Protein Alignment Ekar and GluRIB

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_001261621.2
• Gene: GluRIB / 44484
• FlyBaseID: FBgn0264000
• Length: 1182
• Species: Drosophila melanogaster
• Alignment Length: 991
• Identity: 311/991 - (31%)
• Similarity: 502/991 - (50%)
• Gaps: 207/991 - (20%)

  Fly    16 GLGV---PPL---VRIGAIFSNQPGMYNSELAFRYAI--HRLNMDKSLLPETTVDYYVEYVNRFD 72
            |:||   |.|   :.:||||  :.|....:.||:||:  |.||:...   ...:..||:.:|..|
  Fly    29 GVGVSAQPSLTEKIPLGAIF--EQGTDEVQSAFKYAMLNHNLNVSSR---RFELQAYVDVINTAD 88

  Fly    73 SFETVQKVCKLIRVGVQAVF---SPTDSVLATHINSICDALDIPNI-----------GRSAHDFS 123
            :|:..:.:|.....||.::.   || ||....|  |..:...:|.:           .....||:
  Fly    89 AFKLSRLICNQFSRGVYSMLGAVSP-DSFDTLH--SYSNTFQMPFVTPWFPEKVLTPSSGFLDFA 150

  Fly   124 INVYPSKQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQL-------SRSFHGEVHMRQVSRD 181
            :::.|.   .:.|..|.||:..|.:...|::..:|::.|.|:       :.||..|:    |.|.
  Fly   151 LSMRPD---YHQAIIDTIQFYGWRKIIYLYDSHDGLLRLQQIYQGLRPGNESFQVEL----VKRI 208

  Fly   182 SYVSALNEFK------GK-EIHNIIIDTNSN-GISILLKNILQQQMNEYKYHYLFTSFDL-ETYD 237
            |.||...||.      |: |..:|::|..:. ...||::::...::....||||.:...: :.::
  Fly   209 SNVSMAIEFLHTLEQIGRFENKHIVLDCPTEMAKQILIQHVRDLRLGRRTYHYLLSGLVMDDRWE 273

  Fly   238 LEDFKYNFVNITSFRLVDTADVGVKQILKDIGLYSHHIFKK--PYLNLHIKKSTILESEPALMFD 300
            .|..::..:|||.||:|||.    ::::::.    :..:|:  |.:::...:.:| .::.|||:|
  Fly   274 SEIIEFGAINITGFRIVDTN----RRLVREF----YDSWKRLDPQMSVGAGRESI-SAQAALMYD 329

  Fly   301 SVYVFAIGLQTL-----------EQSHSLTLL--------------------------------- 321
            :|:|.......:           .|..|.||:
  Fly   330 AVFVLVEAFNKILRKKPDQFRNNVQRRSQTLMVAQAAASTSSDGYNYSASGGGGGNGGAGGGFAG 394

  Fly   322 ------------NISCEEE----NSWDGGLSLINYLNAVEWKGLTGPIQFK-DGQRVQFKLDLIK 369
                        .:.|...    |:|:.|..:..||..||.:||||.|:|. ||:||.:.|.:::
  Fly   395 SDSGGSGGMASRALDCNTAKGWVNAWEHGDKISRYLRKVEIEGLTGDIKFNDDGRRVNYTLHVVE 459

  Fly   370 LKQHS-IVKVGEWTPHGHLN-------ITEPSMFFDAGSMNVTLVVITILETPYVMMH---YGKN 423
            :..:| :|||.||.....|.       ...|.:.|:   .|.|.:|.|:||.||:|:.   :|:.
  Fly   460 MTVNSAMVKVAEWNDDAGLQPLNAKYVRLRPHVEFE---KNRTYIVTTVLEEPYIMLKQVAFGEK 521

  Fly   424 FTGNERFYGFCVDILETISREVGFDYILDLVPDRKYGA-KDPETGEWNGMVAQLMKYKADLAVGS 487
            ..||.||.|:|.|:.:.:::|:|.:|.|.||.|..||: |....|.|:|||.:|::.:||:|:.:
  Fly   522 LHGNNRFEGYCKDLADLLAKELGINYELRLVKDGNYGSEKSSAHGGWDGMVGELVRKEADIAIAA 586

  Fly   488 MTITYARESVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIV 552
            ||||..||.||||:||||:|||||:.|.|..:...:|||||||:.|||:.|:.:|..||:.::.|
  Fly   587 MTITAERERVIDFSKPFMSLGISIMIKKPVKQTPGVFSFMNPLSQEIWVSVIFSYIGVSIVLFFV 651

  Fly   553 GKLSPIEWKCI------------------------------------------------NACDLE 569
            .:.||.||:.:                                                .|..|:
  Fly   652 SRFSPHEWRLVQQQPQQSQSPDPHAHHEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAAALQ 716

  Fly   570 -------------NISIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLIIVAS 621
                         :.::.|:||:.:||||::..||||..|:.||::|.||.:::|.||:||:::|
  Fly   717 AALSAGSPGSGGSSSAVVNEFSVWNSFWFSLAAFMQQGCDLSPRSVSGRIAAASWFFFTLILISS 781

  Fly   622 YTANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNKKPS 686
            ||||||||||.|||:.||.:.||||.|||:.||||..|||..|||.|.|..:.|:|..|:::| .
  Fly   782 YTANLAAFLTVERMVTPINSPEDLAMQTEVQYGTLLHGSTWDFFRRSQIGLHNKMWEYMNSRK-H 845

  Fly   687 AFTTTYEDGIKRV--NQGNYAFLMESTMLDYIVQRD-CNLTQIGGLLDTKGYGIATPKGSPWRDK 748
            .|..||::|||||  ::|.||.|:||...:|:..|: |:..::|..|||||:|||||.||..:|.
  Fly   846 VFVPTYDEGIKRVRNSKGKYALLVESPKNEYVNAREPCDTMKVGRNLDTKGFGIATPLGSALKDP 910

  Fly   749 ISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVV 813
            |:||:|.|:|.|::..|.:|||....|..|.|:  .::..:.|.|.::.|:|.:||.|::|:..|
  Fly   911 INLAVLTLKENGELIKLRNKWWYEKAECSTHKD--GETSHSELSLSNVAGIFYILIGGLLVSVFV 973

  Fly   814 AFFEFWYNFRYNYEAT 829
            |..|:.:..|.:..|:
  Fly   974 AILEYCFRSRDSRSAS 989

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	107/468 (23%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	180/436 (41%)
		Lig_chan	532..806	CDD:459656	126/337 (37%)
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..480	CDD:380603	107/460 (23%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	181/441 (41%)
		Lig_chan	630..966	CDD:459656	126/338 (37%)