DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ekar and KaiR1D

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster

Alignment Length:	857	Identity:	353/857 - (41%)
Similarity:	526/857 - (61%)	Gaps:	57/857 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ASGFLLFQFLSYGL--------GVPPLVRIGAIFSNQPGMYNSELAFRYAIHRLNMDKSLLPETT 60
            :||.|:...|...|        .:|.:::||.:|  .|...:.|||||.|:.|:|.|:|:||.:.
  Fly     3 SSGVLVLPLLLLQLILNCRKAQSLPDIIKIGGLF--HPADDHQELAFRQAVDRINADRSILPRSK 65

  Fly    61 VDYYVEYVNRFDSFETVQKVCKLIRVGVQAVFSPTDSVLATHINSICDALDIPNIGRSAHDFS-- 123
            :...:|.::.||||...::||.|:.:||.|:|.|..|..|:|:.||||.::||:: .:..|:.
  Fly    66 LVAQIERISPFDSFHAGKRVCGLLNIGVAAIFGPQSSHTASHVQSICDNMEIPHL-ENRWDYRLR 129

  Fly   124 -----INVYPSKQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQLSRSFHG----EVHMRQVS 179
                 :|:||....::.|:.|::::..|..|.|::|..:||:.|.:|.:: ||    .:.:||:|
  Fly   130 RESCLVNLYPHPNTLSKAYVDIVRHWGWKTFTIIYENNDGIVRLQELLKA-HGMTPFPITVRQLS 193

  Fly   180 RDS--YVSALNEFKGKEIHNIIIDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETYDLEDFK 242
             ||  |...|.:.|.....:|::|.::..|..:||...|..|....:.||.||.||.|.:|::|:
  Fly   194 -DSGDYRPLLKQIKNSAEAHIVLDCSTERIHEVLKQAQQIGMMSDYHSYLVTSLDLHTVNLDEFR 257

  Fly   243 YNFVNITSFRLVD---TADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESEPALMFDSVYV 304
            |...|||.|||::   .:||..:..:.:.||            |.....|.:.||.|||:|:|::
  Fly   258 YGGTNITGFRLINEKIVSDVVRQWSIDEKGL------------LRSANLTTVRSETALMYDAVHL 310

  Fly   305 FAIGLQTLEQSHSLTLLNISCEEENSWDGGLSLINYLNAVEWKGLTGPIQF-KDGQRVQFKLDLI 368
            ||..|..|:.|..:.:..|||:.:::|..|.|||||:..||.||||..|:| ..|.|..|.||::
  Fly   311 FAKALHDLDTSQQIDIHPISCDGQSTWQHGFSLINYMKIVEMKGLTNVIKFDHQGFRTDFMLDIV 375

  Fly   369 KLKQHSIVKVGEWT---PHGHLNIT----EPSMFFDAGSMNVTLVVITILETPYVMMHYGK-NFT 425
            :|....|.|:|.|.   |.| :|.|    :.....:|...|.||||.|||..||.|..... ..:
  Fly   376 ELTPAGIRKIGTWNSTLPDG-INFTRTFSQKQQEIEANLKNKTLVVTTILSNPYCMRKESAIPLS 439

  Fly   426 GNERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTI 490
            ||::|.|:.||::..||:.:||:|.:.||||..||:.:..|||||||:.:|::.:||||:..:||
  Fly   440 GNDQFEGYAVDLIHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQRADLAIADLTI 504

  Fly   491 TYARESVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKL 555
            |:.||..:|||.||||||:|||::.|..:|..||||::||::::|||:..||..||:.::|:.|.
  Fly   505 TFEREQAVDFTTPFMNLGVSILYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILAKF 569

  Fly   556 SPIEWKCINACDLENISIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLIIVA 620
            :|.||....  |.....:.:||:|.:..||.||:.|||..|..|:|:|||:::..|.||:||:::
  Fly   570 TPYEWPAYT--DAHGEKVESQFTLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGIWWFFTLIMIS 632

  Fly   621 SYTANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNKKP 685
            |||||||||||.|||.:|||:|||||.||.|.||.|..|||..|||||.|.||:::|..|::.:|
  Fly   633 SYTANLAAFLTVERMDSPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKISTYQRMWSFMESARP 697

  Fly   686 SAFTTTYEDGIKRV--NQGNYAFLMESTMLDYIVQRDCNLTQIGGLLDTKGYGIATPKGSPWRDK 748
            |.||.:..:|::||  .:|:||||||||.::|:.:|:|.|||:||:||||.||||||..||:|..
  Fly   698 SVFTASNGEGVERVAKGKGSYAFLMESTSIEYVTERNCELTQVGGMLDTKSYGIATPPNSPYRTA 762

  Fly   749 ISLAILELQERGDIQMLYDKWWKNT--DETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAA 811
            |:..||:|||.|.:.:|..||||..  ...|..:.:...|.||.|||.::|||||||:.|:.||.
  Fly   763 INSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFVVLMGGMGVAC 827

  Fly   812 VVAFFEFWYNFR 823
            |:|..||.:..|
  Fly   828 VIAVCEFVWKSR 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	133/383 (35%)
		ANF_receptor	39..371	CDD:279440	122/348 (35%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	187/371 (50%)
		Lig_chan	533..807	CDD:278489	138/277 (50%)
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	133/383 (35%)
		ANF_receptor	42..378	CDD:279440	122/350 (35%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	187/371 (50%)
		Lig_chan	547..823	CDD:278489	138/277 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	495	1.000	Inparanoid score	I765
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.870