DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ekar and Ir93a

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster

Alignment Length:	778	Identity:	151/778 - (19%)
Similarity:	285/778 - (36%)	Gaps:	210/778 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 GKEIHNIIIDTNSNGI------------------SILLKNILQQQMNEYKYHYLFTSFDLETYDL 238
            |.|...:|:|.....|                  ::|:|:|:.:.:..:     .|...|..|::
  Fly   145 GDEFPQLILDAKVQQILNWKTAVVFVDQTILEENALLVKSIVHESITNH-----ITPISLILYEI 204

  Fly   239 EDFKYNFVNITSFRLVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILE-SEPALMFD-- 300
            .|         |.| .....|.::|.|.......|...::.:|.:......|:| :|...||.
  Fly   205 ND---------SLR-GQQKRVALRQALSQFAPKKHEEMRQQFLVISAFHEDIIEIAETLNMFHVG 259

  Fly   301 ---SVYV-------FAIGLQTLEQSH--------------------------SLTLLN----ISC 325
               .::|       |..|..|:....                          ||.|:|    |:.
  Fly   260 NQWMIFVLDMVARDFDAGTVTINLDEGANIAFALNETDPNCQDSLNCTISEISLALVNAISKITV 324

  Fly   326 EEENSWDGGLSLINYLNAVEWKGLTGPIQFKDGQRVQFKLDLIKL-------------------- 370
            |||       |:...::..||:.:....|.|..:.:::..:.:|.
  Fly   325 EEE-------SIYGEISDEEWEAIRFTKQEKQAEILEYMKEFLKTNAKCSSCARWRVETAITWGK 382

  Fly   371 -----------------KQHSIVKVGEWTPHGHLNITEPSMFF---DAGSMNVTLVVITILETPY 415
                             :....:.:|.|||  .|......:.|   :....|:|:.::|:...|:
  Fly   383 SQENRKFRSTPQRDAKNRNFEFINIGYWTP--VLGFVCQELAFPHIEHHFRNITMDILTVHNPPW 445

  Fly   416 VMMHYGKNFTGNERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEW---NGMVAQLM 477
            .::....|....|. .|..::|::.:||.:.|.|.|.            |...|   :.:.....
  Fly   446 QILTKNSNGVIVEH-KGIVMEIVKELSRALNFSYYLH------------EASAWKEEDSLSTSAG 497

  Fly   478 KYKADLAVGSMT--ITYARESVI----------------------DFTKPFMNLGISILFKVPTS 518
            ..::|..|||||  |.|....::                      ::|:|......|.:.:.| .
  Fly   498 GNESDELVGSMTFRIPYRVVEMVQGNQFFIAAVAATVEDPDQKPFNYTQPISVQKYSFITRKP-D 561

  Fly   519 EPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEWKCINACDLENISIGNQFSLTDSF 583
            |.:|::.|..|..:|.|..::....|.:..:|.:.:|:|          |:.:.|....::...|
  Fly   562 EVSRIYLFTAPFTVETWFCLMGIILLTAPTLYAINRLAP----------LKEMRIVGLSTVKSCF 616

  Fly   584 WFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERM------INPIENA 642
            |:..|..:||.....|.|.|.|::...|....:::|.:|..||.||||..:.      :|.:|:.
  Fly   617 WYIFGALLQQGGMYLPTADSGRLVVGFWWIVVIVLVTTYCGNLVAFLTFPKFQPGVDYLNQLEDH 681

  Fly   643 EDLASQTEISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYEDGIKRVNQGNYAFL 707
            :|:     :.|| |.:|   |||...|..|.::.::.. .::...:.:..|:.|:.|.:|....:
  Fly   682 KDI-----VQYG-LRNG---TFFERYVQSTTREDFKHY-LERAKIYGSAQEEDIEAVKRGERINI 736

  Fly   708 MESTMLDYIVQR------DCNLTQIG--GLLDTKGYGIATPKGSPWRDKISLAILELQERGDIQM 764
            .....|..||||      :|:.. :|  ..:|.: ..:..|..|.:...::..|..:...|.|
  Fly   737 DWRINLQLIVQRHFEREKECHFA-LGRESFVDEQ-IAMIVPAQSAYLHLVNRHIKSMFRMGFI-- 797

  Fly   765 LYDKWWK-NTDET--CTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFEFWY-NFR 823
              ::|.: |....  |..|:..:|...:.:.::.:.|.|:||:.|..:|.::...|||| .||
  Fly   798 --ERWHQMNLPSAGKCNGKSAQRQVTNHKVNMDDMQGCFLVLLLGFTLALLIVCGEFWYRRFR 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	46/293 (16%)
		ANF_receptor	39..371	CDD:279440	42/276 (15%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	87/409 (21%)
		Lig_chan	533..807	CDD:278489	64/290 (22%)
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	67/300 (22%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	62/285 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462924
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940