DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ekar and gria1b

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_991293.1	Gene:	gria1b / 403044	ZFINID:	ZDB-GENE-020125-2	Length:	917	Species:	Danio rerio

Alignment Length:	894	Identity:	309/894 - (34%)
Similarity:	473/894 - (52%)	Gaps:	112/894 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLIASGFLLFQFLSYGL----GVPPLVRIGAIFSNQPGMYNSELAFRYAIHRLNMDKSLLPETTV 61
            :|:.:|.|       ||    ..|..:.||.:|......|:   .||:|:.:.|....|:|:
Zfish     6 VLLLTGLL-------GLCSCSSFPSNINIGGLFPTDSHEYD---VFRFALSQHNDVPKLVPQ--- 57

  Fly    62 DYYVEYVNRFDSFETVQKVCKLIRVGVQAVFSPTDSVLATHINSICDALDIPNIGRS-----AHD 121
               |:.|:...||......|.....||.|:....|......:.|.|.||.:..:..|     .:.
Zfish    58 ---VDMVDTGSSFAMTYAFCSQFSKGVYAIIGLYDRKTMNMLMSFCGALHVCFVTPSFPIDTNNQ 119

  Fly   122 FSINVYPSKQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQL-----SRSFH-GEVHMRQVSR 180
            |.|.:.|..|   .|...::::..|.:|..::..::|:..|.::     .:::. ..::...::.
Zfish   120 FVIQLRPELQ---DALIALVEHYKWNKFVYMYSSDSGLTVLQKILDTAAEKTWQVTSINFDTLTE 181

  Fly   181 DSYVSALNEFKGKEIHNIIIDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETYDLEDFKYNF 245
            .:::.|:.:...|:...||:|.....::.:|..|..|:.|...|||:..:......:|.:|:...
Zfish   182 AAFLKAIQDLDNKKEFKIILDCELERLNSILNLIAAQKKNLKNYHYILANLGFLDLNLTEFRKGG 246

  Fly   246 VNITSFRLVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGLQ 310
            .|:|.|:|::..:..|.:.::|...:.....|.|      |:.  |:...||.:|.|.|.|...|
Zfish   247 ANVTGFQLMNYTNPTVSRTIQDWLEFDSKDLKSP------KRR--LKYTGALTYDGVTVMATAFQ 303

  Fly   311 TLEQSHSLTLLNIS---------CEEENSWDGGLSLINYLNAVEWKGLTGPIQFKD-GQRVQFKL 365
            .|.:..    ::||         ......|..|:.:...|..|:::||||.:||.| |.|..|.:
Zfish   304 NLRKQR----IDISRRGNAGECLANPPAPWGQGIDIQRALQQVQFEGLTGHVQFNDKGHRTNFTV 364

  Fly   366 DLIKLKQHSIVKVGEW----------TPHGHLNITEPSMFFDAGSMNVTLVVITILETPYVMMHY 420
            .:::.......|||.|          |....||.|       .|..|.|.||.||||.||||:.
Zfish   365 SVMEFGPSGPKKVGYWNQREKYVSTATYSNMLNET-------FGLQNRTYVVTTILEAPYVMLK- 421

  Fly   421 GKN---FTGNERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKAD 482
             ||   ..||:::.|:||::...|::.||:.|.|:||.|.||||:|.||..|||||.:|:..|||
Zfish   422 -KNHEQLVGNDKYEGYCVELAAEIAKHVGYSYRLELVGDGKYGARDAETMMWNGMVGELVYGKAD 485

  Fly   483 LAVGSMTITYARESVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSL 547
            :||..:|||..||.||||:||||:|||||:.|.||.....:|||::|||.|||:.::.||..||:
Zfish   486 VAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPTKSKPGVFSFLDPLAYEIWMCIVFAYIGVSV 550

  Fly   548 CIYIVGKLSPIEWKCIN---ACDLENIS---------------------------IGNQFSLTDS 582
            .:::|.:.||.||...:   ..|.:|.:                           ..|:|.:.:|
Zfish   551 VLFLVSRFSPYEWHADDEEETADQQNQNQPPSPEPNQSPNQSQNQREEKQEKQPEHTNEFGIFNS 615

  Fly   583 FWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLAS 647
            .||::|.||||..||.||::|.||:...|.||:|||::|||||||||||.|||::|||:|||||.
Zfish   616 LWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAK 680

  Fly   648 QTEISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYEDGIKRV--NQGNYAFLMES 710
            ||||:|||||.|||..|||.|.|..::|:|..|.:.:|:.|..|.::|:.||  ::|.||:|:||
Zfish   681 QTEIAYGTLDGGSTKEFFRRSKIAVFEKMWSYMKSAEPTVFVKTTDEGVVRVRKSKGKYAYLLES 745

  Fly   711 TMLDYIVQR-DCNLTQIGGLLDTKGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTD 774
            ||.:||.|| .|:..::||.||:||||:||||||..|:.::||:|:|.|:|.:..|.:|||.:..
Zfish   746 TMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKG 810

  Fly   775 ETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFEFWYNFR 823
            | |.......:.|.::|.|.::.|||.:||.|:.:|.:||..||.|..|
Zfish   811 E-CGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALVEFCYKSR 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	86/394 (22%)
		ANF_receptor	39..371	CDD:279440	77/352 (22%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	194/404 (48%)
		Lig_chan	533..807	CDD:278489	133/306 (43%)
gria1b	NP_991293.1	PBP1_iGluR_AMPA_GluR1	26..387	CDD:107385	85/384 (22%)
		ANF_receptor	41..368	CDD:279440	77/347 (22%)
		PBP2_iGluR_AMPA_GluR1	404..812	CDD:270447	196/410 (48%)
		Lig_chan	536..842	CDD:278489	133/306 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591504
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.640