Protein Alignment Ekar and GRIN2A

DIOPT Version :9

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: XP_016878661.1
• Gene: GRIN2A / 2903
• HGNCID: 4585
• Length: 1516
• Species: Homo sapiens
• Alignment Length: 919
• Identity: 214/919 - (23%)
• Similarity: 386/919 - (42%)
• Gaps: 178/919 - (19%)

  Fly    20 PPLVRIGAIFSNQPGMYNSELAFRYAIHRLNMDKSLLPETT------VDYYVEYVNRFDSFETVQ 78
            ||.:.|..:..:...:...||...:.           ||..      |:.....:||.|....:.
Human    83 PPALNIAVMLGHSHDVTERELRTLWG-----------PEQAAGLPLDVNVVALLMNRTDPKSLIT 136

  Fly    79 KVCKLI---RVGVQAVFSPTD-SVLATHINSICDALDIPNIGRSAHDFSINVYPSKQLVNYAFN- 138
            .||.|:   |:........|| ..:|..::.|.....:|.:|  .|..:..:...|...:..|.
Human   137 HVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHTFVPILG--IHGGASMIMADKDPTSTFFQF 199

  Fly   139 ------------DVIQYLNWTRFGILHEKENG---IINLHQ--LSRSFHGEVHMRQVSRD-SYVS 185
                        .::|..:|..|.::.....|   .|:..:  :..||.|......::.| |:..
Human   200 GASIQQQATVMLKIMQDYDWHVFSLVTTIFPGYREFISFVKTTVDNSFVGWDMQNVITLDTSFED 264

  Fly   186 ALNEFKGKEIHN--IIIDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETYDL--EDFKYNFV 246
            |..:.:.|:||:  |::..:.:...::|.......:..|.:.::..|......:|  ::|....:
Human   265 AKTQVQLKKIHSSVILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLI 329

  Fly   247 NITSFRLVDTADVGVKQILKD-IGLY----SHHIFKKPYLNLHIKKSTILESE-PALMFDSVYVF 305
            :::    .|..|..::..::| ||:.    |..:.|..|:. ..|.|...:.| |.:...:::.|
Human   330 SVS----YDDWDYSLEARVRDGIGILTTAASSMLEKFSYIP-EAKASCYGQMERPEVPMHTLHPF 389

  Fly   306 AIGLQTLEQSHSLTLLNISCEEENSWDGGLSLINYLNAVEWKGLTGPIQFKDGQRVQFKLDLIKL 370
            .:.:                    :|||             |.|:..   ::|.:|..:|.:|.|
Human   390 MVNV--------------------TWDG-------------KDLSFT---EEGYQVHPRLVVIVL 418

  Fly   371 -KQHSIVKVGEWTPH----GHLNITEPSMFFDAGSMNVTLVVITILETPYVMMH----------- 419
             |.....|||:|..|    .|........|.|....:..|.::|:.|.|:|::.
Human   419 NKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDPLTETCVR 483

  Fly   420 -------YGK-NFTGNERF------YGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWN 470
                   :.| |.:.||..      .|||:|||:.:||.|.|.|.|.||.:.|:|.|  ....||
Human   484 NTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKK--VNNVWN 546

  Fly   471 GMVAQLMKYKADLAVGSMTITYARESVIDFTKPFMNLGISILFKVP--TSEPTRLFSFMNPLAIE 533
            ||:.:::..:|.:||||:||...|..|:||:.||:..|||::....  |..|:   :|:.|.:..
Human   547 GMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSPS---AFLEPFSAS 608

  Fly   534 IWIYVLIAYFLVS-LCIYIVGKLSPIEWKCINACDLENISIGN-----QFSLTDSFWFTIG-TFM 591
            :|:.:.:...:|| :.:::....||:.:.       .|::.|.     .|::..:.|...| .|.
Human   609 VWVMMFVMLLIVSAIAVFVFEYFSPVGYN-------RNLAKGKAPHGPSFTIGKAIWLLWGLVFN 666

  Fly   592 QQSPDIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLASQTEISY--- 653
            ...|...|:..:::|:.|.|.||::|.:||||||||||:..|..::.:....|...|....|
Human   667 NSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPP 731

  Fly   654 ---GTLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYEDGIKRVNQGNY-AFLMESTMLD 714
               ||:.:|||....|::.  .|...:.:..|:|      ..||.:..:..|.. ||:.::.:|:
Human   732 FRFGTVPNGSTERNIRNNY--PYMHQYMTKFNQK------GVEDALVSLKTGKLDAFIYDAAVLN 788

  Fly   715 YIVQRD--CNLTQIGG--LLDTKGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDE 775
            |...||  |.|..||.  :..|.|||||..|||||:.:|.||:|:....|:::.|...|.
Human   789 YKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWL----- 848

  Fly   776 TCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFE--FWYNFRYNYEATPSQSVVNNK 838
            |....|...:..::.|.::::.|||.:|.|.:.::.:...:|  |::..|:.:....|
Human   849 TGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYWKLRFCFTGVCS------- 906

  Fly   839 YNQDGILES 847
             ::.|:|.|
Human   907 -DRPGLLFS 914

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	72/407 (18%)
		ANF_receptor	39..371	CDD:279440	64/371 (17%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	123/413 (30%)
		Lig_chan	533..807	CDD:278489	81/291 (28%)
GRIN2A	XP_016878661.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810