DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ekar and CG11155

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster

Alignment Length:	900	Identity:	484/900 - (53%)
Similarity:	632/900 - (70%)	Gaps:	48/900 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 IASGFLLFQFLSYGLGVPPLVRIGAIFSNQPGMYNSELAFRYAIHRLNMDKSLLPETTVDYYVEY 67
            |...:::...|.....:||::|:||||:......:.|.||:|||:|:|.:|:|||.|.:.|.:||
  Fly    23 ICCSYIILSILVISNALPPVIRVGAIFTEDERESSIESAFKYAIYRINKEKTLLPNTQLVYDIEY 87

  Fly    68 VNRFDSFETVQKVCKLIRVGVQAVFSPTDSVLATHINSICDALDIPNI-GR-----SAHDFSINV 126
            |.|.|||.|.:|||..:..||||:|.|||::||:|:.|||:|.|||:| ||     ::.:||||:
  Fly    88 VPRDDSFRTTKKVCSQLEAGVQAIFGPTDALLASHVQSICEAYDIPHIEGRIDLEYNSKEFSINL 152

  Fly   127 YPSKQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQLSRSFHGEVHMRQVSRDSYVSALNEFK 191
            |||..|:..|:.|::.|||||:..|::|::.|:.||...|.....|:::||.|.|||...|...:
  Fly   153 YPSHTLLTLAYRDIMVYLNWTKVAIIYEEDYGLFNLMHSSTETKAEMYIRQASPDSYRQVLRAIR 217

  Fly   192 GKEIHNIIIDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETYDLEDFKYNFVNITSFRLVDT 256
            .|||:.||:|||.:.|....::|||.|||:::|||:||:|||||||||||:||.||||:|||||.
  Fly   218 QKEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTFDLETYDLEDFRYNSVNITAFRLVDV 282

  Fly   257 ADVGVKQILKDIGLYSHH----IFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGLQ--TLEQS 315
            ......:::..:....|:    |...||          :::|.||||||||.||.||.  .|:..
  Fly   283 DSKRYLEVINQMQKLQHNGLDTINGSPY----------IQTESALMFDSVYAFANGLHFLNLDNH 337

  Fly   316 HSLTLLNISCEEENSWDGGLSLINYLNAVEWKGLTGPIQFKDGQRVQFKLDLIKLKQHSIVKVGE 380
            .:..:.|:||..:.:|:.|:||.|.:||....||||.:||.:|:|..||||::||||..|.|||.
  Fly   338 QNFYIKNLSCTSDQTWNDGISLYNQINAAITDGLTGTVQFVEGRRNIFKLDILKLKQEKIQKVGY 402

  Fly   381 WTPHGHLNITEPSMFFDAGSMNVTLVVITILETPYVMMHYGKNFTGNERFYGFCVDILETISREV 445
            |.|...:||::|:.|:|:...|:||||:|..|.||||:...||.|||.||.|||:|:|:.|:.:|
  Fly   403 WHPDDGVNISDPTAFYDSNIANITLVVMTREERPYVMVKEDKNLTGNLRFEGFCIDLLKAIATQV 467

  Fly   446 GFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTITYARESVIDFTKPFMNLGIS 510
            ||.|.::||||..||...|||..|||:|.:||:.:|||||.||||.||||||||||||||||||.
  Fly   468 GFQYKIELVPDNMYGVYIPETNSWNGIVQELMERRADLAVASMTINYARESVIDFTKPFMNLGIG 532

  Fly   511 ILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEWKCINACDLENISIGN 575
            ||||||||:||||||||||||||||:|||.||.|||..::::.:.||.|||..:.|..|...:.|
  Fly   533 ILFKVPTSQPTRLFSFMNPLAIEIWLYVLAAYILVSFALFVMARFSPYEWKNPHPCYKETDIVEN 597

  Fly   576 QFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERMINPIE 640
            |||:::||||..|||::|...:.|:|.||||:...|.||.|||::|||||||||||.||||:|||
  Fly   598 QFSISNSFWFITGTFLRQGSGLNPKATSTRIVGGCWFFFCLIIISSYTANLAAFLTVERMISPIE 662

  Fly   641 NAEDLASQTEISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYEDGIKRVNQGNYA 705
            :|.|||.|||||||||:.||||||||||.|..|:|:||.|:|:|.:.|..|||||||||.:|:||
  Fly   663 SASDLAEQTEISYGTLEGGSTMTFFRDSKIGIYQKMWRYMENRKTAVFVKTYEDGIKRVMEGSYA 727

  Fly   706 FLMESTMLDYIVQRDCNLTQIGGLLDTKGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWW 770
            ||||||||||.|||||||||||||||:||||||||||||||||||||||||||:|.||:||||||
  Fly   728 FLMESTMLDYAVQRDCNLTQIGGLLDSKGYGIATPKGSPWRDKISLAILELQEKGIIQILYDKWW 792

  Fly   771 KNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFEFWYNFRYNYEATPSQSVV 835
            |||.:.|.|.:.||:||||:||:|:||||||||:.|:.:|.|||.|||.:|.|.|.. |.:||:.
  Fly   793 KNTGDVCNRDDKSKESKANALGVENIGGVFVVLLCGLALAVVVAIFEFCWNSRKNLN-TENQSLC 856

  Fly   836 NNKYNQDGILESERNYTPPDRSFWIEIAEELRYASWCM-NKQKRPALTRTCSKCT 889
            :                        |:|||||:|..|. :|.:.....|:|..|:
  Fly   857 S------------------------EMAEELRFAMHCHGSKSRHRPRKRSCLNCS 887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	172/375 (46%)
		ANF_receptor	39..371	CDD:279440	158/343 (46%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	254/368 (69%)
		Lig_chan	533..807	CDD:278489	186/273 (68%)
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	172/375 (46%)
		ANF_receptor	61..393	CDD:279440	157/341 (46%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	254/368 (69%)
		Lig_chan	555..829	CDD:278489	186/273 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45470674
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	1	1.000	-	-		H68992
Inparanoid	1	1.050	164	1.000	Inparanoid score	I1601
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	11	10.800