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Protein Alignment Ekar and GRIN2B

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_000825.2	Gene:	GRIN2B / 2904	HGNCID:	4586	Length:	1484	Species:	Homo sapiens

Alignment Length:	932	Identity:	220/932 - (23%)
Similarity:	374/932 - (40%)	Gaps:	242/932 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 PPLVRIGAIFSNQPGMYNSELAFRYA-----IHRLNMDKSLLPETTVDYYVEYV--NRFDSFETV 77
            ||.:.|..|....    :.|:|.:.|     .|.|    |::|.      ||.|  |..|....:
Human    32 PPSIGIAVILVGT----SDEVAIKDAHEKDDFHHL----SVVPR------VELVAMNETDPKSII 82

  Fly    78 QKVCKLIR-VGVQAVFSPTDSVLATHINSICDALDI-------PNIGRSAHDFSINVYPSKQLVN 134
            .::|.|:. ..:|.|....|    |...:|...||.       |.:|  .|..|..:...|...:
Human    83 TRICDLMSDRKIQGVVFADD----TDQEAIAQILDFISAQTLTPILG--IHGGSSMIMADKDESS 141

  Fly   135 YAFN-------------DVIQYLNWTRFGILHEKENG---IIN--LHQLSRSFHG----EVHMRQ 177
            ..|.             ::::..:|..|.|:.....|   .:|  ...:..||.|    ||.:..
Human   142 MFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIENSFVGWELEEVLLLD 206

  Fly   178 VSRDSYVSAL-NEFKGKEIHNIIIDTNSNGISILLKNILQQQMNEYKYHYLFTSF---DLETYDL 238
            :|.|...|.: |:.|..:...|::.......:.:.:......:..|.|.::..|.   |.:|...
Human   207 MSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPA 271

  Fly   239 EDFKYNFVNITSFRLVDTADVGVKQILKD---------IGLYSHHIF----KKPYLNLHIKKSTI 290
            | |....::::    .|..|.|:...::|         ..:.|.|.|    |....|.|.|:
Human   272 E-FPTGLISVS----YDEWDYGLPARVRDGIAIITTAASDMLSEHSFIPEPKSSCYNTHEKR--- 328

  Fly   291 LESEPALMFDSVYVFAIGLQTLEQSHSLT--LLNISCEEENSWDGGLSLINYLNAVEWKGLTGPI 353
                       :|          ||:.|.  |:|::.|..|                       :
Human   329 -----------IY----------QSNMLNRYLINVTFEGRN-----------------------L 349

  Fly   354 QF-KDGQRVQFKLDLIKL-KQHSIVKVGEWTPHG---------------------HLNITEPSMF 395
            .| :||.::..||.:|.| |:....:||:|....                     ||:|
Human   350 SFSEDGYQMHPKLVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDDHLSI------ 408

  Fly   396 FDAGSMNVTLVVITILETPYVMMH--------------------YGKNFTGNERFY------GFC 434
                        :|:.|.|:|::.                    ..:|.|..|..|      |||
Human   409 ------------VTLEEAPFVIVESVDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFC 461

  Fly   435 VDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTITYARESVID 499
            :|||:.||:.|.|.|.|.||.:.|:|.|  ..|.||||:.:::..:|.:||||:||...|..|:|
Human   462 IDILKKISKSVKFTYDLYLVTNGKHGKK--INGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVD 524

  Fly   500 FTKPFMNLGISILFKVP--TSEPTRLFSFMNPLAIEIWIYVLIAYFLVS-LCIYIVGKLSPIEWK 561
            |:.||:..|||::....  |..|:   :|:.|.:.::|:.:.:...:|| :.:::....||:.:
Human   525 FSVPFIETGISVMVSRSNGTVSPS---AFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGY- 585

  Fly   562 CINACDLENISIGN-QFSLTDSFWFTIG-TFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTA 624
              |.|..:....|. .|::..:.|...| .|....|...|:..:::|:.|.|.||::|.:|||||
Human   586 --NRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTA 648

  Fly   625 NLAAFLTTERMINPIENAEDLASQ------TEISYGTLDSGSTMTFFRDSVIETY----KKIWRS 679
            |||||:..|..::.:....|...|      ....:||:.:|||....|::..|.:    |...|.
Human   649 NLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRG 713

  Fly   680 MDNKKPSAFTTTYEDGIKRVNQGNY-AFLMESTMLDYIVQRD--CNLTQIGG--LLDTKGYGIAT 739
            :|            |.:..:..|.. ||:.::.:|:|:..||  |.|..||.  :..:.|||||.
Human   714 VD------------DALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAI 766

  Fly   740 PKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLI 804
            .|.|.|:.::.||||:|...|:::.|...|.     |....|...:..::.|.::::.|||.:|.
Human   767 QKDSGWKRQVDLAILQLFGDGEMEELEALWL-----TGICHNEKNEVMSSQLDIDNMAGVFYMLG 826

  Fly   805 AGIIVAAVVAFFE--FWYNFRY 824
            |.:.::.:....|  |::.||:
Human   827 AAMALSLITFICEHLFYWQFRH 848

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.