DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ekar and GRIK5

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	XP_011525167.1	Gene:	GRIK5 / 2901	HGNCID:	4583	Length:	982	Species:	Homo sapiens

Alignment Length:	856	Identity:	324/856 - (37%)
Similarity:	488/856 - (57%)	Gaps:	54/856 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLFQFLSYGLGVPPLVRIGAIFSNQPGMYNSE-LAFRYAIHRLNMDKSLLPETTVDYYVEYVNRF 71
            |:..|.|....|...:|:.||..:|......| ||...|..::|....:..:..|:..:..:.|.
Human     9 LIVAFASPSCQVLSSLRMAAILDDQTVCGRGERLALALAREQINGIIEVPAKARVEVDIFELQRD 73

  Fly    72 DSFETVQKVCKLIRVGVQAVFSPTDS-VLATHINSICDALDIPNIGRSAHD---------FSINV 126
            ..:||...:|:::..||.:|..|:.| ..|:.::.||...:||:|.....:         .|:::
Human    74 SQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVGPEETPRLQYLRFASVSL 138

  Fly   127 YPSKQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQLSRSF-----HGEVHMRQVSRDSYVSA 186
            |||.:.|:.|.:.:::..|:....::..|...::.|.:|.|.|     ...|.|...|||. ...
Human   139 YPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRGFLISKETLSVRMLDDSRDP-TPL 202

  Fly   187 LNEFKGKEIHNIIIDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETYDLEDFKYNFVNITSF 251
            |.|.:..::..||||.|::...::|:...:..|....|.|:.|:.|.....|:....:..||..|
Human   203 LKEIRDDKVSTIIIDANASISHLILRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGF 267

  Fly   252 RLVDTADVGVKQILKDIGL-YSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGLQTLEQS 315
            .:.:|:.....:.::.:.: :..:.....||...:        ..|||||:|:|....::.|.:|
Human   268 SMFNTSHPFYPEFVRSLNMSWRENCEASTYLGPAL--------SAALMFDAVHVVVSAVRELNRS 324

  Fly   316 HSLTLLNISCEEENSWDGGLSLINYLNAVEWKGLTGPIQFKD-GQRVQFKLDLIKLKQHSIVKVG 379
            ..:.:..::|...|.|..|.||:|||..||:.||||.::|.. |||..:.|.:::..:....::|
Human   325 QEIGVKPLACTSANIWPHGTSLMNYLRMVEYDGLTGRVEFNSKGQRTNYTLRILEKSRQGHREIG 389

  Fly   380 EWTPHGHL--NITEPSMFFDAGSMNVTLVVITILETPYVMMHYGKNF---TGNERFYGFCVDILE 439
            .|..:..|  |.|...:.......|.||||.||||.||||..  .||   :|||||.|||||:|.
Human   390 VWYSNRTLAMNATTLDINLSQTLANKTLVVTTILENPYVMRR--PNFQALSGNERFEGFCVDMLR 452

  Fly   440 TISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLM-KYKADLAVGSMTITYARESVIDFTKP 503
            .::..:.|.|.|.||.|..|||.:| .|.|.|||.:|: :.||||||.:.|||..||.||||:||
Human   453 ELAELLRFRYRLRLVEDGLYGAPEP-NGSWTGMVGELINRQKADLAVAAFTITAEREKVIDFSKP 516

  Fly   504 FMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEW----KCIN 564
            ||.||||||::|........|||::|.:..:|:::|:||..||..:::..:|||.||    .|:.
Human   517 FMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLR 581

  Fly   565 ACD--LENISIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTANLA 627
            |..  ||     ||::|.:|.||.:|.||||..:|.|||:|||.:|..|..|:|||::|||||||
Human   582 ARPHILE-----NQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLA 641

  Fly   628 AFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFTTTY 692
            ||||.:||..|:|:|:|||.||.|.|||:.:|||||||::|..:||:::|..|.:|:||.|..:.
Human   642 AFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKST 706

  Fly   693 EDGIKRVNQGNYAFLMESTMLDYIVQRDCNLTQIGGLLDTKGYGIATPKGSPWRDKISLAILELQ 757
            |:||.||....||||:||||.:|..:.:|||||||||||||||||..|.|||:||:|:||||:||
Human   707 EEGIARVLNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQ 771

  Fly   758 ERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFEFWYNF 822
            |...:::|..|||:.  ..|.::   :..:|..||:|:|||:|:|||.|:|:|..||..||.::.
Human   772 ENNRLEILKRKWWEG--GRCPKE---EDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWST 831

  Fly   823 RYNYEA--TPS 831
            |.:.|:  ||:
Human   832 RRSAESEETPA 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	94/383 (25%)
		ANF_receptor	39..371	CDD:279440	87/349 (25%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	200/378 (53%)
		Lig_chan	533..807	CDD:278489	141/279 (51%)
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	25..399	CDD:107389	94/382 (25%)
		ANF_receptor	42..379	CDD:279440	86/345 (25%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:304360	200/378 (53%)
		Lig_chan	546..816	CDD:278489	141/279 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156276
Domainoid	1	1.000	362	1.000	Domainoid score	I955
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.850