DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ekar and Nmdar1

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster

Alignment Length:	969	Identity:	251/969 - (25%)
Similarity:	427/969 - (44%)	Gaps:	170/969 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 PPLVRIGAIFSNQPGMYNSELAFRYAIHRLNMDKSLLPETTVDYYVEYVNRFDS--FETVQKVC- 81
            |....||.:.||.    :||..|...|..||.|:..:|. .|.||.:.: |.|.  .:||..||
  Fly    36 PSTYNIGGVLSNS----DSEEHFSTTIKHLNFDQQYVPR-KVTYYDKTI-RMDKNPIKTVFNVCD 94

  Fly    82 KLIRVGVQAVFSPTDSVLATHINSICDA-----------LDIPNIGRSAHDFSI---NVYPS--K 130
            |||...|.|       |:.:|..:..|.           ..||.||.|:.|.:.   |::.|  :
  Fly    95 KLIENRVYA-------VVVSHEQTSGDLSPAAVSYTSGFYSIPVIGISSRDAAFSDKNIHVSFLR 152

  Fly   131 QLVNY-----AFNDVIQYLNWTRFGILHEKE---NGIINLHQ-LSRSFHGEVHMRQVSRDSYVSA 186
            .:..|     .:.:::.:..:|:..|:|..:   ..|:...| .|::::.:|.:|     :.|..
  Fly   153 TVPPYYHQADVWLEMLSHFAYTKVIIIHSSDTDGRAILGRFQTTSQTYYDDVDVR-----ATVEL 212

  Fly   187 LNEFKGKEIHNIIIDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETYDLEDFKYNFVNITSF 251
            :.||:.|             :....::::..:..:.:.:.::.|       .||.:..|.:...:
  Fly   213 IVEFEPK-------------LESFTEHLIDMKTAQSRVYLMYAS-------TEDAQVIFRDAGEY 257

  Fly   252 RLVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGLQTLEQSH 316
            .:.....|   .|:.:..|:|::. ....|.|.::.:   .|:...:.|||||.|..::.:..:.
  Fly   258 NMTGEGHV---WIVTEQALFSNNT-PDGVLGLQLEHA---HSDKGHIRDSVYVLASAIKEMISNE 315

  Fly   317 SLTLLNISC-EEENSWDGGLSLINYLNAVEWKGLTGPIQFKD-GQRVQFKLDLIKL----KQHSI 375
            ::......| :...:|:.|..|..||.:....|.||.:.|.| |.|:....|:|.:    |:|.:
  Fly   316 TIAEAPKDCGDSAVNWESGKRLFQYLKSRNITGETGQVAFDDNGDRIYAGYDVINIREQQKKHVV 380

  Fly   376 VKVG--EWTPHGHLNITEPSMFFDA-------GSMNVT-LVVITILETPYVM------------- 417
            .|..  .......:.|.:..:.:..       |.|..| |.::||.|.|:|.
  Fly   381 GKFSYDSMRAKMRMRINDSEIIWPGKQRRKPEGIMIPTHLRLLTIEEKPFVYVRRMGDDEFRCEP 445

  Fly   418 ------MHYGKNFTGNERF--YGFCVDILETISREVGFDYILDLVPDRKYG--AKDPETG----- 467
                  :....:.|.|| |  .|:|:|:|..:|:.:.|.|.|.|.||.::|  .....||
  Fly   446 DERPCPLFNNSDATANE-FCCRGYCIDLLIELSKRINFTYDLALSPDGQFGHYILRNNTGAMTLR 509

  Fly   468 -EWNGMVAQLMKYKADLAVGSMTITYARESVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLA 531
             ||.|::.:|:..:||:.|..:||...|...|:|:|||...||:||.|.|:...| |.||:.|.:
  Fly   510 KEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFKYQGITILEKKPSRSST-LVSFLQPFS 573

  Fly   532 IEIWIYVLIAYFLVSLCIYIVGKLSPI-EWKCINACDLENISIGNQFSLTDSFWFTIGTFMQQS- 594
            ..:||.|:::..:|:|.:|::.:.||. .:|..::...|..::    :|:.:.||..|..:...
  Fly   574 NTLWILVMVSVHVVALVLYLLDRFSPFGRFKLSHSDSNEEKAL----NLSSAVWFAWGVLLNSGI 634

  Fly   595 PDIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTER---MINPIENAEDLASQTEISYGTL 656
            .:..||:.|.|::...|..|::||||||||||||||..||   .::.|.:|....:...::..|:
  Fly   635 GEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLSGINDARLRNTMENLTCATV 699

  Fly   657 DSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYEDGIKRVNQGN-YAFLMESTMLDYIVQRD 720
            ...|...:||..|  ....::|:|:...    ..|.|..|:.|.:|. .||:.:|:.|:|...:|
  Fly   700 KGSSVDMYFRRQV--ELSNMYRTMEANN----YATAEQAIQDVKKGKLMAFIWDSSRLEYEASKD 758

  Fly   721 CNLTQIGGLLDTKGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWW---KNTDETCTRKNT 782
            |.|...|.|....||||...|||||.|.::|||||..|.|.::.| ||.|   .:..:.|    .
  Fly   759 CELVTAGELFGRSGYGIGLQKGSPWTDAVTLAILEFHESGFMEKL-DKQWIFHGHVQQNC----E 818

  Fly   783 SKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFEFWYNFRYNYEATPSQSVVNNKYNQDGILES 847
            ..:...|:|||:::.|||:::..||.....:...|..|.              .::..:...|:.
  Fly   819 LFEKTPNTLGLKNMAGVFILVGVGIAGGVGLIIIEVIYK--------------KHQVKKQKRLDI 869

  Fly   848 ERNYTPPDRSFWIEIAEELRYASWCMNKQKRPALTRTCSKCTI---------PK-GQRI 896
            .|:.....|. .||..:.:| ||..|.:|....|..|.:..||         |: |||:
  Fly   870 ARHAADKWRG-TIEKRKTIR-ASLAMQRQYNVGLNSTHAPGTISLAVDKRRYPRLGQRL 926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	85/399 (21%)
		ANF_receptor	39..371	CDD:279440	77/365 (21%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	132/407 (32%)
		Lig_chan	533..807	CDD:278489	89/282 (32%)
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	87/413 (21%)
		ANF_receptor	58..371	CDD:279440	75/353 (21%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	133/417 (32%)
		HisJ	451..>558	CDD:223904	37/107 (35%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	41/139 (29%)
		Lig_chan	575..838	CDD:278489	89/277 (32%)
		CaM_bdg_C0	854..882	CDD:287524	4/42 (10%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45463114
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.940