DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ekar and GRIK4

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_001269399.1	Gene:	GRIK4 / 2900	HGNCID:	4582	Length:	956	Species:	Homo sapiens

Alignment Length:	916	Identity:	341/916 - (37%)
Similarity:	505/916 - (55%)	Gaps:	98/916 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 PPLVRIGAIFSNQPGMYNSE-LAFRYAIHRLNMDKSLLPETTVDYYVEYVNRFDSFETVQKVCKL 83
            |..:||.||..:.......| |:...|.:|:|.....|.:..|:..:..:.|...:||.:.:|::
Human    22 PHSLRIAAILDDPMECSRGERLSITLAKNRINRAPERLGKAKVEVDIFELLRDSEYETAETMCQI 86

  Fly    84 IRVGVQAVFSPTDSVLATH-INSICDALDIPNIGRSAHDF---------SINVYPSKQLVNYAFN 138
            :..||.||..|:.|..::. |::||...::|:...:..:|         ::|::||...::.|..
Human    87 LPKGVVAVLGPSSSPASSSIISNICGEKEVPHFKVAPEEFVKFQFQRFTTLNLHPSNTDISVAVA 151

  Fly   139 DVIQYLNWTRFGILHEKENGIINLHQLSRSF-----HGEVHMRQVSRDSYVSALNEFKGKEIHNI 198
            .::.:.|.|...::..|...::||.:|.|.|     ...|.|...:||. ...|.|.:..:...|
Human   152 GILNFFNCTTACLICAKAECLLNLEKLLRQFLISKDTLSVRMLDDTRDP-TPLLKEIRDDKTATI 215

  Fly   199 IIDTN-SNGISILLKNILQQQMNEYKYHYLFTSFDLETYDLEDFKYNFVNITSFRLVDTADVGVK 262
            ||..| |...:||||......::.| |.|:||:.:.....::....:.|||..|.:.:.:....:
Human   216 IIHANASMSHTILLKAAELGMVSAY-YTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQ 279

  Fly   263 QILKDIGL-----YSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGLQTLEQSHSLTLLN 322
            :..:.:..     ..|..|..|.|:            .||:||:||.....:|.|.:|..:.:..
Human   280 EFAQSLNQSWQENCDHVPFTGPALS------------SALLFDAVYAVVTAVQELNRSQEIGVKP 332

  Fly   323 ISCEEENSWDGGLSLINYLNAVEWKGLTGPIQFKD-GQRVQFKLDLIKLKQHSIVKVGEW----- 381
            :||.....|..|.||:|||..||.:||||.|:|.. |||..:.|.:::..::...::|:|
Human   333 LSCGSAQIWQHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALKILQFTRNGFRQIGQWHVAEG 397

  Fly   382 -TPHGHL---NITEPSMFFDAGSMNVTLVVITILETPYVMM---HYGKNFTGNERFYGFCVDILE 439
             :...||   ||:: ::|      |.||||.||||.||:|:   |  :...||:|:.|||||:|:
Human   398 LSMDSHLYASNISD-TLF------NTTLVVTTILENPYLMLKGNH--QEMEGNDRYEGFCVDMLK 453

  Fly   440 TISREVGFDYILDLVPDRKYGAKDPE-TGEWNGMVAQLMKYKADLAVGSMTITYARESVIDFTKP 503
            .::..:.|:|.:.||.|..||.  || .|.|.|||.:|:..||||||..:|||..||.||||:||
Human   454 ELAEILRFNYKIRLVGDGVYGV--PEANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKP 516

  Fly   504 FMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEW----KCIN 564
            ||.||||||::|........|||::|.:..:|:::|:||..||..:::|.:|:|.||    .|..
Human   517 FMTLGISILYRVHMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQ 581

  Fly   565 A-CDLENISIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTANLAA 628
            . |:|    :.||:||.:|.||.:|.||||...|.|||:|||.:|..|..|:|||::||||||||
Human   582 GRCNL----LVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAA 642

  Fly   629 FLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYE 693
            |||.:||..|||:.:|||.||.|.|||:..||:||||::|..:||:::|..|.:|:||.|..:.|
Human   643 FLTVQRMDVPIESVDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTE 707

  Fly   694 DGIKRVNQGNYAFLMESTMLDYIVQRDCNLTQIGGLLDTKGYGIATPKGSPWRDKISLAILELQE 758
            :||.||...|||||:||||.:|..||:|||||||||||||||||..|.||.:||:..||||:|||
Human   708 EGIARVLNSNYAFLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQE 772

  Fly   759 RGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFEFWYNFR 823
            ...:::|..|||:.  ..|.::   :..:|..||:|:|||:|||||.|:|||..:|..||.:..|
Human   773 NNRLEILKRKWWEG--GKCPKE---EDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLR 832

  Fly   824 YNYEATP---SQSVVNNKYN----QDGILESERN-YTPPDRSFWIEIAEELRYASWCMNKQKRPA 880
            :: |||.   .|.:|....:    ||.|....|. ..||.|.   .|.||           :||.
Human   833 HS-EATEVSVCQEMVTELRSIILCQDSIHPRRRRAAVPPPRP---PIPEE-----------RRPR 882

  Fly   881 LTRTCS 886
            .|.|.|
Human   883 GTATLS 888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	100/395 (25%)
		ANF_receptor	39..371	CDD:279440	92/354 (26%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	195/377 (52%)
		Lig_chan	533..807	CDD:278489	142/278 (51%)
GRIK4	NP_001269399.1	PBP1_iGluR_Kainate_KA1_2	26..400	CDD:107389	98/387 (25%)
		ANF_receptor	43..382	CDD:279440	91/352 (26%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	195/377 (52%)
		Lig_chan	547..816	CDD:278489	142/277 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	863..889		12/40 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..956
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155783
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.610