DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ekar and Grik3

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_001106187.1	Gene:	Grik3 / 298521	RGDID:	71027	Length:	919	Species:	Rattus norvegicus

Alignment Length:	915	Identity:	353/915 - (38%)
Similarity:	550/915 - (60%)	Gaps:	78/915 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SGFLLFQF-LSYGLGVPPLVRIGAIFSNQPG-----MYNSELAFRYAIHRLNMDKSLLPETTVDY 63
            :|||:..| :....|:|.::|||.||....|     |...|.|||::.:.:|.:::|||.||:.|
  Rat    17 AGFLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRNRTLLPNTTLTY 81

  Fly    64 YVEYVNRFDSFETVQKVCKLIRVGVQAVFSPTDSVLATHINSICDALDIPNIG-RSAH------- 120
            .::.::..||||..:|.|..:.:||.|:|.|:.......:.|||:||::|:|. |..|
  Rat    82 DIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHPLDNKD 146

  Fly   121 DFSINVYPSKQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQL----SRSFHGEVHMRQVSRD 181
            .|.:|:||....:::|..|::|.|.|....::::...|:|.|.:|    || ::..:.:||:..|
  Rat   147 TFYVNLYPDYASLSHAILDLVQSLKWRSATVVYDDSTGLIRLQELIMAPSR-YNIRLKIRQLPID 210

  Fly   182 SYVS--ALNEFK-GKEIHNIIIDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETYDLEDFKY 243
            |..|  .|.|.| |:|...|...:::....||.:.:....|.|| ||::||:.||...|||.::|
  Rat   211 SDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEY-YHFIFTTLDLYALDLEPYRY 274

  Fly   244 NFVNITSFRLVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIG 308
            :.||:|.||:::..:..|..|::...:.......:....|   ...::.::.||::|:|::.::.
  Rat   275 SGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRAESGL---LDGVMMTDAALLYDAVHIVSVC 336

  Fly   309 LQTLEQSHSLTLLNISCEEENSWDGGLSLINYLNAVEWKGLTGPIQFK--DGQRVQFKLDLIKLK 371
            .|...|   :|:.::.|....:|..|...:|::...:|:||||.|.|.  .|.|..|.||:|.||
  Rat   337 YQRAPQ---MTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLK 398

  Fly   372 QHSIVKVGEWTPHGHLNITEPSMFFDAGSMNVT-------LVVITILETPYVMMHYG-KNFTGNE 428
            :..:.|||.|:|...|||||.:   .....|||       |:|.|:||.|:||.... :...||:
  Rat   399 EDGLEKVGVWSPADGLNITEVA---KGRGPNVTDSLTNRSLIVTTLLEEPFVMFRKSDRTLYGND 460

  Fly   429 RFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTITYA 493
            ||.|:|:|:|:.::..:||.|.:.||.|.||||:| :.|:|||||.:|:.:||||||..:|||:.
  Rat   461 RFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQD-DKGQWNGMVKELIDHKADLAVAPLTITHV 524

  Fly   494 RESVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPI 558
            ||..|||:||||.||:|||::.|......:|||:|||:.:||:|||:||..||..::::.:.||.
  Rat   525 REKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPY 589

  Fly   559 EWKCINACDLENISIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYT 623
            ||...:.|:..:..:.|.|:|.:||||.:|:.|||..::.|:|:|||||...|.||:|||::|||
  Rat   590 EWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYT 654

  Fly   624 ANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSAF 688
            ||||||||.|||.:||::|:|||.||:|.||.:..|:|||||:.|.|.|::|:|..| :.||||.
  Rat   655 ANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFM-SSKPSAL 718

  Fly   689 TTTYEDGIKRVNQGNYAFLMESTMLDYIVQRDCNLTQIGGLLDTKGYGIATPKGSPWRDKISLAI 753
            ....|:||:|....:||.|||||.::||.||:|||||||||:|:|||||.||.|||:||||::||
  Rat   719 VKNNEEGIQRTLTADYALLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAI 783

  Fly   754 LELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFEF 818
            |:|||...:.::.:|||:.:.  |..:   :..:|::||::.|||:|:||.||::::.:||..||
  Rat   784 LQLQEEDKLHIMKEKWWRGSG--CPEE---ENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEF 843

  Fly   819 WYNFRYNYEATPSQSVVNNKYNQDGILESERNYTPPDRSFWIEIAEELRYASWCMNKQKR----P 879
            .|..|..                     :||.    .|||...:|:|:|::..|..:.|.    |
  Rat   844 IYKLRKT---------------------AERE----QRSFCSTVADEIRFSLTCQRRLKHKPQPP 883

  Fly   880 ALTRT 884
            .:.:|
  Rat   884 MMVKT 888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	118/385 (31%)
		ANF_receptor	39..371	CDD:279440	104/348 (30%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	193/376 (51%)
		Lig_chan	533..807	CDD:278489	138/273 (51%)
Grik3	NP_001106187.1	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388	120/390 (31%)
		ANF_receptor	55..398	CDD:279440	104/350 (30%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	190/369 (51%)
		Lig_chan	564..832	CDD:278489	138/273 (51%)
		Glutamate binding	690..692		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350188
Domainoid	1	1.000	362	1.000	Domainoid score	I917
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.710