DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ekar and Ir21a

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster

Alignment Length:	759	Identity:	159/759 - (20%)
Similarity:	296/759 - (38%)	Gaps:	162/759 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 SKQLVNYAFNDVIQYLNWTRFGI---LHEKENGIINLHQLSRSFHGEVHMRQVSRDSYVSALNEF 190
            |::|:|:      ..||...||:   ....||......::..:|.|....|           .|.
  Fly    32 SRRLINH------YQLNKEIFGVGMCDGNNENEFRQKRRIVPTFQGNPRPR-----------GEL 79

  Fly   191 KGKEIH-NIIIDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETYD---LEDFKYNFVNITSF 251
            ...:.| |......:|.:..|:..|.|:.:|:......:.|| :|..|   ||:. :..:.||.:
  Fly    80 LASKFHVNSYNFEQTNSLVGLVNKIAQEYLNKCPPVIYYDSF-VEKSDGLILENL-FKTIPITFY 142

  Fly   252 RLVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGLQT----- 311
            .....||...|.     ..::.||      :.:.|...:..|:| ||...:    :|.||
  Fly   143 HGEINADYEAKN-----KRFTSHI------DCNCKSYILFLSDP-LMTRKI----LGPQTESRVV 191

  Fly   312 -LEQSHSLTLLNISCEEENSWDGGLSLINYLNAVEWKGLTGPIQFKDGQRVQFKLDLIKLKQHSI 375
             :.:|....|.:....|.:|     :::|.| .:....:..|::.:.......||....|..::.
  Fly   192 LVSRSTQWRLRDFLSSELSS-----NIVNLL-VIGESLMADPMRERPYVLYTHKLYADGLGSNTP 250

  Fly   376 VKVGEW----TPHGHLNITEPSMF--------FDAGSMNVTLVVITILETPYV--MMHYGKNFTG 426
            |.:..|    ....|:|:. ||.|        |...:.|         :.|::  :.....:..|
  Fly   251 VVLTSWIKGALSRPHINLF-PSKFQFGFAGHRFQISAAN---------QPPFIFRIRTLDSSGMG 305

  Fly   427 NERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMV----AQLMKYKADLAVGS 487
            ..|:.|....:|..||:.:.|.  :|:       .:.|......|:|    .|:::...|:.:..
  Fly   306 QLRWDGVEFRLLTMISKRLNFS--IDI-------TETPTRSNTRGVVDTIQEQIIERTVDIGMSG 361

  Fly   488 MTITYARESVIDFTKPFMNLGIS----ILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLC 548
            :.||  :|.::|..   |::|.|    ....:.:....:..:.|.|....:|:.:        :|
  Fly   362 IYIT--QERLMDSA---MSVGHSPDCAAFITLASKALPKYRAIMGPFQWPVWVAL--------IC 413

  Fly   549 IYIVGKLSPIEWKCINACDLENIS--IGNQFSLTDSFWFTIGTFMQ--QSPDIY----PRAMSTR 605
            :|: |.:.||.:     .|...:|  :||...:.:.||:..|.|..  .....|    .|..|||
  Fly   414 VYL-GGIFPIVF-----TDRLTLSHLMGNWGEVENMFWYVFGMFTNAFSFTGKYSWSNTRKNSTR 472

  Fly   606 IISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRDSVI 670
            ::...:..|::||.:.||.::.||:|.....:.:::..||.. .....|||::|...|:|::|..
  Fly   473 LLIGAYWLFTIIITSCYTGSIIAFVTLPAFPDTVDSVLDLLG-LFFRVGTLNNGGWETWFQNSTH 536

  Fly   671 ETYKKIWRSMDNKKPSAFTTTYEDGIKRVNQG---NYAFLMESTMLDYIVQ---RDCNLTQIGGL 729
            ....::::.|:      |..:.::||..|.|.   |||||.....|:|:||   .|.|:::...|
  Fly   537 IPTSRLYKKME------FVGSVDEGIGNVTQSFFWNYAFLGSKAQLEYLVQSNFSDENISRRSAL 595

  Fly   730 -LDTKGY-----GIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTS----- 783
             |..:.:     |...|:.|.::.||...||..|:.|.|..:      |.:.:...:.:|
  Fly   596 HLSEECFALFQIGFLFPRESVYKIKIDSMILLAQQSGLIAKI------NNEVSWVMQRSSSGRLL 654

  Fly   784 KQSKANS----------LGLESIGGVFVVLIAGIIVAAVVAFFE 817
            :.|.:||          |......|:|:::..|..:.|.....|
  Fly   655 QASSSNSLREIIQEERQLTTADTEGMFLLMALGYFLGATALVSE 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	54/275 (20%)
		ANF_receptor	39..371	CDD:279440	50/254 (20%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	89/398 (22%)
		Lig_chan	533..807	CDD:278489	73/308 (24%)
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	74/328 (23%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	69/281 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910