DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ekar and GRID1

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_060021.1	Gene:	GRID1 / 2894	HGNCID:	4575	Length:	1009	Species:	Homo sapiens

Alignment Length:	891	Identity:	253/891 - (28%)
Similarity:	433/891 - (48%)	Gaps:	126/891 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LVRIGAIFSNQPGMYNSELAFRYAIHRLNMDKSLLPETTVDYYVEYVNRFDSFETVQKVCKLIRV 86
            ::.|||||.....  ..:..|:.|:..|:::..:|....:.|.::.:...:.|:.||:.|.|:..
Human    23 IIHIGAIFEENAA--KDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEACDLMTQ 85

  Fly    87 GVQAVFSPTDSVLATHINSICDALDIPNI-------GRSAHDFSINVYPSKQLVNYA------FN 138
            |:.|:.:.|....|..:.|:.||:.||::       |.......:|..|..:....|      .|
Human    86 GILALVTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYTLASRPPVRLN 150

  Fly   139 DV----IQYLNWTRFGILHEKENGIINLH----QLSRSFHGEVHMRQVSRD---SYVSALNEFKG 192
            ||    :..|.|.:|.:.::.|..|..|.    |.|| ...:|.:::|.::   .:.|.....|.
Human   151 DVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASR-LGLDVSLQKVDKNISHVFTSLFTTMKT 214

  Fly   193 KEIHNIIIDTNSNGISIL--------LKNILQQQMNEYKYHYLFTSFDLETYDLEDFKYNFV-NI 248
            :|: |...||....|.:|        :...::..:.....|::|.:.::...::.|..::.: .:
Human   215 EEL-NRYRDTLRRAILLLSPQGAHSFINEAVETNLASKDSHWVFVNEEISDPEILDLVHSALGRM 278

  Fly   249 TSFRLVDTADVGVKQILKDIGLYSHHIF------KKPYLNLHIKKSTILESEPALMFDSVYVFAI 307
            |..|.:..:....::..::    :|.|.      ::.||.:       |:.....::|||.:.|.
Human   279 TVVRQIFPSAKDNQKCTRN----NHRISSLLCDPQEGYLQM-------LQISNLYLYDSVLMLAN 332

  Fly   308 GL-QTLEQS--HSLTLLNISCEEENSWDGGLSLINYLNAVEWKGLTGPIQFKDGQR---VQFKL- 365
            .. :.||..  ||:..||...:....|:||.|:::.:......||||.::|::...   |||::
Human   333 AFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIKKGHITGLTGVMEFREDSSNPYVQFEIL 397

  Fly   366 ----------DLIKLKQHSIVKVGEWTPHGHLN--ITEPSMFFDAGS--MNVTLVVITILETPYV 416
                      |:.||        ..|.....||  :.|..|    ||  ..:||.|:|:||.|:|
Human   398 GTTYSETFGKDMRKL--------ATWDSEKGLNGSLQERPM----GSRLQGLTLKVVTVLEEPFV 450

  Fly   417 MMHYGKNFTGN-ERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYK 480
            |:  .:|..|. :|:.||.:|:|:.:::.:||.|.:...||.:||.:...| .||||:.:|:..:
Human   451 MV--AENILGQPKRYKGFSIDVLDALAKALGFKYEIYQAPDGRYGHQLHNT-SWNGMIGELISKR 512

  Fly   481 ADLAVGSMTITYARESVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLV 545
            ||||:.::|||..||||:||:|.:|:..:.||.|.| .|...:||...|....:|..:..|..:|
Human   513 ADLAISAITITPERESVVDFSKRYMDYSVGILIKKP-EEKISIFSLFAPFDFAVWACIAAAIPVV 576

  Fly   546 SLCIYIVGKLSPIEWKCINACDLENISIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISST 610
            .:.|:::.::     :.:.|............:|..:.|...|.|:||..:....:|:.||:..:
Human   577 GVLIFVLNRI-----QAVRAQSAAQPRPSASATLHSAIWIVYGAFVQQGGESSVNSMAMRIVMGS 636

  Fly   611 WGFFSLIIVASYTANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFR--------- 666
            |..|:||:.:|||||||||||..||.|||...:||:.|.|:||||:...:...:||
Human   637 WWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQVEMSYGTVRDSAVYEYFRAKGTNPLEQ 701

  Fly   667 DSVIETYKKIWRSM------DN--KKPSAFTTTYEDGIKRVNQGNYAFLMESTMLDY--IVQRDC 721
            ||   |:.::||::      ||  ..||       :||::..:||||||.:..:::|  :...||
Human   702 DS---TFAELWRTISKNGGADNCVSSPS-------EGIRKAKKGNYAFLWDVAVVEYAALTDDDC 756

  Fly   722 NLTQIGGLLDTKGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQS 786
            ::|.||..:.:||||||...|||:||..|..|||||:.||:.:|..|||.:........:.|.|:
Human   757 SVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQA 821

  Fly   787 KANSLGLESIGGVFVVLIAGIIVAAVVAFFEFWYNFRYNYEATPSQ 832
            ...||.|.|..|||.:|..|:::|.:||..|.|:|....::.||.:
Human   822 DGKSLKLHSFAGVFCILAIGLLLACLVAALELWWNSNRCHQETPKE 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	86/419 (21%)
		ANF_receptor	39..371	CDD:279440	79/387 (20%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	141/388 (36%)
		Lig_chan	533..807	CDD:278489	100/292 (34%)
GRID1	NP_060021.1	Interaction with CBLN1. /evidence=ECO:0000250\|UniProtKB:Q61627	21..436		92/439 (21%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	87/420 (21%)
		ANF_receptor	41..400	CDD:279440	77/371 (21%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	141/388 (36%)
		Lig_chan	564..841	CDD:278489	100/291 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	930..954
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155875
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840