DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ekar and gria4b

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_997917.2	Gene:	gria4b / 336069	ZFINID:	ZDB-GENE-030131-8013	Length:	904	Species:	Danio rerio

Alignment Length:	871	Identity:	314/871 - (36%)
Similarity:	478/871 - (54%)	Gaps:	76/871 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLIASGFLLFQF-----LSYGLGVPPLVRIGAIF-SNQPGMYNSELAFRYAI--HRLNMDKSLLP 57
            |.|:...||..|     |:.| ..|..|:||.:| .|....|.   |||.||  |..:.:.|..|
Zfish     1 MRISCNQLLLLFSCVWGLTMG-AFPSSVQIGGLFIRNTDQEYT---AFRLAIFLHNTSPNASEAP 61

  Fly    58 ETTVDYYVEYVNRFDSFETVQKVCKLIRVGVQAVFSPTDSVLATHINSICDALDI-------PNI 115
            ...|. :|:.:...:||......|.....||.|:|...|......:.|.|.||.|       |..
Zfish    62 FNLVP-HVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCGALHISLITPSFPTE 125

  Fly   116 GRSAHDFSINVYPSKQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQLSRSFHGE-------V 173
            |.|  .|.:.:.||   :..|...::.:.:|.||..|::.:.|...|..:... .|:       :
Zfish   126 GES--QFVLQLRPS---IRGALLSLLDHYDWNRFVFLYDTDRGYSILQAIMEK-AGQNGWQVSAI 184

  Fly   174 HMRQVSRDSYVSALNEFKGKEIHNIIIDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETYDL 238
            .:...:..||...|.:...::....:||..:..::.:|:.|:....:...|||:..:...:..:|
Zfish   185 CVENFNDASYRQLLEDLDRRQEKTFVIDLEAERLNNMLEQIVSVGKHVKGYHYIMANLGFKDINL 249

  Fly   239 EDFKYNFVNITSFRLVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESEP----ALMF 299
            |.|.:...|:|.|:|||.::..|.:::            :.:..|..::....::.|    ||.:
Zfish   250 ERFMHGGANVTGFQLVDFSNPMVIKLM------------QRWNKLDQREYPGSDAPPKYTSALTY 302

  Fly   300 DSVYVFAIGLQTL-EQSHSLTLLNIS----CEEENSWDGGLSLINYLNAVEWKGLTGPIQFKD-G 358
            |.|.|.|...:.| .|...::...|:    ......|:.|:.:...|..|..:||||.:||.. |
Zfish   303 DGVMVMAEAFRNLRRQKVDISRRGIAGDCLANPAAPWNQGIDMERTLKQVHLQGLTGNVQFDHYG 367

  Fly   359 QRVQFKLDLIKLKQHSIVKVGEWTPHGHLNITEPSMFF---DAGSMNVTLVVITILETPYVMMHY 420
            :||.:.:|:.:||.:...::|.|.....|.:|:.....   .:|..|.|::|.||:|.||||:.
Zfish   368 RRVNYTMDVFELKSNGPRRIGYWNDADKLVLTQDHALLPNETSGMENRTVIVTTIMEGPYVMLK- 431

  Fly   421 GKN---FTGNERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKAD 482
             ||   :.|||::.|:|||:...|::.:||.|.:.:|||.||||:||||..|||||.:|:..||:
Zfish   432 -KNWEMYEGNEQYEGYCVDLASEIAKHIGFKYKISIVPDGKYGARDPETKIWNGMVGELVYGKAE 495

  Fly   483 LAVGSMTITYARESVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSL 547
            :||..:|||..||.||||:||||:|||||:.|.|......:|||::|||.|||:.::.||..||:
Zfish   496 IAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSV 560

  Fly   548 CIYIVGKLSPIEWKCINACDLENISIG-------NQFSLTDSFWFTIGTFMQQSPDIYPRAMSTR 605
            .:::|.:.||.||   :..:.|..:.|       |:|.:.:|.||::|.||||..||.||::|.|
Zfish   561 VLFLVSRFSPYEW---HTEEPEEGTDGLPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGR 622

  Fly   606 IISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRDSVI 670
            |:...|.||:|||::|||||||||||.|||::|||:|||||.||:|:|||||||||..|||.|.|
Zfish   623 IVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTDIAYGTLDSGSTKEFFRRSKI 687

  Fly   671 ETYKKIWRSMDNKKPSAFTTTYEDGIKRV--NQGNYAFLMESTMLDYIVQR-DCNLTQIGGLLDT 732
            ..|:|:|..|.:.:|:.||.|..:|:.||  ::|.||||:||||.:|..|| .|:..::||.||:
Zfish   688 AVYEKMWSYMKSAEPTVFTKTTAEGVARVRKSKGKYAFLLESTMNEYTEQRKPCDTMKVGGNLDS 752

  Fly   733 KGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIG 797
            ||||:||||||..|..::||:|:|.|:|.:..|.:|||.:..|..:.....|...:.:|.|.::.
Zfish   753 KGYGVATPKGSQLRSAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGGEKDKSSQALSLSNVA 817

  Fly   798 GVFVVLIAGIIVAAVVAFFEFWYNFR 823
            |||.:|:.|:.:|.:||..||.|..|
Zfish   818 GVFYILVGGLGLAMLVALIEFCYKSR 843

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	91/390 (23%)
		ANF_receptor	39..371	CDD:279440	82/357 (23%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	194/381 (51%)
		Lig_chan	533..807	CDD:278489	133/283 (47%)
gria4b	NP_997917.2	Periplasmic_Binding_Protein_Type_1	28..398	CDD:324556	92/391 (24%)
		PBP2_iGluR_AMPA_GluR4	414..793	CDD:270445	195/383 (51%)
		Lig_chan	546..827	CDD:306551	133/283 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591794
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.640