Protein Alignment Ekar and GRIK5

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: XP_011525167.1
• Gene: GRIK5 / 2901
• HGNCID: 4583
• Length: 982
• Species: Homo sapiens
• Alignment Length: 856
• Identity: 324/856 - (37%)
• Similarity: 488/856 - (57%)
• Gaps: 54/856 - (6%)

  Fly     8 LLFQFLSYGLGVPPLVRIGAIFSNQPGMYNSE-LAFRYAIHRLNMDKSLLPETTVDYYVEYVNRF 71
            |:..|.|....|...:|:.||..:|......| ||...|..::|....:..:..|:..:..:.|.
Human     9 LIVAFASPSCQVLSSLRMAAILDDQTVCGRGERLALALAREQINGIIEVPAKARVEVDIFELQRD 73

  Fly    72 DSFETVQKVCKLIRVGVQAVFSPTDS-VLATHINSICDALDIPNIGRSAHD---------FSINV 126
            ..:||...:|:::..||.:|..|:.| ..|:.::.||...:||:|.....:         .|:::
Human    74 SQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVGPEETPRLQYLRFASVSL 138

  Fly   127 YPSKQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQLSRSF-----HGEVHMRQVSRDSYVSA 186
            |||.:.|:.|.:.:::..|:....::..|...::.|.:|.|.|     ...|.|...|||. ...
Human   139 YPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRGFLISKETLSVRMLDDSRDP-TPL 202

  Fly   187 LNEFKGKEIHNIIIDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETYDLEDFKYNFVNITSF 251
            |.|.:..::..||||.|::...::|:...:..|....|.|:.|:.|.....|:....:..||..|
Human   203 LKEIRDDKVSTIIIDANASISHLILRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGF 267

  Fly   252 RLVDTADVGVKQILKDIGL-YSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGLQTLEQS 315
            .:.:|:.....:.::.:.: :..:.....||...:        ..|||||:|:|....::.|.:|
Human   268 SMFNTSHPFYPEFVRSLNMSWRENCEASTYLGPAL--------SAALMFDAVHVVVSAVRELNRS 324

  Fly   316 HSLTLLNISCEEENSWDGGLSLINYLNAVEWKGLTGPIQFKD-GQRVQFKLDLIKLKQHSIVKVG 379
            ..:.:..::|...|.|..|.||:|||..||:.||||.::|.. |||..:.|.:::..:....::|
Human   325 QEIGVKPLACTSANIWPHGTSLMNYLRMVEYDGLTGRVEFNSKGQRTNYTLRILEKSRQGHREIG 389

  Fly   380 EWTPHGHL--NITEPSMFFDAGSMNVTLVVITILETPYVMMHYGKNF---TGNERFYGFCVDILE 439
            .|..:..|  |.|...:.......|.||||.||||.||||..  .||   :|||||.|||||:|.
Human   390 VWYSNRTLAMNATTLDINLSQTLANKTLVVTTILENPYVMRR--PNFQALSGNERFEGFCVDMLR 452

  Fly   440 TISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLM-KYKADLAVGSMTITYARESVIDFTKP 503
            .::..:.|.|.|.||.|..|||.:| .|.|.|||.:|: :.||||||.:.|||..||.||||:||
Human   453 ELAELLRFRYRLRLVEDGLYGAPEP-NGSWTGMVGELINRQKADLAVAAFTITAEREKVIDFSKP 516

  Fly   504 FMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEW----KCIN 564
            ||.||||||::|........|||::|.:..:|:::|:||..||..:::..:|||.||    .|:.
Human   517 FMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLR 581

  Fly   565 ACD--LENISIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTANLA 627
            |..  ||     ||::|.:|.||.:|.||||..:|.|||:|||.:|..|..|:|||::|||||||
Human   582 ARPHILE-----NQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLA 641

  Fly   628 AFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFTTTY 692
            ||||.:||..|:|:|:|||.||.|.|||:.:|||||||::|..:||:::|..|.:|:||.|..:.
Human   642 AFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKST 706

  Fly   693 EDGIKRVNQGNYAFLMESTMLDYIVQRDCNLTQIGGLLDTKGYGIATPKGSPWRDKISLAILELQ 757
            |:||.||....||||:||||.:|..:.:|||||||||||||||||..|.|||:||:|:||||:||
Human   707 EEGIARVLNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQ 771

  Fly   758 ERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFEFWYNF 822
            |...:::|..|||:.  ..|.::   :..:|..||:|:|||:|:|||.|:|:|..||..||.::.
Human   772 ENNRLEILKRKWWEG--GRCPKE---EDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWST 831

  Fly   823 RYNYEA--TPS 831
            |.:.|:  ||:
Human   832 RRSAESEETPA 842

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	95/385 (25%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	200/378 (53%)
		Lig_chan	532..806	CDD:459656	141/279 (51%)
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	23..401	CDD:380616	94/386 (24%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:473866	200/378 (53%)