Protein Alignment Ekar and GRIN2C

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: XP_054171851.1
• Gene: GRIN2C / 2905
• HGNCID: 4587
• Length: 1265
• Species: Homo sapiens
• Alignment Length: 912
• Identity: 210/912 - (23%)
• Similarity: 359/912 - (39%)
• Gaps: 267/912 - (29%)

  Fly   170 HGEVHMRQVSRDSYVSALNEFKGKEIHNIIIDTNSNGISILL------KNILQQQMN-EYKYHYL 227
            ||.|....|..:: |:.:.:|...:.|..|:.. |.|.:::|      ...||..:: |.:...|
Human    91 HGIVFEDNVDTEA-VAQILDFISSQTHVPILSI-SGGSAVVLTPKEPGSAFLQLGVSLEQQLQVL 153

  Fly   228 FTSFDLETYDLEDFKYNFVNIT----------------------SFRLVD--TADVG-------V 261
            |..  ||.||...|..    ||                      |:||:|  |.::|       .
Human   154 FKV--LEEYDWSAFAV----ITSLHPGHALFLEGVRAVADASHVSWRLLDVVTLELGPGGPRART 212

  Fly   262 KQILKDI------------------------GLYS-HHIFKKPYLNLHIKKSTILESEPAL---- 297
            :::|:.:                        ||.. .|::..|.|.|   .||  ::.||.
Human   213 QRLLRQLDAPVFVAYCSREEAEVLFAEAAQAGLVGPGHVWLVPNLAL---GST--DAPPATFPVG 272

  Fly   298 ----------------MFDSVYVFAIGLQTLEQSHSLTLLNISCEEENSWDGGLS-----LINYL 341
                            :.|.|.:.|:|..:..:.|.  .|.....:.....|.:|     ...:|
Human   273 LISVVTESWRLSLRQKVRDGVAILALGAHSYWRQHG--TLPAPAGDCRVHPGPVSPAREAFYRHL 335

  Fly   342 NAVEWKGLTGPIQFKD------GQRVQFKLDLIKLKQHSIVK-VGEWTPHGHLNITEPSMFFDAG 399
            ..|.|:|       :|      |..||..:.:|.|.:|.:.: ||.| .||.|.:..|.....:.
Human   336 LNVTWEG-------RDFSFSPGGYLVQPTMVVIALNRHRLWEMVGRW-EHGVLYMKYPVWPRYSA 392

  Fly   400 SMNVT-----LVVITILETPYVMMHYGKNFTG-------------NERF-------------YGF 433
            |:...     |.|.|:.|.|:|::......||             |..|             .||
Human   393 SLQPVVDSRHLTVATLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHTFSSGDVAPYTKLCCKGF 457

  Fly   434 CVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTITYARESVI 498
            |:|||:.::|.|.|.|.|.||.:.|:|.:  ..|.||||:.::...:||:|:||:||...|..::
Human   458 CIDILKKLARVVKFSYDLYLVTNGKHGKR--VRGVWNGMIGEVYYKRADMAIGSLTINEERSEIV 520

  Fly   499 DFTKPFMNLGISILF--KVPTSEPTRLFSFMNPLAIEIWIYVLI-AYFLVSLCIYIVGKLSPIEW 560
            ||:.||:..|||::.  ...|..|:   :|:.|.:..:|:.:.: ...:|::.:::....||:.:
Human   521 DFSVPFVETGISVMVARSNGTVSPS---AFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSY 582

  Fly   561 KCINACDLENISIGNQ-----FSLTDSFWFTIG-TFMQQSPDIYPRAMSTRIISSTWGFFSLIIV 619
            .       :|::.|.:     |::..|.|.... .|....|...||..:::|:...|.||::|.:
Human   583 N-------QNLTRGKKSGGPAFTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFL 640

  Fly   620 ASYTANLAAFLTTERMINPIENAEDLAS----QTEIS-----------------------YGTLD 657
            ||||||||||:..|:.|:.:....|..|    .|.::                       :||:.
Human   641 ASYTANLAAFMIQEQYIDTVSGLSDKKSLHLENTGVAWTAFKTFCSDYFQRPQDQYPPFRFGTVP 705

  Fly   658 SGSTMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYEDGIKRVNQGNY---------AFLMESTML 713
            :|||....|.:        :|.|..........:.||.:..:..|:.         ||:.::.:|
Human   706 NGSTERNIRSN--------YRDMHTHMVKFNQRSVEDALTSLKMGSEAQPVPRKLDAFIYDAAVL 762

  Fly   714 DYIVQRD--CNLTQIGG--LLDTKGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTD 774
            :|:..:|  |.|..||.  :..|.|||||..|.|.|:..|.||:|:....|:.|.|...|...
Human   763 NYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWLSG-- 825

  Fly   775 ETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFE---FWYNFRYNYEATPSQSVVN 836
             .|  :|...:..::.|.::::.|||.:|:..:.:|.:|..:|   :| ..|::         |.
Human   826 -IC--QNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVYW-KLRHS---------VP 877

  Fly   837 NKYNQDGILESERNY-----------TPPDRSFWIEIAEELRYASWCMNKQKRPALTRTCSKCTI 890
            |....|.:|...|..           :||                    :|..|.||.:.::.::
Human   878 NSSQLDFLLAFSRGIYSCFSGVQSLASPP--------------------RQASPDLTASSAQASV 922

  Fly   891 PK 892
            .|
Human   923 LK 924

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	65/314 (21%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	119/448 (27%)
		Lig_chan	532..806	CDD:459656	77/320 (24%)
GRIN2C	XP_054171851.1	PBP1_iGluR_NMDA_NR2	28..384	CDD:380601	65/315 (21%)
		PBP2_iGluR_NMDA_Nr2	400..829	CDD:270436	120/453 (26%)
		NMDAR2_C	866..>941	CDD:463148	14/89 (16%)