Protein Alignment Ekar and Gria3

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_116785.2
• Gene: Gria3 / 29628
• RGDID: 70958
• Length: 888
• Species: Rattus norvegicus
• Alignment Length: 909
• Identity: 320/909 - (35%)
• Similarity: 483/909 - (53%)
• Gaps: 102/909 - (11%)

  Fly     1 MLIASGFLLFQFL--SYGLGVPPLVRIGAIFSNQPGMYNSELAFRYAIHRLNMDKSLLPETT--- 60
            :|.|..||:...|  |:| |.|..:.||.:|.......:|  |||:|:...|.:::    ||
  Rat     5 VLRAVFFLVLGLLGHSHG-GFPNTISIGGLFMRNTVQEHS--AFRFAVQLYNTNQN----TTEKP 62

  Fly    61 --VDYYVEYVNRFDSFETVQKVCKLIRVGVQAVFSPTDSVLATHINSICDALD----IPNIGRSA 119
              ::|:|::::..:||......|.....||.|:|...|.:....:.|.|.||.    .|:....|
  Rat    63 FHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFPTDA 127

  Fly   120 H-DFSINVYPSKQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQLSRSF---HGEVHMRQVSR 180
            . .|.|.:.|:   :..|...::.|..|.:|..|::.|.|...|..:..:.   :.:|..|.|..
  Rat   128 DVQFVIQMRPA---LKGAILSLLGYYKWEKFVYLYDTERGFSVLQAIMEAAVQNNWQVTARSVGN 189

  Fly   181 ----DSYVSALNEFKGKEIHNIIIDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETYDLEDF 241
                ..:...:.|...::....:||.....|:.:|:.::....:...|||:..:.......||..
  Rat   190 IKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTDILLERV 254

  Fly   242 KYNFVNITSFRLVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFA 306
            .:...|||.|::|:..:..|:|.::.........|.:       .|:..|:...||..|::.|.|
  Rat   255 MHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPE-------AKNAPLKYTSALTHDAILVIA 312

  Fly   307 IGLQTLEQSHSLTLLNISCEEENS-----------WDGGLSLINYLNAVEWKGLTGPIQFKD-GQ 359
            ...:.|.:.      .:......|           |..|:.:...|..|:.:|:||.|||.. |:
  Rat   313 EAFRYLRRQ------RVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDTYGR 371

  Fly   360 RVQFKLDLIKLKQHSIVKVGEW------TPHGHLNITEPSMFFDAGSMNVTLVVITILETPYVMM 418
            |..:.:|:.::|.....|.|.|      .|.....|:..|    :.|.|.|:||.||||:||||
  Rat   372 RTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDS----SSSENRTIVVTTILESPYVM- 431

  Fly   419 HYGKN---FTGNERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYK 480
             |.||   ..||||:.|:|||:...|::.|...|.|.:|.|.||||:||||..|||||.:|:..:
  Rat   432 -YKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGR 495

  Fly   481 ADLAVGSMTITYARESVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLV 545
            ||:||..:|||..||.||||:||||:|||||:.|.|......:|||::|||.|||:.::.||..|
  Rat   496 ADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGV 560

  Fly   546 SLCIYIVGKLSPIEWKCINACDLENIS-----------IGNQFSLTDSFWFTIGTFMQQSPDIYP 599
            |:.:::|.:.||.||      .||:.:           ..|:|.:.:|.||::|.||||..||.|
  Rat   561 SVVLFLVSRFSPYEW------HLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISP 619

  Fly   600 RAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTF 664
            |::|.||:...|.||:|||::|||||||||||.|||::|||:|||||.||||:|||||||||..|
  Rat   620 RSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEF 684

  Fly   665 FRDSVIETYKKIWRSMDNKKPSAFTTTYEDGIKRV--NQGNYAFLMESTMLDYIVQR-DCNLTQI 726
            ||.|.|..|:|:|..|.:.:||.||.|..||:.||  ::|.:|||:||||.:||.|| .|:..::
  Rat   685 FRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKV 749

  Fly   727 GGLLDTKGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSL 791
            ||.||:||||:||||||.....::||:|:|.|:|.:..|.:|||.:..| |..|::..:.|.::|
  Rat   750 GGNLDSKGYGVATPKGSALGTPVNLAVLKLSEQGILDKLKNKWWYDKGE-CGAKDSGSKDKTSAL 813

  Fly   792 GLESIGGVFVVLIAGIIVAAVVAFFEFWYNFR------------YNYEATPSQSVVNNKYNQDG 843
            .|.::.|||.:|:.|:.:|.:||..||.|..|            .|::..|:.:..|....::|
  Rat   814 SLSNVAGVFYILVGGLGLAMMVALIEFCYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREG 877

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	86/400 (22%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	199/385 (52%)
		Lig_chan	532..806	CDD:459656	137/287 (48%)
Gria3	NP_116785.2	PBP1_iGluR_AMPA_GluR3	29..403	CDD:380610	86/395 (22%)
		PBP2_iGluR_AMPA	416..799	CDD:270433	201/391 (51%)