::....:::|.| .|:.:.:.:..::::.|    :...||.|
Zfish   191 ---------------QGMDVSLQKVESNINMMITGMFRTMRVEELHRYRDTLRRAVLFMSPATAK 240

  Fly   231 -FDLETYDLE----DFKYNFVNITSFRLVDTADVGVKQ-ILKDIG-------------------L 270
             |..|..:..    |.::..:|      .:.:|:.|:: ::|.||                   :
Zfish   241 AFITEVVETNLVAFDCQWIIIN------EEISDMDVQELVMKSIGRLTLVRQTFPLPQNTSQRCV 299

  Fly   271 YSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGL-QTLEQSHSLTLLNISCEEENS--WD 332
            .::|.......:....|:.:||.....::|:|.:.|... :.||.....::.::||..:.|  |.
Zfish   300 RNNHRINTSLCDPKDPKAQMLEITNRYIYDTVLLLANTFHRKLEDRKWHSMASLSCIRKGSKPWQ 364

  Fly   333 GGLSLINYLNAVEWKGLTGPIQFKD-GQRVQFKLDLI-----KLKQHSIVKVGEWTP-HGHLNIT 390
            ||.|::..:......|||..::|.| |.......:::     :.:...:.::..|.| || ||.|
Zfish   365 GGKSMLETVKKGGVSGLTSLLEFNDNGSNPNIHFEILGTNYGEDRGRGVSRLATWDPIHG-LNGT 428

  Fly   391 EPSMFFDAGSMNVTLVVITILETPYVMMHYGKNFTGN-ERFYGFCVDILETISREVGFDYILDLV 454
            ......:.....|.|.|:|:||.|:||:  .:|..|. :::.||.:|:|:.::..:||.|.:.:.
Zfish   429 LTDRKLENNMRGVVLRVVTVLEEPFVMV--SENVLGKPKKYQGFSIDVLDALANYLGFKYEIYVA 491

  Fly   455 PDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTITYARESVIDFTKPFMNLGISILFKVPTSE 519
            ||.|||::..: |.|||::.:|:..:||:.:.::|||..||||:|||..:|:..:.:|.: ....
Zfish   492 PDHKYGSQQAD-GTWNGLIGELVFKRADVGLSALTITPERESVVDFTTRYMDYSVGVLLR-KAER 554

  Fly   520 PTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEWKCINACDLENISIGNQFSLT--DS 582
            ...:|:.:.|..:.:|..:.....||...:|::..|:|           ..:.:|:..|.|  :|
Zfish   555 TVDMFACLAPFDLSLWACIAGTVLLVGTLVYLLNWLNP-----------PRLPMGSVSSTTLYNS 608

  Fly   583 FWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLAS 647
            .||..|:|:||..::....::||::...|..|:||:::|||||||||||..|:.|.|::.:|||.
Zfish   609 MWFVYGSFVQQGGEVPYTTLATRMMMGVWWLFALIVISSYTANLAAFLTISRIENSIQSLQDLAK 673

  Fly   648 QTEISYGT-LDSG--------STMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYE--DGIKRVNQ 701
            ||::.||| |||.        ....|.||.:   |.::|| |.|:...|.....|  :||::|..
Zfish   674 QTDLPYGTVLDSAVYDQVRSKGMNPFERDPM---YSQMWR-MINRTGGAENNVEESKEGIRKVKY 734

  Fly   702 GNYAFLMESTMLDYIV--QRDCNLTQIGGLLDTKGYGIATPKGSPWRDKISLAILELQERGDIQM 764
            |.:||:.::.:|:|:.  ..||:|..:...:..:|||:|...|||:||..|..|||||:.||:.:
Zfish   735 GRFAFVWDAAVLEYVAINDEDCSLYTVSNNVADRGYGMAMQHGSPYRDIFSQRILELQQNGDMDI 799

  Fly   765 LYDKWWKNTDETC-------TRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFEFWYNF 822
            |..|||.. |..|       |||:.|      :|.:.|..|||.||.||::::.::|..|.|:..
Zfish   800 LKLKWWPR-DSPCDLYSPVGTRKSGS------ALDIHSFAGVFFVLAAGVVLSCLIATVETWWTR 857

  Fly   823 R 823
            |
Zfish   858 R 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	90/430 (21%)
		ANF_receptor	39..371	CDD:279440	81/397 (20%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	132/384 (34%)
		Lig_chan	533..807	CDD:278489	103/295 (35%)
grid2	NP_001004123.1	PBP1_iGluR_delta_2	28..427	CDD:107386	91/431 (21%)
		ANF_receptor	42..404	CDD:279440	81/392 (21%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	132/384 (34%)
		Lig_chan	568..841	CDD:278489	102/294 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	989..1009
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.910