DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ekar and GluRIID

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster

Alignment Length:	873	Identity:	293/873 - (33%)
Similarity:	460/873 - (52%)	Gaps:	76/873 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 VRIGAIFSNQPGMYNSELAFRYAIHRLN--MDKSLLPETTVDYYVEYVNRFDSFETVQKVCKLIR 85
            :|:|.|..:.......  .|.:||..:|  :...|:.||.   .|.|.|...:|   .::|:|::
  Fly    34 IRLGLITDDATDRIRQ--TFEHAISVVNNELGVPLVGETE---QVAYGNSVQAF---AQLCRLMQ 90

  Fly    86 VGVQAVFSPTDSVLATHINSICDALDIPNI------GRSAHDFSINVYPSKQLVNYAFNDVIQYL 144
            .||.|||.|.....|:|:.:.||:.|||.|      |.:...|  |::||.:.:..|..|::...
  Fly    91 SGVGAVFGPAARHTASHLLNACDSKDIPFIYPHLSWGSNPDGF--NLHPSPEDIANALYDIVNQF 153

  Fly   145 NWTRFGILHEKENGIINLHQLSRSFHGEVHMRQVSR------DSYVSALNEFKGKEIHNIIIDTN 203
            .|:||...:|....:..|..|...:..:..:.:|.|      .:|.|.|...:..|...|::..:
  Fly   154 EWSRFIFCYESAEYLKILDHLMTRYGIKGPVIKVMRYDLNLNGNYKSVLRRIRKSEDSRIVVVGS 218

  Fly   204 SNGISILLKNILQQQMNEYKYHYLFTSFDLETYDLEDFKYNFVNITSFRLVDTADVGVKQILKDI 268
            :.|::.||:...|..:....|.|:..:.:|.|:|||::||:..|||..|:.......|:.:::.:
  Fly   219 TTGVAELLRQAQQVGIMNEDYTYIIGNLNLHTFDLEEYKYSEANITGIRMFSPDQEEVRDLMEKL 283

  Fly   269 GLYSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGLQTLEQSHSLTLLNISCEEENSWDG 333
               ...:.:...:|   ..||.:..|.||.:|:|.|  |...|....:...:||.|...:|....
  Fly   284 ---HQELGESEPVN---SGSTFITMEMALTYDAVRV--IAETTKHLPYQPQMLNCSERHDNVQPD 340

  Fly   334 GLSLINYLNAVE--WKGLTGPIQFKDGQRVQFKLDLIKLKQHSIVKVGEWTPHGHLNITEPSMF- 395
            |.:..||:.::|  .|.:||.|.|:...|..|..|:|:|:...:||||.|..........|...
  Fly   341 GSTFRNYMRSLEIKEKTITGRIYFEGNVRKGFTFDVIELQTSGLVKVGTWEEGKDFEFQRPPQAV 405

  Fly   396 ----FDAGSM-NVT-LVVITILETPYV-MMHYGKNFTGNERFYGFCVDILETISREVGFDYIL-D 452
                .|.||: |.| :|:|::...||. ::.......||.:|.|:.||:::.::.::||::.. |
  Fly   406 NFNDIDDGSLVNKTFIVLISVATKPYASLVESIDTLIGNNQFQGYGVDLIKELADKLGFNFTFRD 470

  Fly   453 LVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTITYARESVIDFTKPFMNLGISILFKVPT 517
            ...|  ||:.:..|...:||:.::::.:||||:..:|||..||.||||:.|||||||:||:..|.
  Fly   471 GGND--YGSFNKTTNSTSGMLKEIVEGRADLAITDLTITSEREEVIDFSIPFMNLGIAILYVKPQ 533

  Fly   518 SEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEWKCINACDLENISIGNQFSLTDS 582
            ..|..|||||:|.:.|:|:|:.|||..||||.:|:|:||||||.....|..|...:.|||::.:|
  Fly   534 KAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEWDNPYPCIEEPEELENQFTINNS 598

  Fly   583 FWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLA- 646
            .|||.|..:||..:|.|:|:|||.||:.|.||:||:|:|||||||||||.|...:||.:.:|||
  Fly   599 LWFTTGALLQQGSEIAPKALSTRTISAIWWFFTLIMVSSYTANLAAFLTIENPTSPINSVKDLAD 663

  Fly   647 SQTEISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYEDGIKRVNQG-NYAFLMES 710
            ::.::.||...:|||..||..|....|.|:...: |..|.......:.|:.:|..| .|||||||
  Fly   664 NKDDVQYGAKRTGSTRNFFSTSEEPIYIKMNEYL-NAHPEMLMENNQQGVDKVKSGTKYAFLMES 727

  Fly   711 TMLDYIVQRDCNLTQIGGLLDTKGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDE 775
            |.:::...|:||||::|..||.||||||..|..|:|||.:.|:|||||:|.:..|.:|||.....
  Fly   728 TSIEFNTVRECNLTKVGDPLDEKGYGIAMVKNWPYRDKFNKALLELQEQGVLARLKNKWWNEVGA 792

  Fly   776 -TCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFEFWYNFRYNYEATPSQSVVNNKY 839
             .|:.|  |.....:.||::::.|::|||:.|.|::.:::.. .|..|.|
  Fly   793 GVCSAK--SDDDGPSELGVDNLSGIYVVLVIGSIISIIISIL-CWCYFVY--------------- 839

  Fly   840 NQDGILESERNYTPPDRSFWIEIAEELR 867
                  :..:||..|   |...:|||.|
  Fly   840 ------KKAKNYEVP---FCDALAEEFR 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	102/379 (27%)
		ANF_receptor	39..371	CDD:279440	93/347 (27%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	164/373 (44%)
		Lig_chan	533..807	CDD:278489	123/276 (45%)
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	102/379 (27%)
		ANF_receptor	46..380	CDD:279440	93/351 (26%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	164/373 (44%)
		Lig_chan	549..819	CDD:278489	121/272 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462876
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.750