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Protein Alignment Ekar and GRIK1

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_001317923.1	Gene:	GRIK1 / 2897	HGNCID:	4579	Length:	949	Species:	Homo sapiens

Alignment Length:	944	Identity:	368/944 - (38%)
Similarity:	555/944 - (58%)	Gaps:	87/944 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SGFLLFQFLSYGL--GVPPLVRIGAIF---SNQPGMYNSELAFRYAIHRLNMDKSLLPETTVDYY 64
            :.:.|..||.|.|  ..|.::|||.||   .|:| :...||||::|:..:|.:::|:|.||:.|.
Human    17 TSWALLYFLCYILPQTAPQVLRIGGIFETVENEP-VNVEELAFKFAVTSINRNRTLMPNTTLTYD 80

  Fly    65 VEYVNRFDSFETVQKVCKLIRVGVQAVFSPTDSVLATHINSICDALDIPNI-GRSAHD------- 121
            ::.:|.|||||..::.|..:.:||.|:|.|:.|...:.:.|||:||::|:| .|..|.
Human    81 IQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNKDL 145

  Fly   122 FSINVYPSKQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQLSRS---FHGEVHMRQV---SR 180
            |.||:||....::.|..|::.|.||....:::|...|:|.|.:|.::   ::.::.:||:   ::
Human   146 FYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLPSGNK 210

  Fly   181 DSYVSALNEFKGKEIHNIIIDTNSNGISILLKNIL-QQQMNEYKYHYLFTSFDLETYDLEDFKYN 244
            |:........||||.: :|.|.:....:.:||.|| ...|.|| |||.||:.||...|||.::|:
Human   211 DAKPLLKEMKKGKEFY-VIFDCSHETAAEILKQILFMGMMTEY-YHYFFTTLDLFALDLELYRYS 273

  Fly   245 FVNITSFRLVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGL 309
            .||:|.|||::..:..|..|::...:.......:|...|   ...::.:|.|||:|:||:.||..
Human   274 GVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGL---LDGMMTTEAALMYDAVYMVAIAS 335

  Fly   310 QTLEQSHSLTLLNISCEEENSWDGGLSLINYLNAVEWKGLTGPIQFK--DGQRVQFKLDLIKLKQ 372
            ....|   ||:.::.|.....|..|...:|.:....|.||||.|.|.  :|.|..|.||:|.||:
Human   336 HRASQ---LTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKE 397

  Fly   373 HSI---------------VKVGEWTPHGHLNITEPSMFFDAGS------MNVTLVVITILETPYV 416
            ...               .|:|.|..:..||:|:.:.  |..|      .|.||:|.||||.|||
Human   398 EGTEKAAGEVSKHLYKVWKKIGIWNSNSGLNMTDSNK--DKSSNITDSLANRTLIVTTILEEPYV 460

  Fly   417 MMHYG-KNFTGNERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYK 480
            |.... |...||:||.|:|:|:|:.:|..:||.|.:.||||.||||:: :.|||||||.:|:.::
Human   461 MYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQN-DKGEWNGMVKELIDHR 524

  Fly   481 ADLAVGSMTITYARESVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLV 545
            |||||..:||||.||.||||:||||.||||||::.|......:|||:|||:.:||:|||:|...|
Human   525 ADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGV 589

  Fly   546 SLCIYIVGKLSPIEWKCINACDLENISIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISST 610
            |..::::.:.:|.||...:.|:.::..:.|.|:|.:||||.:|..|||..::.|:|:||||:...
Human   590 SCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGI 654

  Fly   611 WGFFSLIIVASYTANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRDSVIETYKK 675
            |.||:|||::|||||||||||.|||.:||::|:|||.||:|.||.:..|||||||:.|.|.||:|
Human   655 WWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEK 719

  Fly   676 IWRSMDNKKPSAFTTTYEDGIKRVNQGNYAFLMESTMLDYIVQRDCNLTQIGGLLDTKGYGIATP 740
            :|..|.:::.:|.....::||:||...:||.|||||.::|:.||:|||||||||:|:||||:.||
Human   720 MWAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTP 784

  Fly   741 KGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIA 805
            .|||:||||::|||:|||.|.:.|:.:|||:...  |..::   ..:|::||:|:|||:|:||.|
Human   785 IGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNG--CPEED---NKEASALGVENIGGIFIVLAA 844

  Fly   806 GIIVAAVVAFFEFWYNFRYNYEATPSQSVVNNKYNQDG--------ILESERNYTPPDRSFWIE- 861
            |::::..||..||.|..|           .||...|.|        .....|.:....:|..:|
Human   845 GLVLSVFVAIGEFIYKSR-----------KNNDIEQKGKSSRIRFYFRNKVRFHGRKKQSLGVEK 898

  Fly   862 ------IAEELRYASWCMNKQKRPALTRTCSKCT 889
                  |.|||..:.....|.|:.:.|:..|..|
Human   899 CLSFNAIMEELGISLKNQKKIKKKSRTKGKSSFT 932

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.