Protein Alignment Ekar and Ir40a

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_610140.4
• Gene: Ir40a / 35449
• FlyBaseID: FBgn0259683
• Length: 732
• Species: Drosophila melanogaster
• Alignment Length: 702
• Identity: 138/702 - (19%)
• Similarity: 248/702 - (35%)
• Gaps: 166/702 - (23%)

  Fly   255 DTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGLQTLEQSH--- 316
            ||| :.:.||::.:...|..|...|.|.|   ...:.:.|..:..|..      ||.|.:|:
  Fly    31 DTA-IALTQIVRGLQQSSLAILALPSLAL---SDGVCQKERNVYLDDF------LQRLHRSNYKS 85

  Fly   317 ---SLTLLNISCEEENSWDGG-------------------------LSLINYLNAVEWKGLTGPI 353
               |.|.|.....|||.....                         |||..:.....|...:..|
  Fly    86 VVFSQTELFFQHIEENLQGANECISLILDEPNQLLNSLHDRHLGHRLSLFIFYWGARWPPSSRVI 150

  Fly   354 QFKDGQRV---------QFKLDLIKLK--QHSIVKVGEWTPHGHLNI-------TEPSMFFDAGS 400
            :|::..||         .|::...:.:  ..|.:::..|....:|.:       |..|::  |..
  Fly   151 RFREPLRVVVVTRPRKKAFRIYYNQARPCSDSQLQLVNWYDGDNLGLQRIPLLPTALSVY--ANF 213

  Fly   401 MNVTLVVITILETPYVMMHYGKN-FTGNERFYGFCVDILE----------------TISREVGFD 448
            ...|..|......|:..:.|..| |..:|.|..  :|.:|                .:|:.:.|.
  Fly   214 KGRTFRVPVFHSPPWFWVTYCNNSFEEDEEFNS--LDSIEKRKVRVTGGRDHRLLMLLSKHMNFR 276

  Fly   449 YILDLVPDRKYGAKDPETGE-----WNGMVAQLMKYKADLAVGSMTITYARESVIDFTKPFMNLG 508
            :.....|.|..|:...|.|:     :.|.:..|...:||..:|.:.:::.|...|:|:  |..|.
  Fly   277 FKYIEAPGRTQGSMRSEDGKDSNDSFTGGIGLLQSGQADFFLGDVGLSWERRKAIEFS--FFTLA 339

  Fly   509 ISILFKVPTSEPTRL---FSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEW--KCINACDL 568
            .|..|  .|..|.||   .:.|.|...:||.::::.........|.:..| |..|  :..|: |:
  Fly   340 DSGAF--ATHAPRRLNEALAIMRPFKQDIWPHLILTIIFSGPIFYGIIAL-PYIWRRRWANS-DV 400

  Fly   569 ENI-----------------------------SIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMST 604
            |::                             .:.:|. .....|||:..|::||.:........
  Fly   401 EHLGELYIHMTYLKEITPRLLKLKPRTVLSAHQMPHQL-FQKCIWFTLRLFLKQSCNELHNGYRA 464

  Fly   605 RIISSTWGFFSLIIVAS-YTANLAAFLTTERMINPIENAEDL------------ASQTEISYGTL 656
            :.::..:...:..::|. |:|.|.:.........||...:.|            ..:...|...|
  Fly   465 KFLTIVYWIAATYVLADVYSAQLTSQFARPAREPPINTLQRLQAAMIHDGYRLYVEKESSSLEML 529

  Fly   657 DSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYEDGIKRVNQG--NYAFL-MESTMLDYIVQ 718
            ::|:.:  ||    :.|..:.:.:.|.....|..:.|.|||.:.:|  :.|.| ...|:...:.|
  Fly   530 ENGTEL--FR----QLYALMRQQVINDPQGFFIDSVEAGIKLIAEGGEDKAVLGGRETLFFNVQQ 588

  Fly   719 RDCNLTQIGGLLDTKGYGIATPKGSPWRDKISLAILELQERGDIQML----YDKWWKNTDET--- 776
            ...|..|:...|.|:...:|...|.|:...::..:::|.|.|.:..:    |.|.::..:.|
  Fly   589 YGSNNFQLSQKLYTRYSAVAVQIGCPFLGSLNNVLMQLFESGILDKMTAAEYAKQYQEVEATRIY 653

  Fly   777 ---CTRKNTSKQSKANS--------LGLESIGGVFVVLIAGIIVAAVVAFFE 817
               ...||:...|:..|        |.|..:.|.|:.|..|.:.|.|:...|
  Fly   654 KGSVQAKNSEAYSRTESYDSTVISPLNLRMLQGAFIALGVGSLAAGVILLLE 705

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	34/183 (19%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	87/444 (20%)
		Lig_chan	532..806	CDD:459656	62/338 (18%)
Ir40a	NP_610140.4	Lig_chan-Glu_bd	<265..336	CDD:463166	15/72 (21%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:473866	23/98 (23%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:473866	30/146 (21%)