back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ekar and Grik1

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_001104587.1	Gene:	Grik1 / 29559	RGDID:	2732	Length:	949	Species:	Rattus norvegicus

Alignment Length:	944	Identity:	368/944 - (38%)
Similarity:	554/944 - (58%)	Gaps:	87/944 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SGFLLFQFLSYGL--GVPPLVRIGAIF---SNQPGMYNSELAFRYAIHRLNMDKSLLPETTVDYY 64
            :.:.|..||.|.|  ..|.::|||.||   .|:| :...||||::|:..:|.:::|:|.||:.|.
  Rat    17 TSWTLLYFLCYILPQTSPQVLRIGGIFETVENEP-VNVEELAFKFAVTSINRNRTLMPNTTLTYD 80

  Fly    65 VEYVNRFDSFETVQKVCKLIRVGVQAVFSPTDSVLATHINSICDALDIPNI-GRSAHD------- 121
            ::.:|.|||||..::.|..:.:||.|:|.|:.|...:.:.|||:||::|:| .|..|.
  Rat    81 IQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDSRDL 145

  Fly   122 FSINVYPSKQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQLSRS---FHGEVHMRQV---SR 180
            |.||:||....::.|..|::.|.||....:::|...|:|.|.:|.::   ::.::.:||:   ::
  Rat   146 FYINLYPDYAAISRAVLDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLPPANK 210

  Fly   181 DSYVSALNEFKGKEIHNIIIDTNSNGISILLKNIL-QQQMNEYKYHYLFTSFDLETYDLEDFKYN 244
            |: ...|.|.|..:...:|.|.:....:.:||.|| ...|.|| |||.||:.||...|||.::|:
  Rat   211 DA-KPLLKEMKKSKEFYVIFDCSHETAAEILKQILFMGMMTEY-YHYFFTTLDLFALDLELYRYS 273

  Fly   245 FVNITSFRLVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGL 309
            .||:|.|||::..:..|..|::...:.......:|...|   ...::.:|.|||:|:||:.||..
  Rat   274 GVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGL---LDGMMTTEAALMYDAVYMVAIAS 335

  Fly   310 QTLEQSHSLTLLNISCEEENSWDGGLSLINYLNAVEWKGLTGPIQFK--DGQRVQFKLDLIKLKQ 372
            ....|   ||:.::.|.....|..|...:|.:....|.||||.|.|.  ||.|..|.||:|.||:
  Rat   336 HRASQ---LTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTGRITFNKTDGLRKDFDLDIISLKE 397

  Fly   373 HSI---------------VKVGEWTPHGHLNITEPSMFFDAGS------MNVTLVVITILETPYV 416
            ...               .|:|.|..:..||:|:.:.  |..:      .|.||:|.||||.|||
  Rat   398 EGTEKASGEVSKHLYKVWKKIGIWNSNSGLNMTDGNR--DRSNNITDSLANRTLIVTTILEEPYV 460

  Fly   417 MMHYG-KNFTGNERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYK 480
            |.... |...||:||.|:|:|:|:.:|..:||.|.:.||||.||||:: :.|||||||.:|:.::
  Rat   461 MYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQN-DKGEWNGMVKELIDHR 524

  Fly   481 ADLAVGSMTITYARESVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLV 545
            |||||..:||||.||.||||:||||.||||||::.|......:|||:|||:.:||:|||:|...|
  Rat   525 ADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGV 589

  Fly   546 SLCIYIVGKLSPIEWKCINACDLENISIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISST 610
            |..::::.:.:|.||...:.|:.::..:.|.|:|.:||||.:|..|||..::.|:|:||||:...
  Rat   590 SCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGI 654

  Fly   611 WGFFSLIIVASYTANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRDSVIETYKK 675
            |.||:|||::|||||||||||.|||.:||::|:|||.||:|.||.:..|||||||:.|.|.||:|
  Rat   655 WWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEK 719

  Fly   676 IWRSMDNKKPSAFTTTYEDGIKRVNQGNYAFLMESTMLDYIVQRDCNLTQIGGLLDTKGYGIATP 740
            :|..|.:::.||.....::||:||...:||.|||||.::|:.||:|||||||||:|:||||:.||
  Rat   720 MWAFMSSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTP 784

  Fly   741 KGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIA 805
            .|||:||||::|||:|||.|.:.|:.:|||:...  |..:::   .:|::||:|:|||:|:||.|
  Rat   785 IGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNG--CPEEDS---KEASALGVENIGGIFIVLAA 844

  Fly   806 GIIVAAVVAFFEFWYNFRYNYEATPSQSVVNNKYNQDG--------ILESERNYTPPDRSFWIE- 861
            |::::..||..||.|..|           .||...|.|        .....|.:.....|..:|
  Rat   845 GLVLSVFVAIGEFLYKSR-----------KNNDVEQKGKSSRLRFYFRNKVRFHGSKKESLGVEK 898

  Fly   862 ------IAEELRYASWCMNKQKRPALTRTCSKCT 889
                  |.|||..:.....|.|:.:.|:..|..|
  Rat   899 CLSFNAIMEELGISLKNQKKLKKKSRTKGKSSFT 932

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.