DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ekar and Ir40a

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_610140.4	Gene:	Ir40a / 35449	FlyBaseID:	FBgn0259683	Length:	732	Species:	Drosophila melanogaster

Alignment Length:	702	Identity:	138/702 - (19%)
Similarity:	248/702 - (35%)	Gaps:	166/702 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   255 DTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGLQTLEQSH--- 316
            ||| :.:.||::.:...|..|...|.|.|   ...:.:.|..:..|..      ||.|.:|:
  Fly    31 DTA-IALTQIVRGLQQSSLAILALPSLAL---SDGVCQKERNVYLDDF------LQRLHRSNYKS 85

  Fly   317 ---SLTLLNISCEEENSWDGG-------------------------LSLINYLNAVEWKGLTGPI 353
               |.|.|.....|||.....                         |||..:.....|...:..|
  Fly    86 VVFSQTELFFQHIEENLQGANECISLILDEPNQLLNSLHDRHLGHRLSLFIFYWGARWPPSSRVI 150

  Fly   354 QFKDGQRV---------QFKLDLIKLK--QHSIVKVGEWTPHGHLNI-------TEPSMFFDAGS 400
            :|::..||         .|::...:.:  ..|.:::..|....:|.:       |..|::  |..
  Fly   151 RFREPLRVVVVTRPRKKAFRIYYNQARPCSDSQLQLVNWYDGDNLGLQRIPLLPTALSVY--ANF 213

  Fly   401 MNVTLVVITILETPYVMMHYGKN-FTGNERFYGFCVDILE----------------TISREVGFD 448
            ...|..|......|:..:.|..| |..:|.|..  :|.:|                .:|:.:.|.
  Fly   214 KGRTFRVPVFHSPPWFWVTYCNNSFEEDEEFNS--LDSIEKRKVRVTGGRDHRLLMLLSKHMNFR 276

  Fly   449 YILDLVPDRKYGAKDPETGE-----WNGMVAQLMKYKADLAVGSMTITYARESVIDFTKPFMNLG 508
            :.....|.|..|:...|.|:     :.|.:..|...:||..:|.:.:::.|...|:|:  |..|.
  Fly   277 FKYIEAPGRTQGSMRSEDGKDSNDSFTGGIGLLQSGQADFFLGDVGLSWERRKAIEFS--FFTLA 339

  Fly   509 ISILFKVPTSEPTRL---FSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEW--KCINACDL 568
            .|..|  .|..|.||   .:.|.|...:||.::::.........|.:..| |..|  :..|: |:
  Fly   340 DSGAF--ATHAPRRLNEALAIMRPFKQDIWPHLILTIIFSGPIFYGIIAL-PYIWRRRWANS-DV 400

  Fly   569 ENI-----------------------------SIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMST 604
            |::                             .:.:|. .....|||:..|::||.:........
  Fly   401 EHLGELYIHMTYLKEITPRLLKLKPRTVLSAHQMPHQL-FQKCIWFTLRLFLKQSCNELHNGYRA 464

  Fly   605 RIISSTWGFFSLIIVAS-YTANLAAFLTTERMINPIENAEDL------------ASQTEISYGTL 656
            :.::..:...:..::|. |:|.|.:.........||...:.|            ..:...|...|
  Fly   465 KFLTIVYWIAATYVLADVYSAQLTSQFARPAREPPINTLQRLQAAMIHDGYRLYVEKESSSLEML 529

  Fly   657 DSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYEDGIKRVNQG--NYAFL-MESTMLDYIVQ 718
            ::|:.:  ||    :.|..:.:.:.|.....|..:.|.|||.:.:|  :.|.| ...|:...:.|
  Fly   530 ENGTEL--FR----QLYALMRQQVINDPQGFFIDSVEAGIKLIAEGGEDKAVLGGRETLFFNVQQ 588

  Fly   719 RDCNLTQIGGLLDTKGYGIATPKGSPWRDKISLAILELQERGDIQML----YDKWWKNTDET--- 776
            ...|..|:...|.|:...:|...|.|:...::..:::|.|.|.:..:    |.|.::..:.|
  Fly   589 YGSNNFQLSQKLYTRYSAVAVQIGCPFLGSLNNVLMQLFESGILDKMTAAEYAKQYQEVEATRIY 653

  Fly   777 ---CTRKNTSKQSKANS--------LGLESIGGVFVVLIAGIIVAAVVAFFE 817
               ...||:...|:..|        |.|..:.|.|:.|..|.:.|.|:...|
  Fly   654 KGSVQAKNSEAYSRTESYDSTVISPLNLRMLQGAFIALGVGSLAAGVILLLE 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	33/174 (19%)
		ANF_receptor	39..371	CDD:279440	31/155 (20%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	87/444 (20%)
		Lig_chan	533..807	CDD:278489	62/338 (18%)
Ir40a	NP_610140.4	PBP2_LTTR_substrate	216..338	CDD:330233	26/125 (21%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:328725	23/98 (23%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:328725	30/146 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45463015
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840